Human-specific gene ARHGAP11B—potentially an additional tool in the treatment of neurodegenerative diseases? DOI Creative Commons
Wieland Β. Huttner

Frontiers in Molecular Medicine, Год журнала: 2024, Номер 4

Опубликована: Ноя. 27, 2024

One strategy in the treatment of neurodegenera=ve diseases has been towards replenishing lost cells, notably neurons. Approaches taken to this end have included following. First, either ac=vate neural stem cells that endogenously exist certain neurogenic niches adult human brain, such new neurons are being generated where needed (for recent reviews, see (Temple, 2023, Vassal et al., 2024, Velikic 2024)). Second, graS exogenous and/or exogenously into affected brain region, oSen by making use pa=ent-derived induced pluripotent (iPSCs) obtain former (Lee Temple, Vadodaria 2020)).In brief Opinion Ar=cle, I would like draw aXen=on human-specific gene ARHGAP11B, which exhibits proper=es could poten=ally be beneficial diseases.ARHGAP11B is typically referred as a gene. This statement correct with regard extant species, ARHGAP11B does not occur any other primate nor mammal. However, from an evolu=onary point view, actually homininspecific gene, it shown occurred Neandertals and Denisovans, light its origin ≈5 mya likely members Homo lineage review, (HuXner 2024)).A key feature addi=onal tool pertains cell types expressed. Thus, fetal neocortex, exhibi=ng highest level expression progenitor cells. Specifically, expressed both apical progenitors residing ventricular zone basal subventricular zone, radial glia (or outer) glia, respec=vely (Florio 2015). Such can seen strategic advantage if one intends cor=cal for therapeu=c approaches aim achieve replacement. Indeed, poten=al clinical relevance, various animal model systems vivo amplify progenitors, generate 2015, Kalebic 2018, Heide 2020, Xing 2021). Moreover, ARHGAP11B's effects on result increase neuron produc=on Of note, increases so-called upper-layer neurons, class implicated higher cogni=ve abili=es (Kalebic The amplifica=on based ability induce self-renewal 2020). Hence, fulfills criterion applica=on replenishment strategies -the induce, vivo, those neurons.To explore diseases, considered include following two. at targe=ng endogenous appropriate vector. Neural neurogenesis so far detected hippocampus (KempermannSong Gage, 2015)), amygdala (Roeder 2022), lateral ventricles summary, (Baig 2024). An vector should inducible on-off system first respec=ve switching thereaSer, upon off expression, allow them neurons.A second line approach make iPSCs converted then introduced. capacity administered region interest, followed local above.Should transient (i.e., inducible) indeed lead and, consequently, replenishment, future task will determine whether newly able func=onally compensate If so, forward-looking consider mechanism underlying protein imported matrix mitochondria expressing s=mulates metabolic pathway called glutaminolysis (Namba In emerging concept changes metabolism exert crucial impact behaviour 2021), specific pathways may aid endeavours diseases.

Язык: Английский

Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy DOI Creative Commons
Yang Xu, YangQuan Chen,

Jia‐xin Xing

и другие.

Clinical Epigenetics, Год журнала: 2025, Номер 17(1)

Опубликована: Янв. 24, 2025

Enriched environment (EE), as a non-pharmacological intervention, has garnered considerable attention for its potential to ameliorate neurodegenerative diseases (NDs). This review delineated the impact of EE on biological functions associated with NDs, emphasizing role in enhancing neural plasticity, reducing inflammation, and bolstering cognitive performance. We discussed molecular underpinnings effects EE, including modulation key signaling pathways such extracellular regulated kinase 1/2 (ERK1/2), mitogen-activated protein kinases (MAPK), AMPK/SIRT1, which were implicated neuroprotection synaptic plasticity. Additionally, we scrutinized influence epigenetic modifications autophagy, processes pivotal ND pathogenesis. Animal models, encompassing both rodents larger animals, offer insights into disease-modifying underscoring complementary approach pharmacological interventions. In summary, emerges promising strategy augment function decelerate progression NDs.

Язык: Английский

Процитировано

1
Use of Nicotinamide Mononucleotide as Non-Natural Cofactor DOI Open Access
Tahseena Naaz, Beom Soo Kim

Catalysts, Год журнала: 2025, Номер 15(1), С. 37 - 37

Опубликована: Янв. 3, 2025

Nicotinamide mononucleotide (NMN) has emerged as a promising non-natural cofactor with significant potential to transform biocatalysis, synthetic biology, and therapeutic applications. By modulating NAD⁺ metabolism, NMN offers unique advantages in enzymatic reactions, metabolic engineering, regenerative medicine. This review provides comprehensive analysis of NMN’s biochemical properties, mechanisms action, diverse Emphasis is placed on its role addressing challenges multi-enzyme cascades, biofuel production, the synthesis high-value chemicals. The paper also highlights critical research gaps, including need for scalable methods, improved integration into systems, toxicity studies use. Emerging technologies such AI-driven enzyme design CRISPR-based genome engineering are discussed transformative tools optimizing NMN-dependent pathways. Furthermore, synergistic biology innovations, cell-free systems dynamic regulatory networks, explored, paving way precise modular biotechnological solutions. Looking forward, versatility positions it pivotal tool advancing sustainable bioprocessing precision Addressing current limitations through interdisciplinary approaches will enable redefine boundaries innovation. serves roadmap leveraging across scientific industrial domains.

