The Impact of Microbiota on Neurological Disorders: Mechanisms and Therapeutic Implications

OBM Neurobiology, Год журнала: 2025, Номер 09(01), С. 1 - 12

Опубликована: Фев. 28, 2025

Interactions in the gut-brain crosstalk have led to development of an entirely new concept: "microbiota-gut-brain axis". Microbiota has gained considerable attention relation disorders a more neurological nature, such as neurodevelopmental and neuropsychiatric illnesses like autism spectrum disorder, anxiety, mood disorders. This review aims summarize recent trends insights into role consequences gut microbiota brain health pediatric Dysbiosis may be associated with increased risk diseases that lead different disruptions conditions, including mental issues. During dysbiosis, neuropsychological stress hormones usually affect oxytocin GABA neurons are significantly reduced. Current studies report major depression, cognitive dysfunction closely dysbiosis. In last few years, handful clinical emerged, illustrating potential for bidirectional relationship interactions humans. Perhaps some most crucial investigations demonstrating overlapping relationships human axis come from trials focusing on modulating noting significant correlates. A field is emerging gene-editing technology could represent tool improve microbial characteristics. approach particularly relevant neurodegenerative brain-gut linked loss species and/or high pathobiont load.

Язык: Английский

Mental Health Disorders Following Exposure to Endocrine Disruptor Chemicals

OBM Neurobiology, Год журнала: 2025, Номер 09(02), С. 1 - 16

Опубликована: Апрель 18, 2025

There is growing scientific concern regarding how endocrine-disrupting chemicals (EDCs) impact central nervous system (CNS) disorders. Both anecdotal and preclinical studies suggest a link between EDC exposure major depressive disorder (MDD), potentially leading to neurodegenerative outcomes. EDCs primarily exhibit their biological effects by interacting with hormone receptors. Nonetheless, there evidence pointing dysfunction in the hypothalamic-pituitary-gonadal-adrenal axis, which linked neuropsychiatric conditions. Additionally, global incidence of MDD has risen. Various factors like gender, genetic components, age, hormonal balance, cultural influences may explain differences prevalence. Recently, environmental pollutants such as industrial chemicals, emollients, plastics, fungicides, pesticides have emerged critical influencing this disorder. This review delves into influence key phthalate bisphenol compounds on chronic inflammation MDD.

Язык: Английский

The Effect of Exercise on Depression and Gut Microbiota: Possible Mechanisms

Brain Research Bulletin, Год журнала: 2024, Номер unknown, С. 111130 - 111130

Опубликована: Ноя. 1, 2024

Язык: Английский