Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106568 - 106568
Опубликована: Дек. 1, 2024
Язык: Английский
Results in Chemistry, Год журнала: 2024, Номер 8, С. 101559 - 101559
Опубликована: Май 24, 2024
This comprehensive review examines the diverse range of uses gold nanoparticles across numerous disciplines, focusing on their distinctive characteristics in catalysis, thermal conductivity, optical properties, electrical and biological interactions. work emphasizes crucial significance progression cancer treatment, demonstrating multifunctionality areas drug transport, photothermal therapy, bioimaging, diagnostic applications. Gold have demonstrated utility improving accuracy effectiveness treatments, presenting innovative approaches to address clinical obstacles. Nevertheless, research also discusses notable challenges, including apprehensions over toxicity, influence nanoparticle size, potential environmental repercussions. These issues emphasize necessity responsible administration fully exploit capabilities context therapy. Notwithstanding these obstacles, ultimately underscores profound domains such as monitoring, renewable energy, healthcare, cosmetics, biotechnology. highlights capacity mold future through inventive adaptable means
Язык: Английский
Процитировано
14
Frontiers in Oncology, Год журнала: 2025, Номер 14
Опубликована: Янв. 8, 2025
Photodynamic diagnosis (PDD) and autofluorescence imaging (AFI) are emerging cancer diagnostic technologies that offer significant advantages over traditional white-light endoscopy in detecting precancerous lesions early-stage cancers; moreover, they hold promising potential fluorescence-guided surgery (FGS) for tumors. However, their shortcomings have somewhat hindered the clinical application of PDD AFI. Therefore, it is imperative to enhance efficacy AFI, thereby maximizing practical use. This article reviews principles, characteristics, current research status, advancements focusing on analyzing discussing optimization strategies AFI tumor FGS scenarios. Considering technical feasibility, optimizing may result an effective real-time tool guide clinicians surgical guidance achieve best results.
Язык: Английский
Процитировано
0
Medicina, Год журнала: 2025, Номер 61(2), С. 326 - 326
Опубликована: Фев. 13, 2025
Cervical cancer and its precursors (cervical intraepithelial neoplasia (CIN)) represent a current major public health concern. Currently, the treatment of choice for patients with HSILs (high-grade lesions) is surgical treatment-LEEP or cold-knife conization-except in pregnant women, where it may have significant future consequences. In this paper, we aim to review evidence regarding efficacy non-surgical approaches CINs. Therefore, searched Google Scholar PubMed papers on CIN treatments; 91 studies published English were included analysis. The results reviewed variable depending agent methodology used. Overall, remission rates II ranged from 43 93%. However, some agents, contradictory. Once topical agents been proven be effective, they could used as an alternative methods treating HPV-associated CIN, fewer adverse effects. use local allow more personalized treatments Future directions also sought.
Язык: Английский
Процитировано
0
Hereditas, Год журнала: 2025, Номер 162(1)
Опубликована: Март 29, 2025
Cervical cancer (CC), a prevalent gynecological malignancy, shows high global incidence and mortality. Tripartite motif-containing 37 (TRIM37), significant ubiquitinating enzyme, is overexpressed in CC, fueling its progression, but role ferroptosis here unknown. TRIM37 expression CC tissues was first predicted using bioinformatics software. Then, RT-qPCR Western blot were utilized to confirm cells. Subsequently, cellular behaviors examined by EdU, flow cytometry, Transwell assay. Besides, ferroptosis-related indicators detected corresponding kits. The dual luciferase reporter assay conducted identify the binding between Activating Transcription Factor 6 (ATF6). Additionally, Co-IP applied validate interaction Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4). Finally, functions of vivo investigated establishing xenograft tumor model. increased Silencing suppressed cell malignant promoted ferroptosis. ATF6 activated transcription, with upregulation counteracting knockdown effects. degraded ACSL4, silencing ACSL4 reversed overexpression counteracted knockdown's impact on growth vivo. regulated TRIM37, which turn ubiquitination degradation facilitating progression CC.
Язык: Английский
Процитировано
0
Current Topics in Medicinal Chemistry, Год журнала: 2024, Номер 24(12), С. 1050 - 1074
Опубликована: Янв. 26, 2024
Annually, a significant number of individuals succumb to cancer, an anomalous cellular condition characterized by uncontrolled proliferation and the emergence highly perilous tumors. Identifying underlying molecular mechanism(s) driving disease progression has led various inventive therapeutic approaches, many which are presently under pre-clinical and/or clinical trials. Over recent years, numerous alternative strategies for addressing cancer have also been proposed put into practice. This article delineates modern drugs employed in treatment their associated toxicity. Due inherent drug toxicity with most treatments, demand rises therapies phytochemicals minimal side effects proven efficacy against cancer. Analogs taxol,
Язык: Английский
Процитировано
3
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Год журнала: 2024, Номер 32(3), С. 433 - 437
Опубликована: Янв. 1, 2024
The main aim of antineoplastic treatment is to maximize patient benefit by augmenting the drug accumulation within affected organs and tissues, thus incrementing effects and, at same time, reducing damage non-involved tissues cytotoxic agents. Mesenchymal stromal cells (MSC) represent a group undifferentiated multipotent presenting wide self-renewal features capacity differentiate into an assortment mesenchymal family cells. During last year, they have been proposed as natural carriers for selective release antitumor drugs malignant cells, optimizing action on cancer while significantly adverse side healthy MSC chemotherapeutic loading delivery encouraging new area cell therapy several tumors, especially those with unsatisfactory prognosis limited options available. Although some experimental models successfully developed, phase I clinical studies are needed confirm this potential application therapy, in particular case primary secondary lung cancers.
