Developmental Dynamics,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 9, 2024
The
rising
incidence
of
Alzheimer's
disease
(AD)
and
the
associated
economic
impacts
has
prompted
a
global
focus
in
field.
In
recent
years,
there
been
growing
understanding
pathogenic
mechanisms
AD,
including
aggregation
β-amyloid,
hyperphosphorylated
tau,
neuroinflammation.
These
processes
collectively
lead
to
neurodegeneration
cognitive
decline,
which
ultimately
results
loss
autonomy
patients.
Currently,
are
three
main
types
AD
treatments:
clinical
tools,
pharmacological
treatment,
material
interventions.
This
review
provides
comprehensive
analysis
underlying
etiology
pathogenesis
as
well
an
overview
current
prevalence
treatments.
We
believe
this
article
can
help
deepen
our
mechanism,
facilitate
translation
scientific
research
or
therapies,
address
problem
AD.
Next frontier.,
Год журнала:
2024,
Номер
8(1), С. 199 - 199
Опубликована: Ноя. 28, 2024
Epigenetic
modifications
play
a
pivotal
role
in
cellular
differentiation
and
the
onset
of
complex
diseases
by
regulating
gene
expression
without
altering
underlying
DNA
sequence.
Mechanisms
such
as
methylation,
histone
modification,
chromatin
remodeling
orchestrate
transition
from
pluripotent
stem
cells
to
specialized
cell
types,
ensuring
tissue-specific
functionality.
This
research
delves
into
intricate
interplay
between
these
epigenetic
regulators
their
involvement
developmental
processes.
Moreover,
it
examines
how
aberrations
landscapes
contribute
pathogenesis
cancer,
neurodegenerative
disorders,
autoimmune
conditions.
By
employing
advanced
techniques
like
single-cell
epigenomics
CRISPR-based
editing,
this
study
aims
uncover
novel
biomarkers
therapeutic
targets.
The
findings
highlight
dynamic
reversible
nature
marks,
offering
promising
avenues
for
personalized
medicine.
Understanding
disease
development
is
essential
advancing
diagnostics,
therapeutics,
our
broader
understanding
human
biology.
Developmental Dynamics,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 9, 2024
The
rising
incidence
of
Alzheimer's
disease
(AD)
and
the
associated
economic
impacts
has
prompted
a
global
focus
in
field.
In
recent
years,
there
been
growing
understanding
pathogenic
mechanisms
AD,
including
aggregation
β-amyloid,
hyperphosphorylated
tau,
neuroinflammation.
These
processes
collectively
lead
to
neurodegeneration
cognitive
decline,
which
ultimately
results
loss
autonomy
patients.
Currently,
are
three
main
types
AD
treatments:
clinical
tools,
pharmacological
treatment,
material
interventions.
This
review
provides
comprehensive
analysis
underlying
etiology
pathogenesis
as
well
an
overview
current
prevalence
treatments.
We
believe
this
article
can
help
deepen
our
mechanism,
facilitate
translation
scientific
research
or
therapies,
address
problem
AD.
