Complex Probiotics Relieve Constipation Through Regulation of the Intestinal Microbiota in Kittens

Microorganisms, Год журнала: 2025, Номер 13(3), С. 563 - 563

Опубликована: Март 1, 2025

The early developmental phase is a critical window for feline growth, during which immature digestive systems are susceptible to microbiome imbalances caused by environmental stressors. Our research employed macrogenomic analysis evaluate how complex probiotic formulations influence growth metrics and gastrointestinal flora in juvenile felines. Two dozen healthy kittens were equally divided into the control group probiotics following 5-day adaptation phase. Fecal scores recorded daily all kittens. Fresh fecal samples collected on days 1 14 analysis. results showed significantly lower rate of constipation compared (p < 0.05). However, no significant differences observed intestinal microbial diversity or structure between two groups. Metagenomic revealed higher relative abundance Bifidobacterium animalis Additionally, exhibited abundances Lachnospiraceae bacterium 2 58FAA, 57FAA, Acidaminococcus intestini These suggest that can regulate microbiota, improve constipation, promote health

Язык: Английский

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Balancing Act: Exploring the Gut Microbiota-Brown Adipose Tissue Axis in PCOS Pathogenesis and Therapeutic Frontiers

Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(6)

Опубликована: Май 30, 2024

Polycystic ovary syndrome (PCOS) is a prevalent reproductive, endocrine, and metabolic disease that affects 5–18% of women worldwide, with rising incidence. Hyperandrogenemia insulin resistance are two key pathophysiological factors contribute to PCOS, both which variety health issues such as menstrual irregularities, obesity, dysfunctional glucose lipid homeostasis, infertility, mental disorders, cardiovascular cerebrovascular diseases. Despite ongoing studies, the origin pathogenesis PCOS remain elusive; there also clinical need for simpler, more effective, longer lasting, comprehensive treatments PCOS. The gut–fat axis, critical regulatory route metabolism, endocrine function, immune response, has received considerable interest in recent years research etiology treatment illnesses type 2 diabetes mellitus non-alcoholic fatty liver disease. latest revealed significant alterations homogeneity phylogenetic diversity gut microbiota. Animal using fecal microbiota transplantation confirmed importance regulating sensitivity sex hormone balance Furthermore, studies have shown decrease volume and/or activity brown adipose tissue (BAT) patients, change alters adipokine release, leading hyperandrogenemia, aggravating progression. Given function BAT increasing energy expenditure alleviating parameters, efforts activate or induce browning white emerged possible Recent suggested can influence creation via metabolites short-chain acids bile acids, well gut–brain axis. Cold exposure, healthy dieting, metformin, bariatric surgery, glucagon-like peptide 1 receptor agonists melatonin all been basic modulate by influencing microbiota, demonstrating potential. However, into regulation mechanisms gut–BAT axis required produce comfortable, safe tailored therapeutics

Язык: Английский

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Polycystic Ovarian Syndrome: A Review of Multi-omics Analyses

Reproductive Sciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Язык: Английский

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A shotgun metagenomic study identified short-chain fatty acid-producing species and their functions in the gut microbiome of adults with depressive symptoms: Large-scale shotgun sequencing data of the gut microbiota using a cross-sectional design

Journal of Affective Disorders, Год журнала: 2025, Номер 376, С. 26 - 35

Опубликована: Янв. 31, 2025

Язык: Английский

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Oxyberberine Revokes Letrozole-induced Polycystic Ovarian Syndrome and Depression-like Behavior in Female Sprague-Dawley Rats

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177613 - 177613

Опубликована: Апрель 1, 2025

Язык: Английский

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Potential causal association between the oral microbiome and bipolar disorder

Journal of Affective Disorders, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Microbiota-Short Chain Fatty Acid Relationships and Microbial Substrate Preferences Vary Across the Spectrum of Irritable Bowel Syndrome (IBS)

