Utilizing NCP@PO(OH)2 as a Core-Shell Magnetic Nano-Catalyst for the Conversion of β-Hydroxy Nitrile to α,β-Unsaturated Carboxylic Acid DOI
Farzaneh Ebrahimzadeh

Letters in Organic Chemistry, Год журнала: 2024, Номер 22(1), С. 70 - 77

Опубликована: Май 30, 2024

The synthesis of &#945;,&#946;-unsaturated compounds is crucial in organic chemistry, especially drug discovery and pharmaceutical development. In this study, NCP@POCl<sub>2</sub>-x (Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@ chitosan@POCl<sub>2</sub>-x) has been introduced as a new, environmentally friendly, highly efficient heterogeneous magnetic nanocatalyst for the carboxylic acids. This catalyst facilitates <i>in situ</i> transformation POCl<sub>2</sub>-x to PO(OH)<sub>2</sub> presence water, effectively converting &#946;-hydroxy nitriles into acids through specific mechanism involving water heat. reactions display notable regioselectivity, leading high-purity products quantitative yields. NCP@PO(OH)<sub>2</sub> exhibits heterogeneity, properties, straightforward recovery, outstanding performance, making it valuable selective transformations nitriles. Additionally, can be easily separated from mixture using external forces.

Язык: Английский

Utilizing NCP@PO(OH)2 as a Core-Shell Magnetic Nano-Catalyst for the Conversion of β-Hydroxy Nitrile to α,β-Unsaturated Carboxylic Acid DOI
Farzaneh Ebrahimzadeh

Letters in Organic Chemistry, Год журнала: 2024, Номер 22(1), С. 70 - 77

Опубликована: Май 30, 2024

The synthesis of &#945;,&#946;-unsaturated compounds is crucial in organic chemistry, especially drug discovery and pharmaceutical development. In this study, NCP@POCl<sub>2</sub>-x (Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@ chitosan@POCl<sub>2</sub>-x) has been introduced as a new, environmentally friendly, highly efficient heterogeneous magnetic nanocatalyst for the carboxylic acids. This catalyst facilitates <i>in situ</i> transformation POCl<sub>2</sub>-x to PO(OH)<sub>2</sub> presence water, effectively converting &#946;-hydroxy nitriles into acids through specific mechanism involving water heat. reactions display notable regioselectivity, leading high-purity products quantitative yields. NCP@PO(OH)<sub>2</sub> exhibits heterogeneity, properties, straightforward recovery, outstanding performance, making it valuable selective transformations nitriles. Additionally, can be easily separated from mixture using external forces.

Язык: Английский

Процитировано

0