FLT3 -mutated AML: Immune Evasion Through Exosome-Mediated Mechanisms and innovative combination therapies targeting Immune escape
Expert Review of Anticancer Therapy,
Год журнала:
2025,
Номер
25(2), С. 143 - 150
Опубликована: Янв. 31, 2025
Acute
Myeloid
Leukemia
is
a
heterogeneous
hematological
malignancy
characterized
by
the
uncontrolled
proliferation
of
abnormal
myeloid
cells.
Besides
several
other
genetic
abnormalities
developed
in
AML,
FLT3
mutations
are
significant
due
to
their
worse
prognostic
impacts
and
therapeutic
resistance.
As
result,
these
enable
AML
cells
develop
mechanisms
for
evading
immune
surveillance.
This
review
discusses
ways
escape
FLT3-mutated
A
literature
search
was
conducted
on
PubMed,
Scopus,
Web
Science
databases,
covering
articles
published
between
2010
2024
with
related
keywords.
The
discussion
covers
cells'
downregulation
recognition
markers,
expression
checkpoint
proteins,
establishment
an
immunosuppressive
tumor
microenvironment.
Specific
attention
given
small
extracellular
vesicles
participation
escape.
focus
exosome-mediated
pathways
possible
combination
therapies.
represent
formidable
challenge
crucial
role
evasion.
Exosomes
major
players
processes.
Combination
therapies
targeting
exosome
pathway
could
significantly
improve
patients'
overall
outcomes.
Understanding
underlying
mechanisms,
including
targeted
therapies,
will
be
required
transcend
existing
limitations
push
newer
strategies
treatment.
Язык: Английский
Role of MicroRNAs in Acute Myeloid Leukemia
Genes,
Год журнала:
2025,
Номер
16(4), С. 446 - 446
Опубликована: Апрель 11, 2025
MicroRNA
(miRNA),
a
significant
class
of
regulatory
non-coding
RNA
(ncRNA),
can
regulate
the
expression
numerous
protein-coding
messenger
RNAs
(mRNAs).
miRNA
plays
an
important
part
in
shaping
human
transcriptome.
So
far,
genome,
about
2500
miRNAs
have
been
found.
Acute
myeloid
leukemia
(AML)
belongs
to
malignant
clonal
disorder
hematopoietic
stem
cells
and
is
characterized
by
uncontrolled
proliferation
abnormal
progenitor
bone
marrow
blood.
For
past
several
years,
scientific
attention
has
attracted
role
AML,
since
alterations
levels
may
contribute
AML
development.
This
review
describes
main
functions
classes
presents
biogenesis.
study
aims
recent
reports
altered
microRNA
their
influence
on
cell
survival,
cycle,
apoptotic
potential.
Additionally,
it
summarizes
correlations
between
target
mRNAs
outlines
particular
subtypes
according
ELN
recommendations.
Язык: Английский
Molecular mechanisms and clinical significance of perineural invasion in malignancies: the pivotal role of tumor-associated Schwann cells in cancer progression and metastasis
Noura A. A. Ebrahim,
Soliman M. A. Soliman,
Maha Othman
и другие.
Medical Oncology,
Год журнала:
2025,
Номер
42(5)
Опубликована: Апрель 21, 2025
Язык: Английский
Anticancer effects of Artemisia campestris extract on acute myeloid leukemia cells: an ex vivo study
Rachid Kharrat,
Fatma Ben Lakhal,
Hiba Souia
и другие.
Medical Oncology,
Год журнала:
2024,
Номер
41(8)
Опубликована: Июль 22, 2024
Язык: Английский
Potential Use of Exosomal Non-Coding MicroRNAs in Leukemia Therapy: A Systematic Review
Cancers,
Год журнала:
2024,
Номер
16(23), С. 3948 - 3948
Опубликована: Ноя. 25, 2024
Leukemia
is
a
heterogeneous
group
of
hematological
malignancies.
Despite
the
enormous
progress
that
has
been
made
in
field
hemato-oncology
recent
years,
there
are
still
many
problems
related
to,
among
others,
disease
recurrence
and
drug
resistance,
which
why
search
for
ideal
biomarkers
with
high
clinical
utility
continues.
Research
shows
exosomes
play
critical
role
biology
leukemia
associated
metastasis,
immune
status
leukemias.
Exosomes
their
cargo
non-coding
RNAs
act
as
kind
intermediary
intercellular
communication
and,
at
same
time,
have
ability
to
manipulate
cell
microenvironment
influence
reaction,
proliferative,
angiogenic,
migratory
properties
cells.
Exosomal
ncRNAs
(in
particular,
circRNAs
microRNAs)
appear
be
promising
cell-free
diagnostic,
prognostic,
treatment
monitoring
This
review
examines
expression
exosomal
leukemias
potential
regulatory
therapy
but
also
conditions
such
relapse,
status.
Given
key
regulating
gene
networks
intracellular
pathways
through
interact
DNA,
transcripts,
proteins
identifying
specific
target
genes,
defining
functions
therapeutic
strategies
will
provide
valuable
information.
Язык: Английский