Unveiling the tissue-specific landscape of nuclear-encoded mitochondrial genes involved in amino acid metabolism in buffalo DOI Creative Commons

E. M. Sadeesh,

Madhuri S. Lahamge

Amino Acids, Год журнала: 2025, Номер 57(1)

Опубликована: Фев. 28, 2025

Mitochondria play a pivotal role in energy production, metabolism, and cellular signaling, serving as key regulators of functions, including differentiation tissue-specific adaptation. The interplay between mitochondria the nucleus is crucial for coordinating these processes, particularly through supply metabolites epigenetic modifications that facilitate nuclear-mitochondrial interactions. To investigate mitochondrial adaptations at molecular level, we conducted RNA sequencing data analyses kidney, heart, brain, ovary tissues female buffaloes, focusing on variations gene expression related to amino acid metabolism. Our analysis identified 82 nuclear-encoded transcripts involved with significant differential patterns across all tissues. Notably, kidney—tissues higher demands—exhibited elevated levels compared ovary. kidney displayed unique patterns, characterized by up-regulation genes glyoxylate metabolism catabolism. In contrast, comparative heart versus brain revealed shared associated fatty oxidation. Gene ontology KEGG pathway confirmed enrichment pathways degradation These findings highlight regulation linked reflecting distinct metabolic requirements different buffalo. Importantly, our results underscore relevance not only livestock health but also understanding disorders humans. By elucidating mechanisms function their variations, this study provides insights could inform breeding strategies enhanced productivity contribute therapeutic approaches human diseases. Thus, illustrate how are specialized manner optimize utilization maintain homeostasis, implications both animal welfare health.

Язык: Английский

Unveiling the tissue-specific landscape of nuclear-encoded mitochondrial genes involved in amino acid metabolism in buffalo DOI Creative Commons

E. M. Sadeesh,

Madhuri S. Lahamge

Amino Acids, Год журнала: 2025, Номер 57(1)

Опубликована: Фев. 28, 2025

Mitochondria play a pivotal role in energy production, metabolism, and cellular signaling, serving as key regulators of functions, including differentiation tissue-specific adaptation. The interplay between mitochondria the nucleus is crucial for coordinating these processes, particularly through supply metabolites epigenetic modifications that facilitate nuclear-mitochondrial interactions. To investigate mitochondrial adaptations at molecular level, we conducted RNA sequencing data analyses kidney, heart, brain, ovary tissues female buffaloes, focusing on variations gene expression related to amino acid metabolism. Our analysis identified 82 nuclear-encoded transcripts involved with significant differential patterns across all tissues. Notably, kidney—tissues higher demands—exhibited elevated levels compared ovary. kidney displayed unique patterns, characterized by up-regulation genes glyoxylate metabolism catabolism. In contrast, comparative heart versus brain revealed shared associated fatty oxidation. Gene ontology KEGG pathway confirmed enrichment pathways degradation These findings highlight regulation linked reflecting distinct metabolic requirements different buffalo. Importantly, our results underscore relevance not only livestock health but also understanding disorders humans. By elucidating mechanisms function their variations, this study provides insights could inform breeding strategies enhanced productivity contribute therapeutic approaches human diseases. Thus, illustrate how are specialized manner optimize utilization maintain homeostasis, implications both animal welfare health.

Язык: Английский

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