mRNA vaccine platforms: linking infectious disease prevention and cancer immunotherapy
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Март 12, 2025
The
advent
of
mRNA
vaccines,
accelerated
by
the
global
response
to
COVID-19
pandemic,
marks
a
transformative
shift
in
vaccine
technology.
In
this
article,
we
discuss
development,
current
applications,
and
prospects
vaccines
for
both
prevention
treatment
infectious
diseases
oncology.
By
leveraging
capacity
encode
antigens
within
host
cells
directly,
provide
versatile
scalable
platform
suitable
addressing
broad
spectrum
pathogens
tumor-specific
antigens.
We
highlight
recent
advancements
design,
innovative
delivery
mechanisms,
ongoing
clinical
trials,
with
particular
emphasis
on
their
efficacy
combating
diseases,
such
as
COVID-19,
Zika,
influenza,
well
emerging
potential
cancer
immunotherapy.
also
address
critical
challenges,
including
stability,
optimization
immune
responses,
broader
issue
accessibility.
Finally,
review
strategies
advancing
next-generation
aim
overcoming
limitations
technology
enhancing
preventive
therapeutic
approaches
oncological
diseases.
Язык: Английский
Advancing Eco-friendly Biomedicine: Sustainable Nanocomposites as Platforms for Genetic Vaccines
Опубликована: Янв. 1, 2025
Язык: Английский
Development of ELISA Assay for Antibody Detection in Cancer Vaccine Research
Methods in molecular biology,
Год журнала:
2025,
Номер
unknown, С. 193 - 206
Опубликована: Янв. 1, 2025
Язык: Английский
Into the Future: Fighting Melanoma with Immunity
Cancers,
Год журнала:
2024,
Номер
16(23), С. 4002 - 4002
Опубликована: Ноя. 29, 2024
Immunotherapy
offers
a
novel
and
promising
option
in
the
treatment
of
late-stage
melanoma.
By
utilizing
immune
system
to
assist
tumor
destruction,
patients
have
additional
options
after
progression.
Immune
checkpoint
inhibitors
reduce
ability
for
tumors
evade
by
inhibiting
key
surface
proteins
used
inactivate
T-cells.
Without
these
proteins,
T-cells
can
induce
cytotoxic
responses
against
tumors.
Tumor
infiltrating
lymphocyte
therapy
is
form
adoptive
cell
that
takes
advantage
small
subset
recognize
infiltrate
Isolation
rapid
expansion
colonies
mounting
charged
response
remission.
vaccines
deliver
high
dose
unique
antigens
expressed
cells
entire
body.
The
introduction
large
quantities
upregulates
antigen
presenting
leads
effective
activation
Cytokine
introduces
amounts
chemical
messengers
are
endogenous
support
T-cell
expansion.
While
other
methods
immunotherapy
exist,
inhibitors,
lymphocytes,
vaccines,
cytokine
commonly
treat
Like
many
cancer
treatments,
not
without
adverse
effects,
as
toxicities
represent
major
obstacle.
However,
has
been
efficacious
Язык: Английский