HER2-positive gastric cancer: from targeted therapy to CAR-T cell therapy

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 13, 2025

Gastric cancer (GC) ranks as the fifth most prevalent on a global scale, with HER2-positive GC representing distinct subtype that exhibits more intricate biological characteristics. Conventional chemotherapy typically restricted efficacy in management of GC. In light incessant advancement molecular targeted therapies, targeting HER2 has emerged promising therapeutic approach for this subtype. The advent antibody-drug conjugates (ADCs) and chimeric antigen receptor T-cell therapy (CAR-T) furnished novel treatment alternatives Nevertheless, owing to pronounced heterogeneity complex tumor microenvironment, drug resistance frequently emerges, thereby substantially influencing effectiveness HER2-targeted therapy. This article comprehensively summarizes deliberates upon strategies well underlying mechanisms.

Язык: Английский

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Lipid-based Nanoparticles: Strategy for Targeted Cancer Therapy

BIO Integration, Год журнала: 2025, Номер 6(1)

Опубликована: Янв. 1, 2025

Lipid-based Nanoparticles (LBNPs) have emerged as a transformative approach in cancer treatment, offering innovative drug delivery solutions that enhance therapeutic efficacy while minimizing adverse effects. By exploring the characterization, classification, synthesis, targeting strategies, and advantages of LBNPs, this study highlights how LBNPs been used to overcome limitations traditional chemotherapy improve patient outcomes. As nanotechnology revolutionizes therapy, emergence promising strategy for targeted has led optimism regarding future treatment. This review extensively assesses structure, categories, production methods, benefits, recent advancements treating cancer. It also current challenges possible directions. is aimed at providing comprehensive understanding LBNPs’ potential therapy. Liposomes, nanostructured lipid carriers, solid nanoparticles, lipid-polymer hybrid nanoparticles are all types each with unique features interest These particles can be synthesized through various procedures, such bulk nanoprecipitation, solvent-based emulsification, or microfluidics. Passive systems, active responsive platforms direct tumors. Consequently, provide an improved release pattern minimizes side effects enhancing efficacy. With combination offer hopeful Continued research expected outcomes overall quality life care.

Язык: Английский

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Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application

FEBS Journal, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Multiple myeloma (MM), characterised by the clonal proliferation of plasma cells in bone marrow, is second most common haematological malignancy worldwide. Although there now an impressive artillery therapeutics to tackle this condition, resistance remains a prevalent issue. The marrow microenvironment performs crucial role supporting MM pathogenesis and promoting development therapeutic resistance. Extracellular vesicles (EVs), small that carry bioactive molecules, are key component cell‐to‐cell communication within microenvironment. In review, we summarise contribution EVs disease progression anticancer treatment discuss potential applications MM.

Язык: Английский

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Molecular mechanisms and clinical significance of perineural invasion in malignancies: the pivotal role of tumor-associated Schwann cells in cancer progression and metastasis

Medical Oncology, Год журнала: 2025, Номер 42(5)

Опубликована: Апрель 21, 2025

Язык: Английский

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