Causal link between dietary antioxidant vitamins intake, oxidative stress injury biomarkers and colorectal cancer: A Mendelian randomization study

Medicine, Год журнала: 2025, Номер 104(7), С. e41531 - e41531

Опубликована: Фев. 14, 2025

Oxidative stress and reactive oxygen species play a pivotal role in carcinogenesis. Recent studies have indicated potential reduction cancer incidence associated with antioxidant intake; however, these results remain controversial. We performed 2-sample Mendelian randomization (MR) analysis to explore the causal relationship between dietary vitamins (retinol, carotene, vitamin C, E), oxidative injury biomarkers (GST, CAT, SOD, GPX), risk of colorectal (CRC). The genetic instrumental variants (IVs) that had previously shown significant association were screened from UK Biobank relevant published studies. genome-wide study (GWAS) data for total colorectal, colon, rectal obtained FinnGen cohort. primary MR employed inverse-variance-weighted (IVW) method. Furthermore, sensitivity was assess heterogeneity horizontal pleiotropy. revealed no associations vitamins, biomarkers, CRC. odds ratios (ORs) as follows: 1.22 (95% confidence interval (CI): 0.65–2.28, P = .53) retinol, 0.77 CI: 0.50–1.18, .24) 0.82 0.42–1.63, .58) 1.20 0.86–1.68, .28) E. Regarding ORs 0.99 0.93–1.06, .88) GST, 0.93–1.05, .65) 1.02 0.95–1.09, .57) 1.01 0.95–1.07, .76) GPX. Likewise, stratified by tumor site beneficial effects colon cancers. Our findings indicate elevated levels diet-related well injury, do not provide protective effect against CRC risk.

Язык: Английский

High-dose Vitamin C inhibits PD-L1 expression by activating AMPK in colorectal cancer

Immunobiology, Год журнала: 2025, Номер unknown, С. 152893 - 152893

Опубликована: Март 1, 2025

Язык: Английский