Sustainable pH-responsive Casein/Hyaluronic Acid Layered Nanoparticles for Targeted Delivery of Metformin to Colorectal Cancer.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106710 - 106710

Опубликована: Фев. 1, 2025

Язык: Английский

Liposomal Ficus carica latex and ficin effects on human colon cancer cell line

Journal of the Science of Food and Agriculture, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Abstract BACKGROUND Challenges such as metabolic instability, short half‐life, poor absorption, and low bioavailability are faced by natural drug candidates, particularly in complex plant‐derived extracts like fig latex, which contains multiple bioactive compounds that complicate standardization encapsulation. This research was conducted to investigate the impact of liposome encapsulation on HT‐29 human colon cancer cell line, using commercially sourced ficin latex samples from Sari Lop Aydin Black cultivars. Ficin latices were encapsulated through thin‐film hydration, their characteristic properties analyzed. The cytotoxic apoptotic effects prepared liposomes also examined cells. RESULTS polydispersity indices zeta potentials consistent with those reported literature, although sizes larger than desired range. Encapsulation efficiency percentage (EE%) values relatively low, ranging 15.5% 23.0%, indicating a significant portion remained unencapsulated. lower EE% may have contributed observed reduction cytotoxicity formulations. Unencapsulated showed dose‐dependent ( P < 0.05), while significantly suppressed toxicity, likely due limited immediate controlled release. Apoptosis results, normalized data, dose‐dependency 0.05) especially for latex. differences apoptosis between 35 mg L −1 unencapsulated treatments at 24 48 h = 0.000 0.012, respectively) further suggest liposomal modulates both induction, potentially reducing off‐target maintaining bioactivity. CONCLUSION It has been determined suppresses pro‐apoptotic latices. © 2025 Author(s). Journal Science Food Agriculture published John Wiley & Sons Ltd behalf Society Chemical Industry.

Язык: Английский

Association Between Hypoglycemia Agents and Long-term Survival Outcomes for Patients with Non–muscle-invasive Bladder Cancer Treated with Intravesical Bacillus Calmette-Guérin Immunotherapy

European Urology Oncology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский