Treatment of neuropathic pain by traditional Chinese medicine: An updated review on their effect and putative mechanisms of action

Phytotherapy Research, Год журнала: 2024, Номер 38(6), С. 2962 - 2992

Опубликована: Апрель 10, 2024

Abstract Neuropathic pain (NP) is a common chronic with heterogeneous clinical features, and consequent lowering of quality life. Currently, although conventional chemical drugs can effectively manage NP symptoms in the short term, their long‐term efficacy limited, they come significant side effects. In this regard, traditional Chinese medicine (TCM) provides promising avenue for treating NP. Numerous pharmacological studies have substantiated effectiveness TCM multiple targets mechanisms. We aimed to outline characteristics TCM, including compound prescriptions, single herbs, active ingredients, physical therapy, treatment discussed by analyzing pathogenesis Various databases, such as PubMed, Web Science, China National Knowledge Infrastructure, Wanfang database, were searched. focused on recent research progress TCM. Finally, we proposed future challenges emerging trends demonstrates treatment, employing multi‐mechanisms. Drawing from theory syndrome differentiation, four types dialectical treatments prescriptions introduced: promoting blood circulation removing stasis; promote Qi flow; warming Yang benefiting Qi; soothing liver regulating Qi. Meanwhile, 33 herbs 25 ingredients included. addition, therapy (e.g., acupuncture, massage, acupoint injection, fumigation) also showed good treatment. particularly through use holds bright prospects owing its diverse holistic Nonetheless, multi‐targets may result possible disadvantages mechanisms need further evaluation. Here, provide an overview via based potential therapeutic mechanisms, thus providing reference studies.

Язык: Английский

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Blood exosome connexins and small RNAs related to demyelinating disease activity

Annals of Clinical and Translational Neurology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Abstract Objectives To assess blood exosome (Ex)‐connexin (Cx)43 (encoded by GJA1 ) and its truncated isoforms in multiple sclerosis (MS) neuromyelitis optica spectrum disorder (NMOSD), which show distinct alterations astroglial Cx43. Methods Serum Exs from 48 patients with MS (34 relapsing–remitting, 14 secondary‐progressive), 35 NMOSD, 20 other inflammatory neurologic diseases (OIND), 17 healthy controls (HC) were subjected to quantitative Western blotting for Cx43, single‐molecule array neurofilament‐L, polymerase chain reaction non‐coding RNAs detected RNA sequencing. Sera control astroglia‐specific Cx43 inducible conditional knockout ( Cx43‐icKO mice experimental autoimmune encephalomyelitis (EAE) also tested. Results Ex‐GJA1‐29k was markedly higher than OIND, HC; it successively increased at relapse, remission, secondary progression, positively correlated disability scores. Ex‐hsa‐miR‐133b hsa‐miRs that bind full‐length significantly lower secondary‐progressive HC, negatively Ex‐GJA1‐11k expression NMOSD relapse HC score worsening Ex‐neurofilament‐L levels. had of small nucleolar (SNORD37, SNORD95, SNORD97) SNORD37 SNORD95 showed strong negative correlations Control Ex‐GJA1‐43k ‐29k during EAE; this effect reduced attenuated EAE. Interpretation Blood Ex‐Cx43‐truncated RNAs, partially come brain astroglia, are distinctly dysregulated NMSOD.

Язык: Английский

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Role of spinal Barrier-to-Autointegration Factor (BAF) in the epigenetic silencing of the mu-opioid receptor gene in neuropathic pain

Regional Anesthesia & Pain Medicine, Год журнала: 2025, Номер unknown, С. rapm - 106004

Опубликована: Фев. 6, 2025

Background Neuropathic pain presents a significant clinical challenge, with spinal cord epigenetic mechanisms playing critical role in its development. This study investigated the impact of nerve injury on Barrier-to-Autointegration Factor (BAF) rat dorsal horn. Methods Adult Sprague-Dawley rats underwent ligation (SNL) to model neuropathic pain. Pain behaviors were assessed using von Frey and burrow tests. Biochemical analyses measured mRNA protein expression Results SNL elevated BAF levels, which interacts LEM domain–containing 2 (LEMD2), activating histone-modifying enzyme EZH2. adds gene-silencing mark, H3K27me3, promoter region Oprm1 gene, encodes mu-opioid receptor. Consequently, receptor is decreased, potentially contributing Using gene knockdown techniques reduce expression, we reversed changes LEMD2, EZH2, expressions induced by attenuated mechanical allodynia. Additionally, knocking down LEMD2 disrupted binding promoter, without affecting levels. Inhibiting EZH2 also signaling altering Glutamate activated pathways via pNR2B receptors, NR2B blockade this effect. Conclusion These findings suggest that receptors may activate BAF, enhance EZH2-mediated H3K27me3 at after injury. Targeting pathway offer novel strategies inhibit

Язык: Английский

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Spinal astrocytes involved in the pathogenesis and treatment of neuropathic pain

Frontiers in Cellular Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Фев. 21, 2025

Neuropathic pain is a common and severe type of chronic pain, its pathogenesis has not been fully defined. Increasing evidence shows that spinal astrocytes play indispensable roles in the occurrence development neuropathic pain. Most studies have suggested activated can crosstalk with other glial cells neurons through morphological functional changes, exacerbating However, reactive dual role. As defense mechanism, increasing neuroprotection stimulating neurogenesis. Studies demonstrated potentially beneficial role for astrocyte activation In addition, therapeutic mechanisms multiple drugs neuromodulatory techniques are thought to be related astrocytes. This review highlights recent advances significance astrocytes, emphasizing need better understanding their treatment

