Asian Oncology Nursing, Год журнала: 2024, Номер 24(4), С. 184 - 184
Опубликована: Янв. 1, 2024
Язык: Английский
Journal of the American Medical Informatics Association, Год журнала: 2024, Номер unknown
Опубликована: Июнь 10, 2024
Abstract Objectives Precise literature recommendation and summarization are crucial for biomedical professionals. While the latest iteration of generative pretrained transformer (GPT) incorporates 2 distinct modes—real-time search model utilization—it encounters challenges in dealing with these tasks. Specifically, real-time can pinpoint some relevant articles but occasionally provides fabricated papers, whereas excels generating well-structured summaries struggles to cite specific sources. In response, this study introduces RefAI, an innovative retrieval-augmented tool designed synergize strengths large language models (LLMs) while overcoming their limitations. Materials Methods RefAI utilized PubMed systematic retrieval, employed a novel multivariable algorithm article recommendation, leveraged GPT-4 turbo summarization. Ten queries under prevalent topics (“cancer immunotherapy target therapy” “LLMs medicine”) were chosen as use cases 3 established counterparts (ChatGPT-4, ScholarAI, Gemini) our baselines. The evaluation was conducted by 10 domain experts through standard statistical analyses performance comparison. Results overall surpassed that baselines across 5 evaluated dimensions—relevance quality accuracy, comprehensiveness, reference integration summarization, majority exhibiting statistically significant improvements (P-values <.05). Discussion demonstrated substantial over existing tools, addressing issues like metadata inaccuracies, restricted recommendations, poor integration. Conclusion By augmenting LLM external resources ranking algorithm, is uniquely capable recommending high-quality summaries, holding potential meet critical needs professionals navigating synthesizing vast amounts scientific literature.
Язык: Английский
Процитировано
10
Cells, Год журнала: 2024, Номер 13(22), С. 1924 - 1924
Опубликована: Ноя. 20, 2024
Identifying definitive biomarkers that predict clinical response and resistance to immunotherapy remains a critical challenge. One emerging factor is extracellular acidosis in the tumor microenvironment (TME), which significantly impairs immune cell function contributes failure. However, acidic conditions TME disrupt interaction between cancer cells, driving tumor-infiltrating T cells NK into an inactivated, anergic state. Simultaneously, promotes recruitment activation of immunosuppressive such as myeloid-derived suppressor regulatory (Tregs). Notably, acidity enhances exosome release from Tregs, further amplifying immunosuppression. Tumor thus acts "protective shield," neutralizing anti-tumor responses transforming pro-tumor allies. Therefore, targeting lactate metabolism has emerged promising strategy overcome this barrier, with approaches including buffer agents neutralize pH inhibitors block production or transport, thereby restoring efficacy TME. Recent discoveries have identified genes involved (pHe) regulation, presenting new therapeutic targets. Moreover, ongoing research aims elucidate molecular mechanisms acidification develop treatments modulate levels enhance outcomes. Additionally, future studies are crucial validate safety pHe-targeted therapies patients. Thus, review explores regulation pHe its potential role improving immunotherapy.
Язык: Английский
Процитировано
8
World Journal of Biology Pharmacy and Health Sciences, Год журнала: 2024, Номер 17(2), С. 068 - 079
Опубликована: Фев. 9, 2024
This review provides a comprehensive analysis of the progress made in cancer research within United States. Over past few decades, significant strides have been taken to understand complexities cancer, leading breakthroughs diagnostics, treatment modalities, and overall patient care. The explores key themes, including advancements genomic medicine, immunotherapy, personalized approaches. Advancements medicine emerged as cornerstone research, allowing for deeper understanding genetic basis various cancers. integration precision techniques has facilitated identification specific mutations, paving way targeted therapies tailored individual patients. Genomic profiling not only enhanced diagnostic accuracy but also provided valuable insights into heterogeneity, guiding researchers toward more effective strategies. Immunotherapy revolutionized by harnessing body's immune system target eliminate cells. delves remarkable developing checkpoint inhibitors, adoptive cell therapies, vaccines. These innovations shown unprecedented success treating previously challenging malignancies, offering new hope patients with advanced-stage concept is further explored, emphasizing shift from one-size-fits-all approach tailoring treatments based on characteristics. advent liquid biopsies advanced imaging enabled real-time monitoring responses, facilitating timely adjustments improving outcomes. Despite these advancements, acknowledges persistent challenges, such need collaboration between institutions, imperative increased funding, importance addressing healthcare disparities ongoing commitment interdisciplinary translational initiatives, patient-centered emphasized essential overcoming challenges propelling field USA. In conclusion, this paints picture insights, immunotherapeutic breakthroughs, approaches underscores promising future patients, while acknowledging necessity continued efforts address existing propel even greater advancements.