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 1, 2024

ABSTRACT Background Identifying microbial targets in irritable bowel syndrome (IBS) and other disorders of gut-brain interaction (DGBI) is challenging due to the dynamic nature microbiota-metabolite-host interactions. SCFA are key metabolites that modulate intestinal homeostasis may influence IBS pathophysiology. We aimed assess features associated with short chain fatty acids (SCFA) determine if varied across subtypes endophenotypes. Among 96 participants who were screened, 71 completed study. conducted in-depth investigations stool metagenomes, SCFA, measurable traits (stool bile acids, colonic transit, form) 41 patients (IBS constipation [IBS-C] diarrhea [IBS-D]) 17 healthy controls. used partial canonical correspondence analyses (pCCA), conditioned on quantify microbe-SCFA associations clinical groups. To explore relationships between microbially-derived traits, we compared gut microbiome-encoded potential for substrate utilization groups within a subset selected by their characteristics as well microbiomes without acid malabsorption. Results Overall microbiome composition individual taxa abundances differed Microbes-SCFA revealed including Dorea sp. CAG:317 Bifidobacterium pseudocatenulatum IBS-D Akkermansia muciniphila Prevotella copri IBS-C drive subtype-specific microbially-mediated mechanisms. Strongest observed several SCFA-producing species surprisingly demonstrated inverse correlations SCFA. Fewer bacterial acetate butyrate ratios health. In form, differential genes/pathways metabolism degradation carbohydrates mucin reduced BAM. Conclusion Keystone responsible production differ according subtype characterized functional redundancy. Differences preferences also linked functions. Focusing profiles form be rational strategy identifying relevant DGBI.

Язык: Английский

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Full-length 16S rDNA sequencing based on Oxford Nanopore Technologies revealed the association between gut-pharyngeal microbiota and tuberculosis in cynomolgus macaques

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 10, 2024

Tuberculosis (TB) is an infectious disease caused by the Mycobacterium tuberculosis complex (Mtbc), which develops from asymptomatic latent TB to active stages. The microbiome was purposed as a potential factor affecting pathogenesis, but study limited. present explored association between gut-pharyngeal and stages in cynomolgus macaques using full-length 16S rDNA amplicon sequencing based on Oxford Nanopore Technologies. total of 71 divided into (-) control, (+) groups. differential abundance analysis showed that Haemophilus hemolyticus decreased, while Prevotella species were increased pharyngeal macaques. In addition, Eubacterium coprostanoligenes gut enriched Alteration these bacteria might affect immune regulation severity, details mechanisms should be further validated. summary, microbiota may associated with host progression. findings suggested host-microbes interaction, improve understanding role help develop therapeutics for future.

Язык: Английский

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Dietary Factors and the Risk of Depression among Women with Polycystic Ovary Syndrome

Nutrients, Год журнала: 2024, Номер 16(6), С. 763 - 763

Опубликована: Март 7, 2024

This study aimed to assess the association between dietary factors and depression in a group of polycystic ovary syndrome (PCOS) women evaluate potential interactions mediating role BMI this relationship. One hundred sixteen with PCOS were asked complete Dietary Habits Nutrition Beliefs Questionnaire manual for developing nutritional data (KomPAN questionnaire) Beck Depression Inventory. The population was divided into two groups: (1) not at risk (ND), n = 61, (2) (RD), 55. Significantly higher values observed RD than ND group. In group, intake vegetables legumes lower LD but consumption sweet beverages energy drinks higher. Consumption least twice per day is known be associated 62% probability women. Furthermore, overweight obesity have 5.82 times greater chance normal body weight. Our findings show that there significant certain factors, BMI, symptoms

Язык: Английский

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Cleome arabica L mitigates bisphenol A-induced ovarian dysfunction and inflammation in Wistar rats: biochemical, histopathological, pharmacokinetic, and in silico studies

3 Biotech, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 23, 2024

Язык: Английский

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