A multisociety Delphi consensus statement on new fatty liver disease nomenclature

Journal of Hepatology, Год журнала: 2023, Номер 79(6), С. 1542 - 1556

Опубликована: Июнь 24, 2023

The principal limitations of the terms NAFLD and NASH are reliance on exclusionary confounder use potentially stigmatising language. This study set out to determine if content experts patient advocates were in favour a change nomenclature and/or definition. A modified Delphi process was led by three large pan-national liver associations. consensus defined priori as supermajority (67%) vote. An independent committee external made final recommendation acronym its diagnostic criteria. total 236 panellists from 56 countries participated 4 online surveys 2 hybrid meetings. Response rates across survey rounds 87%, 83%, 78%, respectively. Seventy-four percent respondents felt that current sufficiently flawed consider name change. "nonalcoholic" "fatty" be 61% 66% respondents, Steatotic disease chosen an overarching term encompass various aetiologies steatosis. steatohepatitis important pathophysiological concept should retained. replace metabolic dysfunction-associated steatotic (MASLD). There definition include presence at least 1 5 cardiometabolic risk factors. Those with no parameters known cause deemed have cryptogenic disease. new category, outside pure disease, termed alcohol related/associated (MetALD), selected describe those who consume greater amounts per week (140-350 g/wk 210-420 for females males, respectively). criteria widely supported non-stigmatising, can improve awareness identification.

Язык: Английский

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Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2020, Номер 18(4), С. 223 - 238

Опубликована: Дек. 21, 2020

Язык: Английский

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A multisociety Delphi consensus statement on new fatty liver disease nomenclature

Hepatology, Год журнала: 2023, Номер 78(6), С. 1966 - 1986

Опубликована: Июнь 22, 2023

The principal limitations of the terms NAFLD and NASH are reliance on exclusionary confounder use potentially stigmatising language. This study set out to determine if content experts patient advocates were in favor a change nomenclature and/or definition. A modified Delphi process was led by three large pan-national liver associations. consensus defined priori as supermajority (67%) vote. An independent committee external made final recommendation acronym its diagnostic criteria. total 236 panelists from 56 countries participated 4 online surveys 2 hybrid meetings. Response rates across survey rounds 87%, 83%, 78%, respectively. Seventy-four percent respondents felt that current sufficiently flawed consider name change. “nonalcoholic” “fatty” be 61% 66% respondents, Steatotic disease chosen an overarching term encompass various aetiologies steatosis. steatohepatitis important pathophysiological concept should retained. replace metabolic dysfunction–associated steatotic disease. There definition include presence at least 1 5 cardiometabolic risk factors. Those with no parameters known cause deemed have cryptogenic new category, outside pure disease, termed alcohol related/associated (MetALD), selected describe those who consume greater amounts per week (140–350 g/wk 210–420 for females males, respectively). criteria widely supported nonstigmatising, can improve awareness identification.

Язык: Английский

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American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings

Endocrine Practice, Год журнала: 2022, Номер 28(5), С. 528 - 562

Опубликована: Май 1, 2022

Язык: Английский

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A multisociety Delphi consensus statement on new fatty liver disease nomenclature

Annals of Hepatology, Год журнала: 2023, Номер 29(1), С. 101133 - 101133

Опубликована: Июнь 24, 2023

The principal limitations of the terms NAFLD and NASH are reliance on exclusionary confounder use potentially stigmatising language. This study set out to determine if content experts patient advocates were in favor a change nomenclature and/or definition. A modified Delphi process was led by three large pan-national liver associations. consensus defined priori as supermajority (67%) vote. An independent committee external made final recommendation acronym its diagnostic criteria. total 236 panelists from 56 countries participated 4 online surveys 2 hybrid meetings. Response rates across survey rounds 87%, 83%, 78%, respectively. Seventy-four percent respondents felt that current sufficiently flawed consider name change. "nonalcoholic" "fatty" be 61% 66% respondents, Steatotic disease chosen an overarching term encompass various aetiologies steatosis. steatohepatitis important pathophysiological concept should retained. replace metabolic dysfunction-associated steatotic disease. There definition include presence at least 1 5 cardiometabolic risk factors. Those with no parameters known cause deemed have cryptogenic new category, outside pure disease, termed alcohol related/associated (MetALD), selected describe those who consume greater amounts per week (140-350 g/wk 210-420 for females males, respectively). criteria widely supported nonstigmatising, can improve awareness identification.

Язык: Английский

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Advancing the global public health agenda for NAFLD: a consensus statement

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2021, Номер 19(1), С. 60 - 78

Опубликована: Окт. 27, 2021

Язык: Английский

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Non-alcoholic fatty liver disease: a multisystem disease requiring a multidisciplinary and holistic approach

˜The œLancet. Gastroenterology & hepatology, Год журнала: 2021, Номер 6(7), С. 578 - 588

Опубликована: Май 4, 2021

Язык: Английский

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Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review

Journal of Obesity & Metabolic Syndrome, Год журнала: 2023, Номер 32(3), С. 197 - 213

Опубликована: Сен. 13, 2023

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the latest term for associated with metabolic syndrome. MASLD most common cause of chronic and leading liver-related morbidity mortality. It important that all stakeholders be involved in tackling public health threat obesity obesity-related diseases, including MASLD. A simple clear assessment referral pathway using non-invasive tests essential to ensure patients severe are identified referred specialist care, while less remain primary where they best managed. While lifestyle intervention cornerstone management MASLD, cardiovascular risk must properly assessed managed because No pharmacological agent has been approved treatment but novel anti-hyperglycemic drugs appear have benefit. Medications used diabetes other conditions may need adjusted as progresses cirrhosis, especially decompensated cirrhosis. Based on tests, concepts compensated advanced clinically significant portal hypertension provide a practical approach stratifying according complications can help manage such patients. Finally, prevention sarcopenia should considered

Язык: Английский

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MAFLD: How is it different from NAFLD?

Clinical and Molecular Hepatology, Год журнала: 2022, Номер 29(Suppl), С. S17 - S31

Опубликована: Ноя. 29, 2022

“Metabolic dysfunction-associated fatty liver disease (MAFLD)” is the term suggested in 2020 to refer related systemic metabolic dysregulation. The name change from nonalcoholic (NAFLD) MAFLD comes with a simple set of criteria enable easy diagnosis at bedside for general medical community, including primary care physicians. Since introduction term, there have been key areas which superiority over traditional NAFLD terminology has demonstrated, risk and extrahepatic mortality, associations, identifying high-risk individuals. Additionally, adopted by number leading pan-national national societies due its concise diagnostic criterion, removal requirement exclude concomitant diseases, reduction stigma associated this condition. current article explores differences between diagnosis, benefit, some potential limitations, how opened up new fields research.

Язык: Английский

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Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement

˜The œLancet. Gastroenterology & hepatology, Год журнала: 2021, Номер 6(10), С. 864 - 873

Опубликована: Авг. 6, 2021

Язык: Английский

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