Язык: Английский
Процитировано
5
Cancer Drug Resistance, Год журнала: 2024, Номер unknown
Опубликована: Сен. 25, 2024
Competing endogenous RNAs (ceRNAs) are transcripts that possess highly similar microRNA response elements (MREs). microRNAs (miRNAs) short, endogenous, single-stranded non-coding (ncRNAs) can repress gene expression by binding to MREs on the 3’ untranslated regions (UTRs) of target mRNA suppress promoting degradation and/or inhibiting protein translation. transcripts, circular (circRNAs), long (lncRNAs), and transcribed pseudogenes could share MREs, they compete for same pool miRNAs. These ceRNAs may affect level one another competing their shared This interplay between different constitutes a ceRNA network, which regulates many important biological processes. Cancer drug resistance is major factor leading treatment failure in patients receiving chemotherapy. It be acquired through genetic, epigenetic, various tumor microenvironment mechanisms. The involvement crosstalk its disruption chemotherapy attracting attention cancer research community. review presents an updated summary latest dysregulation causing across types chemotherapeutic classes. Interestingly, accumulating evidence suggests used as prognostic biomarkers predict clinical Nevertheless, detailed experimental investigations putative networks generated computational algorithms needed support translation therapeutic applications.
Язык: Английский
Процитировано
4
European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 286, С. 117268 - 117268
Опубликована: Янв. 13, 2025
Язык: Английский
Процитировано
0
Journal of medical & health sciences review., Год журнала: 2025, Номер 2(1)
Опубликована: Янв. 15, 2025
Background: Personalized medicine has revolutionized cancer treatment by tailoring therapies to individual genetic and molecular profiles, enabling more targeted effective interventions. Advances in genomic technologies, such as Next-Generation Sequencing (NGS), biomarker analyses have allowed for precise identification of actionable mutations personalized strategies. However, understanding the clinical economic implications these approaches remains a priority optimize their application care. Objective: This study aims evaluate impact on outcomes, focusing progression-free survival (PFS), overall (OS), quality life, cost-effectiveness. By comparing patients receiving treatments with those undergoing standard care, seeks assess benefits challenges associated precision oncology. Methods: A retrospective cohort was conducted at tertiary centers, including diagnosed breast, lung, pancreatic who underwent Genomic profiling performed using NGS (e.g., PD-L1, EGFR, BRCA mutations). Outcomes PFS OS were analyzed Kaplan-Meier analysis Cox proportional hazards models. Cost-effectiveness evaluated through incremental cost-effectiveness ratio (ICER) calculations. Data sources included electronic health records (EHRs), registries, databases The Cancer Genome Atlas (TCGA). Results: Patients interventions demonstrated significantly improved compared (PFS: median 12.4 vs. 8.3 months; OS: 24.6 18.7 months, p < 0.05). Biomarker-driven exhibited highest efficacy, particularly among EGFR BRCA. revealed that medicine, while initially expensive, resulted better quality-adjusted life years (QALYs), making it economically viable long term. Conclusion: findings underscore transformative potential enhancing notable improvements life. high costs accessibility must be addressed ensure broader adoption. Future research should focus scaling exploring utility across diverse populations types.
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 205 - 205
Опубликована: Фев. 6, 2025
Cancer represents a significant societal, public health, and economic challenge. Conventional chemotherapy is based on systemic administration; however, it has current limitations, including poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, the development of multiple drug resistance. These factors underscore need for innovative strategies to enhance delivery directly tumours. However, local treatment also presents challenges, penetration through endothelial layers, tissue density in tumour microenvironment, interstitial fluid pressure, physiological conditions within tumour, permanence at site action. Nanotechnology promising alternative addressing these challenges. This narrative review elucidates potential nanostructured formulations cancer treatment, providing illustrative examples an analysis advantages challenges associated with this approach. Among nanoformulations developed breast, bladder, colorectal, oral, melanoma cancer, polymeric nanoparticles, liposomes, lipid nanohydrogels have demonstrated particular efficacy. systems permit mucoadhesion enhanced penetration, thereby increasing concentration (bioavailability) consequently improving anti-tumour efficacy potentially reducing effects. In addition studies indicating chemotherapy, nanocarriers can be used as theranostic approach combination irradiation methods.
Язык: Английский
Процитировано
0
Bioorganic & Medicinal Chemistry Letters, Год журнала: 2025, Номер 120, С. 130132 - 130132
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
0
Extracellular Vesicles and Circulating Nucleic Acids, Год журнала: 2025, Номер 6(1), С. 112 - 27
Опубликована: Фев. 24, 2025
The role of extracellular vesicles (EVs) in mediating chemoresistance has gained significant attention due to their ability transfer bioactive molecules between drug-resistant and drug-sensitive cells. In particular, they have been demonstrated play an active part breast cancer by the horizontal genetic protein material. This review highlights EVs, particularly miRNA cargo, driving drug resistance cancer. EVs derived from chemoresistant cells carry miRNAs lncRNAs, which are known modulate gene networks involved cell proliferation survival. These cargo suppress apoptosis targeting pro-apoptotic genes like PTEN BIM, promote epithelial-mesenchymal transition (EMT) through regulation pathways such as TGF-β Wnt/b-catenin, contribute tumor growth enhancing angiogenesis modulating microenvironment. Beyond RNA-mediated effects, also functional proteins, including P-glycoprotein Hsp70, impact cellular metabolism survival pathways. Our findings underscore significance chemoresistance, suggesting potential involvement possible prognostic factors predict therapy response therapeutic targets combination with usual therapy.
Язык: Английский
Процитировано
0
Biomaterials Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
The prepared magnetic nanoparticles wrapped in bacterial membranes can promote immunogenic cell death and recruit immune cells to kill tumors.
Язык: Английский
Процитировано
0