Multifunctional nanoplatform for tumor chemodynamic and Self-Amplified photodynamic Cascade therapy DOI Creative Commons
Xiaoling Luo, Haifeng Qi, M. Yan

и другие.

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

5-Aminolevulinic acid (5-ALA)-based photodynamic therapy (PDT) has demonstrated considerable potential in breast cancer treatment. However, its efficacy is limited by low tissue selectivity and the rapid conversion of 5-ALA to non-photosensitive heme tumor tissues, reducing therapeutic effectiveness. This study aims develop a multifunctional nanomedicine enhance 5-ALA's PDT while introducing chemodynamic (CDT) for synergistic inhibition. By designing zinc-ion-doped cuprous metal-organic framework (MOF) nanocarrier loaded with (5-ALA@Zn-CuTz), we seek improve targeting, prolong photosensitizer retention, outcomes. To biocompatibility active surface 5-ALA@Zn-CuTz nanoparticles (NPs) was modified platelet membrane (PM), forming 5-ALA@Zn-CuTz@PM NPs. The evaluated vitro vivo using mice models. Cellular uptake, reactive oxygen species (ROS) generation, inhibition efficiency were analyzed through fluorescence imaging, biochemical assays, histological analysis. Upon intravenous administration, NPs selectively accumulated cells. Within tumor, Zn2+ bound intracellular protoporphyrin IX (PpIX) form PpIX-Zn, inhibiting oxygenase-1 (HO-1) activity preventing PpIX into heme. increased effective concentration photosensitizer, thereby enhancing PDT. Additionally, Cu+ catalyzed decomposition excess H2O2 microenvironment, generating hydroxyl radicals, which alleviated hypoxia activated CDT. PDT/CDT effect significantly enhanced growth vivo. effectively selective targeting HO-1 simultaneously leveraging CDT additional suppression. combined strategy superior outcomes, highlighting this nanoplatform as promising approach

Язык: Английский

Multifunctional nanoplatform for tumor chemodynamic and Self-Amplified photodynamic Cascade therapy DOI Creative Commons
Xiaoling Luo, Haifeng Qi, M. Yan

и другие.

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

5-Aminolevulinic acid (5-ALA)-based photodynamic therapy (PDT) has demonstrated considerable potential in breast cancer treatment. However, its efficacy is limited by low tissue selectivity and the rapid conversion of 5-ALA to non-photosensitive heme tumor tissues, reducing therapeutic effectiveness. This study aims develop a multifunctional nanomedicine enhance 5-ALA's PDT while introducing chemodynamic (CDT) for synergistic inhibition. By designing zinc-ion-doped cuprous metal-organic framework (MOF) nanocarrier loaded with (5-ALA@Zn-CuTz), we seek improve targeting, prolong photosensitizer retention, outcomes. To biocompatibility active surface 5-ALA@Zn-CuTz nanoparticles (NPs) was modified platelet membrane (PM), forming 5-ALA@Zn-CuTz@PM NPs. The evaluated vitro vivo using mice models. Cellular uptake, reactive oxygen species (ROS) generation, inhibition efficiency were analyzed through fluorescence imaging, biochemical assays, histological analysis. Upon intravenous administration, NPs selectively accumulated cells. Within tumor, Zn2+ bound intracellular protoporphyrin IX (PpIX) form PpIX-Zn, inhibiting oxygenase-1 (HO-1) activity preventing PpIX into heme. increased effective concentration photosensitizer, thereby enhancing PDT. Additionally, Cu+ catalyzed decomposition excess H2O2 microenvironment, generating hydroxyl radicals, which alleviated hypoxia activated CDT. PDT/CDT effect significantly enhanced growth vivo. effectively selective targeting HO-1 simultaneously leveraging CDT additional suppression. combined strategy superior outcomes, highlighting this nanoplatform as promising approach

Язык: Английский

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