Язык: Английский
Процитировано
2
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Сен. 13, 2024
Cervical cancer is one of the most malignant gynaecological tumors characterised with aggressive behaviour tumor cells. In spite development different strategies for treatment cervical cancer, cells have developed resistance to conventional therapeutics. On other hand, nanoparticles been recently applied human cancers through delivery drugs and facilitate suppression. The stimuli-sensitive nanostructures can improve release therapeutics at site. present review, are discussed. Nanostructures deliver both chemotherapy natural compounds increase anti-cancer activity prevent drug in tumor. Moreover, genetic tools such as siRNA be delivered by enhance their accumulation order selectivity, stimuli-responsive pH- redox-responsive nanocarriers suppress induce photo-thermal photodynamic therapy accelerate cell death addition, nanobiotechnology demonstrates tremendous potential especially context immunotherapy. Overall, metal-, carbon-, lipid- polymer-based utilized therapy. Finally, hydrogels novel kinds carriers encapsulate activity.
Язык: Английский
Процитировано
2
Talanta Open, Год журнала: 2023, Номер 9, С. 100276 - 100276
Опубликована: Дек. 7, 2023
Biomimetic sensors are devices that replicate biological receptors and enzymes with extraordinary accuracy sensitivity by taking their cues from nature's effective mechanisms. They enable quick diagnosis better treatment options providing non-invasive detection of cancer-specific biomarkers in physiological fluids. This review addresses numerous optical electronic biomimetic sensor types emphasizes the benefits usage cancer diagnostics. Some recognition components used aptamers, molecularly imprinted polymers (MIPs), immunomimetic sensors. The widespread use for diagnostics has promise despite obstacles like specificity cost-effectiveness. wearable technology artificial intelligence improves individualized management even further. overall objective this is to comprehensively explore field biomimetics context diagnostics, highlighting various emphasize on significant sensors, such as sensitivity, enabling biomarkers. Overall, a revolutionary development advances our understanding early detection, improved patient outcomes, enhanced healthcare.
Язык: Английский
Процитировано
4
JOURNAL OF SURGICAL AND CLINICAL RESEARCH, Год журнала: 2024, Номер 15(1), С. 59 - 78
Опубликована: Июль 8, 2024
The integration of nanotechnology and immune therapy presents a revolutionary approach to cancer treatment, merging the precision nanoscale engineering with power system combat malignancies. This review article explores synergy between therapy, highlighting its potential enhance antineoplastic efficiency mitigate hepatotoxicity, particular focus on liver treatments. Nanotechnology offers novel solutions for targeted drug delivery, controlled release, co-delivery therapeutic agents, thus improving bioavailability efficacy therapies. By overcoming challenges posed by immunosuppressive tumor microenvironment (TME), nanotechnology-enabled strategies can potentiate antitumor response transform "cold" tumors into "hot" ones, making them more amenable immune-mediated destruction. Despite promising advancements, field faces such as optimizing nanoparticle formulations maximal safety, identifying suitable targeting ligands specific types, addressing heterogeneity TME. Comprehensive preclinical clinical studies are required assess biodistribution, metabolism, toxicity nanocarriers. underscores transformative combining offering insights future directions effective, targeted, safer
Язык: Английский
Процитировано
1
Advances in Natural Sciences Nanoscience and Nanotechnology, Год журнала: 2024, Номер 15(4), С. 043001 - 043001
Опубликована: Сен. 18, 2024
Abstract The global outbreak of infectious diseases in recent decades has caused serious health problems worldwide. Key factors that contribute to the lack a complete therapeutic strategy against viral infections include biomimetic architecture, ability manipulate antibody, continuous antigen transfer, covert system injecting inappropriate doses drugs at target sites, resulting drug resistance. Reasons low water solubility, poor permeability, plasma protein high self-similarity, short gene half-life, and rapid elimination. To combat these challenges, nanoparticle-based delivery emerged as revolutionary approach, applying nanoengineering tools nanoparticle synthesis achieve optimal concentrations targeted sites over time nanoparticles with nano dimensional structure enhanced permeability retention effects, increasing surface area volume ratios, surface-functioning capacity, prove effective antiviral but size, shape, charge, topology allow specific delivery, cellular uptake, opsonization by host immune cells, time, transcytosis, extended biological half -life, vivo stability, significantly affect cytotoxicity. This review provides an in-depth analysis critical role nanotechnology-based while addressing important aspects clinical safety efficacy.
Язык: Английский
Процитировано
1