Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities

Neural Plasticity, Год журнала: 2020, Номер 2020, С. 1 - 13

Опубликована: Янв. 27, 2020

With the rise in aging global population, stroke comorbidities have become a serious health threat and tremendous economic burden on human society. Current therapeutic strategies mainly focus protecting neurons from cytotoxic damage at acute phase upon onset, which not only is difficult way to ameliorate symptoms but also presents challenge for patients receive effective treatment time. The brain-derived neurotrophic factor (BDNF) most abundant neurotrophin adult brain, possesses remarkable capability repair brain damage. Recent promising preclinical outcomes made BDNF popular late-stage target development of novel treatments. In this review, we aim summarize latest progress understanding cellular/molecular mechanisms underlying pathogenesis, current difficulties drug development, mechanism action poststroke neurorehabilitation neuroplasticity, recent updates methods.

Язык: Английский

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BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis

Journal of Neuroinflammation, Год журнала: 2020, Номер 17(1)

Опубликована: Янв. 13, 2020

Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) often grieve over a low quality of life brought about by chronic pain. In our previous studies, we determined that neuroinflammation the spinal dorsal horn (SDH) was associated mechanisms cystitis. Moreover, it has been shown brain-derived neurotrophic factor (BDNF) participates in regulation and pathological through BDNF-TrkB signaling; however, whether plays role cyclophosphamide (CYP)-induced cystitis remains unclear. This study aimed to confirm signaling modulates mechanical allodynia CYP-induced determine how occurs.Systemic intraperitoneal injection CYP performed establish rat model. modulated TrkB receptor antagonist, ANA-12, or intrathecal exogenous BDNF. Mechanical suprapubic region assessed using von Frey filaments test. The expression BDNF, TrkB, p-TrkB, Iba1, GFAP, p-p38, p-JNK, IL-1β, TNF-α L6-S1 SDH measured Western blotting immunofluorescence analysis.BDNF-TrkB upregulated significantly after injected. Similarly, expressions were all upregulated. Treatment ANA-12 could attenuate allodynia, restrain activation astrocytes microglia alleviate neuroinflammation. Besides, BDNF further decreased withdrawal threshold, promoted microglia, increased release IL-1β model.In model, aggravating leading BDNF-TrkB-p38/JNK signaling.

Язык: Английский

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The Brain-Derived Neurotrophic Factor: Missing Link Between Sleep Deprivation, Insomnia, and Depression

Neurochemical Research, Год журнала: 2019, Номер 45(2), С. 221 - 231

Опубликована: Ноя. 28, 2019

Язык: Английский

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Sarcopenia and Cognitive Function: Role of Myokines in Muscle Brain Cross-Talk

Life, Год журнала: 2021, Номер 11(2), С. 173 - 173

Опубликована: Фев. 23, 2021

Sarcopenia is a geriatric syndrome characterized by the progressive degeneration of muscle mass and function, it associated with severe complications, which are falls, functional decline, frailty, mortality. cognitive impairment, defined as decline in one or more domains language, memory, reasoning, social cognition, planning, making decisions, solving problems. Although exact mechanism relating to sarcopenia function has not yet been defined, several studies have shown that skeletal produces secrete molecules, called myokines, regulate brain functions, including mood, learning, locomotor activity, neuronal injury protection, showing existence muscle-brain cross-talk. Moreover, conducted on physical exercise supported cross-talk, how changing myokines' circulating levels, exerts beneficial effects brain. The review mainly focuses describing role myokines their involvement impairment sarcopenia.

Язык: Английский

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Effects of physical exercise on plasma brain-derived neurotrophic factor in neurodegenerative disorders: A systematic review and meta-analysis of randomized controlled trials

Neuroscience & Biobehavioral Reviews, Год журнала: 2021, Номер 128, С. 394 - 405

Опубликована: Июнь 1, 2021

Neurodegenerative disorders are associated with reduced levels of brain-derived neurotrophic factor (BDNF). We aimed to assess the effect exercise interventions on plasma BDNF in individuals neurodegenerative disorders. Eighteen randomized controlled trials (RCT) assessing effects versus no (i.e., multiple sclerosis, Parkinson's disease, mild cognitive impairment [MCI] and Alzheimer's disease) were included. Overall, induced a significant increase (SMD=2.22, 95% CI=1.33-3.12, p<0.001; 18 studies), which was separately confirmed for sclerosis (SMD= 2.40, CI= 1.30-3.50, 10 studies) disease 10.00, 2.48-17.51, p=0.009; 3 non-significant trend also observed MCI 1.07, -0.14-2.28, p=0.080; 4 studies). significantly increased regardless type (p<0.001, p=0.003 p=0.020 combined, aerobic resistance exercise, respectively), weekly volume (p<0.001 both ≥150 <150 min/week) intervention length ≥12 <12 weeks). In conclusion, physical PROSPERO registration number: CRD42020199459.

Язык: Английский

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