Язык: Английский

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Intravesical Botulinum Toxin Injection Plus Hydrodistention Is More Effective in Patients with Bladder Pain-Predominant Interstitial Cystitis/Bladder Pain Syndrome

Toxins, Год журнала: 2024, Номер 16(2), С. 74 - 74

Опубликована: Фев. 1, 2024

Intravesical botulinum toxin A (BoNT-A) injections are included in the interstitial cystitis/bladder pain syndrome (IC/BPS) treatment guidelines. However, IC phenotype suitable for with BoNT-A has not been clarified. Therefore, we identified factors influencing outcomes intravesical patients non-Hunner IC/BPS (NHIC). This retrospective study NHIC who underwent 100 U over past two decades. Six months after treatment, were assessed using Global Response Assessment (GRA). Outcome endpoints GRA, clinical symptoms, urodynamic parameters, urine biomarkers, and identification of contributing to satisfactory outcomes. The 220 (42 men, 178 women). group (n = 96, 44%) had significantly higher severity scores symptoms index, larger maximum bladder capacity (MBC), lower 8-isoprostane levels at baseline. Logistic regression revealed that MBC (≥760 mL) predominance associated injection. Subjective parameters improved pain-predominant Thus, or pelvic more likely experience following injections.

Язык: Английский

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Interactions and Trends of Interleukins, PAI-1, CRP, and TNF-α in Inflammatory Responses during the Perioperative Period of Joint Arthroplasty: Implications for Pain Management—A Narrative Review

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(5), С. 537 - 537

Опубликована: Май 17, 2024

Inflammation during the perioperative period of joint arthroplasty is a critical aspect patient outcomes, influencing both pathophysiology pain and healing process. This narrative review comprehensively evaluates roles specific cytokines inflammatory biomarkers in this context their implications for management. Inflammatory responses are initiated propagated by cytokines, which pivotal development acute chronic postoperative pain. Pro-inflammatory play essential up-regulating response, which, if not adequately controlled, leads to sustained impaired tissue healing. Anti-inflammatory work dampen promote resolution. Our discussion extends genetic molecular influences on cytokine production, influence perception recovery rates post-surgery. Furthermore, role PAI-1 modulating inflammation through its impact fibrinolytic system highlights potential as therapeutic target. The modulation these various analgesic anesthetic techniques, including fascia iliac compartment block, demonstrates significant reduction markers, thus underscoring importance targeted strategies. analysis suggests that nuanced understanding interplay between pro-inflammatory anti-inflammatory required. Future research should focus individualized management

Язык: Английский

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Novel drug treatments for pain in advanced cancer and serious illness: a focus on neuropathic pain and chemotherapy-induced peripheral neuropathy

Palliative Care and Social Practice, Год журнала: 2024, Номер 18

Опубликована: Янв. 1, 2024

Drugs that are commercially available but have novel mechanisms of action should be explored as analgesics. This review will discuss haloperidol, miragabalin, palmitoylethanolamide (PEA), and clonidine adjuvant analgesics or Haloperidol is a sigma-1 receptor antagonist. Under stress neuropathic injury, receptors act chaperone protein, which downmodulates opioid activities opens several ion channels. Clinically, there only low-grade evidence haloperidol improves pain when combined with morphine, methadone, tramadol in patients who cancer, from fibrosis, radiation necrosis, pain. Miragabalin gabapentinoid approved for the treatment Japan since 2019. In randomized trials, diabetic neuropathy responded to miragabalin. Its long binding half-life on calcium channel subunit may provide an advantage over other gabapentinoids. PEA belongs group endogenous bioactive lipids called ALIAmides (autocoid local injury antagonist amides), sense role modulating numerous biological processes particular non-neuronal neuroinflammatory responses systemic inflammation. Multiple trials meta-analyses demonstrated PEA’s effectiveness reducing severity arising diverse phenotypes. Clonidine alpha2 adrenoceptor agonist imidazoline2 agonist, U.S. Federal Drug Administration attention deficit hyperactivity disorder children, Tourette’s syndrome, adjunctive therapy cancer-related pain, hypertension. activation at adrenoceptors causes downstream inhibitory G-proteins (Gi/Go), inhibits cyclic Adenosine monophosphate (AMP) production hyperpolarizes neuron membranes, thus allodynia. Intravenous has been used terminally ill poorly controlled symptoms, agitation.

Язык: Английский

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Sigma-1 receptor targeting inhibits connexin 43 based intercellular communication in chronic neuropathic pain

Inflammation Research, Год журнала: 2024, Номер 73(10), С. 1711 - 1726

Опубликована: Авг. 2, 2024

Neuropathic pain is a chronic condition characterized by aberrant signaling within the somatosensory system, affecting millions of people worldwide with limited treatment options. Herein, we aim at investigating potential sigma-1 receptor (σ1R) antagonist in managing neuropathic pain.

Язык: Английский

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Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study

Journal of Neuroimmune Pharmacology, Год журнала: 2024, Номер 19(1)

Опубликована: Авг. 20, 2024

Язык: Английский

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Novel sigma 1-antagonists with cis-(+)-normetazocine scaffold: synthesis, molecular modeling, and antinociceptive effect

RSC Medicinal Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 29, 2024

Compound 7 exhibited high σ1R affinity and selectivity produced a potent antinociceptive effect in mouse model of inflammatory pain. Molecular modeling studies were performed to analyze its key interactions with σ1R.

Язык: Английский

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