Leveraging artificial intelligence in vaccine development: A narrative review
Journal of Microbiological Methods,
Год журнала:
2024,
Номер
224, С. 106998 - 106998
Опубликована: Июль 15, 2024
Vaccine
development
stands
as
a
cornerstone
of
public
health
efforts,
pivotal
in
curbing
infectious
diseases
and
reducing
global
morbidity
mortality.
However,
traditional
vaccine
methods
are
often
time-consuming,
costly,
inefficient.
The
advent
artificial
intelligence
(AI)
has
ushered
new
era
design,
offering
unprecedented
opportunities
to
expedite
the
process.
This
narrative
review
explores
role
AI
development,
focusing
on
antigen
selection,
epitope
prediction,
adjuvant
identification,
optimization
strategies.
algorithms,
including
machine
learning
deep
learning,
leverage
genomic
data,
protein
structures,
immune
system
interactions
predict
antigenic
epitopes,
assess
immunogenicity,
prioritize
antigens
for
experimentation.
Furthermore,
AI-driven
approaches
facilitate
rational
design
immunogens
identification
novel
candidates
with
optimal
safety
efficacy
profiles.
Challenges
such
data
heterogeneity,
model
interpretability,
regulatory
considerations
must
be
addressed
realize
full
potential
development.
Integrating
emerging
technologies,
single-cell
omics
synthetic
biology,
promises
enhance
precision
scalability.
underscores
transformative
impact
highlights
need
interdisciplinary
collaborations
harmonization
accelerate
delivery
safe
effective
vaccines
against
diseases.
Язык: Английский
Research progress of DNA methylation in the screening of cervical cancer and precancerous lesions
Deleted Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 12, 2025
Abstract
Cervical
cancer
is
one
of
the
most
common
malignant
tumors
that
seriously
threaten
women's
health.
Persistent
infection
with
high
risk
human
papillomavirus
(HPV)
closely
related
to
progression
cervical
cancer.
screening
an
effective
measure
reduce
incidence
and
mortality
The
two
strategies
are
cytology
HPV
testing,
but
they
easily
lead
missed
diagnosis
or
overdiagnosis.
To
overcome
such
limitations,
a
new
triage
method
needs
be
explored.
World
Health
Organization
second
edition
guideline
includes
DNA
methylation
testing
as
evaluated.
epigenetic
modification
considered
occurrence
development
tumors.
In
recent
years,
many
methylated
genes
have
been
found
biomarkers
for
precancerous
lesions
diagnosis.
this
paper,
we
focus
on
role
application
host
methylation,
well
combined
in
lesions.
Язык: Английский
Revolutionizing Cervical Cancer Diagnostics: A Shift from Traditional Techniques to Biosensors
Biosensors and Bioelectronics X,
Год журнала:
2025,
Номер
unknown, С. 100587 - 100587
Опубликована: Янв. 1, 2025
Язык: Английский
Harnessing AI for advancing pathogenic microbiology: a bibliometric and topic modeling approach
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 15, 2024
Introduction
The
integration
of
artificial
intelligence
(AI)
in
pathogenic
microbiology
has
accelerated
research
and
innovation.
This
study
aims
to
explore
the
evolution
trends
AI
applications
this
domain,
providing
insights
into
how
is
transforming
practice
microbiology.
Methods
We
employed
bibliometric
analysis
topic
modeling
examine
27,420
publications
from
Web
Science
Core
Collection,
covering
period
2010
2024.
These
methods
enabled
us
identify
key
trends,
areas,
geographical
distribution
efforts.
Results
Since
2016,
there
been
an
exponential
increase
AI-related
publications,
with
significant
contributions
China
USA.
Our
identified
eight
major
application
areas:
pathogen
detection,
antibiotic
resistance
prediction,
transmission
modeling,
genomic
analysis,
therapeutic
optimization,
ecological
profiling,
vaccine
development,
data
management
systems.
Notably,
we
found
lexical
overlaps
between
these
especially
drug
suggesting
interconnected
landscape.
Discussion
increasingly
moving
laboratory
clinical
applications,
enhancing
hospital
operations
public
health
strategies.
It
plays
a
vital
role
optimizing
improving
diagnostic
speed,
treatment
efficacy,
disease
control,
particularly
through
advancements
rapid
susceptibility
testing
COVID-19
development.
highlights
current
status,
progress,
challenges
microbiology,
guiding
future
directions,
resource
allocation,
policy-making.
Язык: Английский