Disruptions in cellular communication: Molecular interplay between glutamate/NMDA signalling and MAPK pathways in neurological disorders

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Molecular Mechanisms of the Effects of Photodynamic Therapy on the Brain: A Review of the Literature

Photodiagnosis and Photodynamic Therapy, Год журнала: 2025, Номер unknown, С. 104536 - 104536

Опубликована: Фев. 1, 2025

Malignant gliomas are the most common primary brain tumors in adults. These have a diverse molecular origin and very poor prognosis. There is lack of effective treatment at WHO grade IV glioma, all glioblastomas progress or recur. Current treatments including surgical intervention, radiation therapy, chemotherapy insufficient can cause damage to healthy tissue neurological deficits. The preservation during therapeutic intervention made extremely difficult by ability malignant diffusely infiltrate surrounding parenchyma. Photodynamic therapy (PDT) modality for glioma that possibly overcome inherent shortcommings traditional therapies. involves use photosensitizer (PS) which, upon absorption light photosensitized tissue, triggers photochemical reactions generating reactive oxygen species (ROS) leading killing tumor cells. Research focusing on PDT already underway with promising results. Clinical studies shown it be safe acceptable levels side effects. However, some adverse sequelae been observed these tumours, such as increased photosensitivity, intracranial pressure transient aphasia worsening pre-existing Although clinical well described, mechanisms PDT's effects not yet thoroughly characterized. In our work, we attempt summarize photosensitization neural vasculature blood-brain barrier (BBB). We also point findings presenting approaches protect from photodynamic damage.

Язык: Английский

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Navigating the Complexities of Neuronal Signaling and Targets in Neurological Disorders: From Pathology to Therapeutics

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177417 - 177417

Опубликована: Фев. 1, 2025

Язык: Английский

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Therapeutic potential of Baicalin against experimental obsessive compulsive disorder: Evidence from CSF, blood plasma, and brain analysis

Journal of Neuroimmunology, Год журнала: 2025, Номер unknown, С. 578598 - 578598

Опубликована: Март 1, 2025

Язык: Английский

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Therapeutic Potential of Oleanolic acid in Modulation of PI3K/Akt/mTOR/STAT-3/GSK-3β Signaling Pathways and Neuroprotection against Methylmercury-Induced Neurodegeneration

Neurochemistry International, Год журнала: 2024, Номер 180, С. 105876 - 105876

Опубликована: Окт. 3, 2024

Язык: Английский

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Synthesis and Neurobehavioral Evaluation of a Potent Multitargeted Inhibitor for the Treatment of Alzheimer’s Disease

Molecular Neurobiology, Год журнала: 2024, Номер unknown

Опубликована: Июль 15, 2024

Язык: Английский

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Therapeutic efficacy of Genistein in activation of neuronal AC/cAMP/CREB/PKA and mitochondrial ETC-Complex pathways in experimental model of autism: Evidence from CSF, blood plasma and brain analysis

Brain Research, Год журнала: 2024, Номер 1846, С. 149251 - 149251

Опубликована: Окт. 9, 2024

Язык: Английский

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