Epigenetic Regulation of Chromatin Functions by MicroRNAs and Long Noncoding RNAs and Implications in Human Diseases DOI Creative Commons
Salvatore Costa, Gaspare La Rocca, Vincenzo Cavalieri

и другие.

Biomedicines, Год журнала: 2025, Номер 13(3), С. 725 - 725

Опубликована: Март 16, 2025

The bulk of RNA produced from the genome complex organisms consists a very large number transcripts lacking protein translational potential and collectively known as noncoding RNAs (ncRNAs). Initially thought to be mere products spurious transcriptional noise, ncRNAs are now universally recognized pivotal players in cell regulatory networks across broad spectrum biological processes. Owing their critical roles, ncRNA dysfunction is closely associated with etiopathogenesis various human malignancies, including cancer. As such, represent valuable diagnostic biomarkers well targets for innovative therapeutic intervention. In this review, we focus on microRNAs (miRNAs) long (lncRNAs), two most extensively studied classes field biology. After outlining key concepts miRNA lncRNA biogenesis pathways, examine multiple roles mediating epigenetic regulation gene expression chromatin organization. Finally, by providing numerous examples specific miRNAs lncRNAs, discuss how dysregulation these mechanisms contributes onset and/or progression diseases.

Язык: Английский

Epigenetic Regulation of Chromatin Functions by MicroRNAs and Long Noncoding RNAs and Implications in Human Diseases DOI Creative Commons
Salvatore Costa, Gaspare La Rocca, Vincenzo Cavalieri

и другие.

Biomedicines, Год журнала: 2025, Номер 13(3), С. 725 - 725

Опубликована: Март 16, 2025

The bulk of RNA produced from the genome complex organisms consists a very large number transcripts lacking protein translational potential and collectively known as noncoding RNAs (ncRNAs). Initially thought to be mere products spurious transcriptional noise, ncRNAs are now universally recognized pivotal players in cell regulatory networks across broad spectrum biological processes. Owing their critical roles, ncRNA dysfunction is closely associated with etiopathogenesis various human malignancies, including cancer. As such, represent valuable diagnostic biomarkers well targets for innovative therapeutic intervention. In this review, we focus on microRNAs (miRNAs) long (lncRNAs), two most extensively studied classes field biology. After outlining key concepts miRNA lncRNA biogenesis pathways, examine multiple roles mediating epigenetic regulation gene expression chromatin organization. Finally, by providing numerous examples specific miRNAs lncRNAs, discuss how dysregulation these mechanisms contributes onset and/or progression diseases.

Язык: Английский

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