PubMed,
Год журнала:
2024,
Номер
27(2), С. 157 - 164
Опубликована: Янв. 1, 2024
The
primary
gene
mutations
associated
with
nasopharyngeal
carcinoma
(NPC)
are
located
within
the
phosphoinositide
3-kinase-mammalian
target
of
rapamycin
signaling
pathways,
which
have
inhibitory
effects
on
autophagy.
Compounds
that
autophagy
could
potentially
be
used
to
treat
NPC.
However,
autophagy-related
molecular
targets
in
NPC
remain
elucidated.
We
aimed
examine
levels
genes,
including
4B
cysteine
peptidase
(ATG4B)
and
gamma-aminobutyric
acid
(GABA)
type
A
receptor-associated
protein-like
1
(GABARAPL1),
cells
explored
their
potential
role
as
novel
for
treatment
Cancers,
Год журнала:
2023,
Номер
15(9), С. 2544 - 2544
Опубликована: Апрель 28, 2023
Euterpe
oleracea
(açaí)
fruit
has
approximately
15%
pulp,
which
is
partly
edible
and
commercialized,
85%
seeds.
Although
açaí
seeds
are
rich
in
catechins-polyphenolic
compounds
with
antioxidant,
anti-inflammatory,
antitumor
effects-almost
935,000
tons/year
of
discarded
as
industrial
waste.
This
work
evaluated
the
properties
E.
vitro
vivo
a
solid
Ehrlich
tumor
mice.
The
seed
extract
presented
86.26
±
0.189
mg
catechin/g
extract.
palm
pulp
extracts
did
not
exhibit
activity,
while
showed
cytotoxic
effects
on
LNCaP
prostate
cancer
cell
line,
inducing
mitochondrial
nuclear
alterations.
Oral
treatments
were
performed
daily
at
100,
200,
400
mg/kg
development
histology
evaluated,
along
immunological
toxicological
parameters.
Treatment
reduced
size,
pleomorphism,
mitosis
figures,
increasing
necrosis.
Treated
groups
cellularity
lymphoid
organs
comparable
to
untreated
group,
suggesting
less
infiltration
lymph
node
spleen
preservation
bone
marrow.
highest
doses
IL-6
induced
IFN-γ,
immunomodulatory
effects.
Thus,
can
be
an
important
source
immunoprotective
properties.
Saudi Journal of Biological Sciences,
Год журнала:
2023,
Номер
31(1), С. 103896 - 103896
Опубликована: Дек. 10, 2023
Breast
cancer
(BC)
is
the
most
common
type
of
malignancy
globally
and
main
reason
why
women
die
from
tumours.
The
Warburg
effect,
a
characteristic
tumor,
describes
how
solid
tumour
cells
acclimatize
to
their
diverse
surroundings
by
relying
heavily
on
aerobic
glycolysis
for
production
energy.
In
addition
producing
key
metabolic
intermediates
that
are
crucial
macromolecules,
which
enable
cell
division,
invasiveness,
drug
resistance,
transformed
energy
metabolism
also
supplies
tumor
with
ATP
cellular
Here,
we
evaluated
expression
profile,
prognostic
significance,
clinical
relevance
glucose-related
genes
in
BC
using
bioinformatic
approach.
To
clarify
significance
development
breast
tumours,
performed
functional
enrichment
investigation
deregulated
STRING
KEGG
portal.
study
depicted
61
examined,
8
had
fold
change
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Март 23, 2023
Abstract
The
most
recurrent
type
of
cancer
among
women
is
breast
which
an
intricate
disease
with
high
intratumoral
and
heterogeneity.
Such
variability
a
key
factor
in
the
failure
current
treatments
emergence
resistance.
It
crucial
to
develop
novel
therapeutic
options
enhance
prognosis
for
patients
due
limitations
therapy
unavoidable
formation
acquired
drug
resistance
(chemo
endocrine)
as
well
radio
Poor
clinical
results
treatment
that
resistant
are
associated
deregulated
Notch
signalling
within
tumor
its
microenvironment
(TME).
In
this
research,
bioinformatics
approach
was
used
check
expression
pattern,
role,
prognostic
diagnostic
significance
Notch-related
genes
BC
patients.
study
demonstrates
highly
dysregulated
(NOTCH4,
CCND1,
JAG1,
DLL1,
MAML2,
EGFR)
can
be
biomarkers
identify
poor
potential
targets
intervention.
found
6
genes—NOTCH4,
EGFR—out
22
tested
showed
significant
log2
fold
change.
Our
revealed
Luminal
Breast
Cancer
display
CCND1
gene
comparison
normal.
our
also
depicted
elevated
levels
NOTCH-related
displayed
better
relapse-free
survival
p
<
0.05.
Moreover,
we
analysed
these
notch
play
important
role
various
cellular
molecular
processes.
shows
screened
could
utilized
Biomarkers
help
reveal
act
treating
BC.
PubMed,
Год журнала:
2024,
Номер
27(2), С. 157 - 164
Опубликована: Янв. 1, 2024
The
primary
gene
mutations
associated
with
nasopharyngeal
carcinoma
(NPC)
are
located
within
the
phosphoinositide
3-kinase-mammalian
target
of
rapamycin
signaling
pathways,
which
have
inhibitory
effects
on
autophagy.
Compounds
that
autophagy
could
potentially
be
used
to
treat
NPC.
However,
autophagy-related
molecular
targets
in
NPC
remain
elucidated.
We
aimed
examine
levels
genes,
including
4B
cysteine
peptidase
(ATG4B)
and
gamma-aminobutyric
acid
(GABA)
type
A
receptor-associated
protein-like
1
(GABARAPL1),
cells
explored
their
potential
role
as
novel
for
treatment