Язык: Английский

Процитировано

0
The neuroplastic brain: current breakthroughs and emerging frontiers DOI Creative Commons
Parisa Gazerani

Brain Research, Год журнала: 2025, Номер unknown, С. 149643 - 149643

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Nanomedicine in Neuroprotection, Neuroregeneration, and Blood–Brain Barrier Modulation: A Narrative Review DOI Creative Commons

Antea Kršek,

Ana Jagodic,

Lara Batičić

и другие.

Medicina, Год журнала: 2024, Номер 60(9), С. 1384 - 1384

Опубликована: Авг. 24, 2024

Nanomedicine is a newer, promising approach to promote neuroprotection, neuroregeneration, and modulation of the blood–brain barrier. This review includes integration various nanomaterials in neurological disorders. In addition, gelatin-based hydrogels, which have huge potential due biocompatibility, maintenance porosity, enhanced neural process outgrowth, are reviewed. Chemical modification these especially with guanidine moieties, has shown improved neuron viability underscores tailored biomaterial design applications. further discusses strategies modulate barrier—a factor critically associated effective delivery drugs central nervous system. These advances bring supportive solutions solving conditions innovative therapies for their treatment. Nanomedicine, as applied neuroscience, presents significant leap forward new therapeutic that might help raise treatment management disorders much better levels. Our aim was summarize current state-of-knowledge this field.

Язык: Английский

Процитировано

3
Nabelschnurspende und perinatale Stammzellen DOI

Christian Breymann

gynäkologie + geburtshilfe, Год журнала: 2024, Номер 29(S1), С. 32 - 35

Опубликована: Сен. 1, 2024

Процитировано

0
Human-specific gene ARHGAP11B—potentially an additional tool in the treatment of neurodegenerative diseases? DOI Creative Commons
Wieland Β. Huttner

Frontiers in Molecular Medicine, Год журнала: 2024, Номер 4

Опубликована: Ноя. 27, 2024

One strategy in the treatment of neurodegenera=ve diseases has been towards replenishing lost cells, notably neurons. Approaches taken to this end have included following. First, either ac=vate neural stem cells that endogenously exist certain neurogenic niches adult human brain, such new neurons are being generated where needed (for recent reviews, see (Temple, 2023, Vassal et al., 2024, Velikic 2024)). Second, graS exogenous and/or exogenously into affected brain region, oSen by making use pa=ent-derived induced pluripotent (iPSCs) obtain former (Lee Temple, Vadodaria 2020)).In brief Opinion Ar=cle, I would like draw aXen=on human-specific gene ARHGAP11B, which exhibits proper=es could poten=ally be beneficial diseases.ARHGAP11B is typically referred as a gene. This statement correct with regard extant species, ARHGAP11B does not occur any other primate nor mammal. However, from an evolu=onary point view, actually homininspecific gene, it shown occurred Neandertals and Denisovans, light its origin ≈5 mya likely members Homo lineage review, (HuXner 2024)).A key feature addi=onal tool pertains cell types expressed. Thus, fetal neocortex, exhibi=ng highest level expression progenitor cells. Specifically, expressed both apical progenitors residing ventricular zone basal subventricular zone, radial glia (or outer) glia, respec=vely (Florio 2015). Such can seen strategic advantage if one intends cor=cal for therapeu=c approaches aim achieve replacement. Indeed, poten=al clinical relevance, various animal model systems vivo amplify progenitors, generate 2015, Kalebic 2018, Heide 2020, Xing 2021). Moreover, ARHGAP11B's effects on result increase neuron produc=on Of note, increases so-called upper-layer neurons, class implicated higher cogni=ve abili=es (Kalebic The amplifica=on based ability induce self-renewal 2020). Hence, fulfills criterion applica=on replenishment strategies -the induce, vivo, those neurons.To explore diseases, considered include following two. at targe=ng endogenous appropriate vector. Neural neurogenesis so far detected hippocampus (KempermannSong Gage, 2015)), amygdala (Roeder 2022), lateral ventricles summary, (Baig 2024). An vector should inducible on-off system first respec=ve switching thereaSer, upon off expression, allow them neurons.A second line approach make iPSCs converted then introduced. capacity administered region interest, followed local above.Should transient (i.e., inducible) indeed lead and, consequently, replenishment, future task will determine whether newly able func=onally compensate If so, forward-looking consider mechanism underlying protein imported matrix mitochondria expressing s=mulates metabolic pathway called glutaminolysis (Namba In emerging concept changes metabolism exert crucial impact behaviour 2021), specific pathways may aid endeavours diseases.

Язык: Английский

Процитировано

0