Metabolic Dysfunction-Associated Steatotic Liver Disease and the Cardiovascular System

Trends in Cardiovascular Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Cardiovascular-liver-metabolic health: Time to integrate liver assessment into cardiology practice?

Trends in Cardiovascular Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Clinical Variables that Predict Liver-related Events in Steatotic Liver Disease Diagnosed by a Liver Biopsy

Internal Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Objective Identifying patients at high risk of steatotic liver disease (SLD) is crucial. The fibrosis stage the most reliable marker liver-related mortality. However, noninvasive stratification methods remain controversial. Therefore, we analyzed events in who underwent a biopsy for metabolic dysfunction-associated (MASLD) or cryptogenic SLD our hospital. Methods We retrospectively reviewed clinical course to identify occurrence events. Patients This study included 146 diagnosed with through biopsy. Results Liver-related occurred 20 and were more frequent those advanced than without fibrosis. steatosis exhibit reduced progression. obesity and/or diabetes complications had lower better prognosis others. non-invasive fibrosis-4 (FIB-4) index non-alcoholic fatty (NAFLD) prognosis-related "NAFLD outcomes score (NOS)" effectively differentiated Standard laboratory data analyses revealed that total bilirubin low albumin levels factors. A multivariate analysis significant factors other NOS absence complications, FIB-4 index, level independent Conclusion score, are lean phenotypes non-diabetic should also be assessed using markers determine their risks potential outcomes.

Язык: Английский

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Lean Metabolic Dysfunction-Associated Steatotic Liver Disease

Journal of Clinical Gastroenterology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Goals: To compare outcomes of MASLD in obese and nonobese populations. Background: is emerging as one the leading causes liver failure liver-related morbidity mortality, with an increasing prevalence or lean population. The purpose this study to hepatic oncological between patients BMI nonlean BMI. Study: National Inpatient Sample (NIS) was queried from 2016 2020 for adult hospitalizations MASLD. Exclusion criteria included concurrent diagnoses viral hepatitis, alcoholic primary biliary cholangitis, hereditary hemochromatosis, autoimmune Wilson disease. Outcomes its complications were compared subgroups. Results: Patients had higher mortality rates (odds ratio: 2.10, P <0.001). cohort also odds cirrhosis, portal hypertension, SBP, ascites. subgroup gastrointestinal malignancies including esophageal cancer, gastric pancreatic colorectal cancer. Conclusions: Hospitalized ​​hepatic morbidities, malignancies. These results challenge use a predictor patients. Future studies should focus on therapeutic options their efficacies

Язык: Английский

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Representation of Sex, Race and Ethnicity in MASH Randomised Controlled Trials: A Systematic Review and Meta‐Analysis

Liver International, Год журнала: 2025, Номер 45(4)

Опубликована: Март 3, 2025

ABSTRACT Background and Aims Randomised controlled trials (RCTs) have historically underrepresented female, racial ethnic minorities across various fields. This systematic review meta‐analysis aims to examine the global distribution, reporting participation of diverse groups based on sex, race ethnicity in focused metabolic dysfunction‐associated steatohepatitis (MASH). Methods PubMed Cochrane Library databases were systematically searched for MASH RCTs (through December 13, 2024) that included any pharmacotherapy as an intervention arm. qualitatively reviewed assess their distribution populations. A proportions was performed using a generalised linear mixed model. Results One hudred nine studies identified, data from 112 19 516 participants. Of 49 countries conducted trials, 34 high‐income (69.4%). Sex, reported 111 (99.1%), 69 (61.6%) 56 (50.0%) RCTs, respectively, with improving recent years. We found no sexual gender minorities. The pooled White, Asian, Black Hispanic/Latino 54.23% (95% confidence interval [CI]: 51.31–57.12), 87.63% CI: 85.37–89.58), 4.95% 3.42–7.10), 2.27% 1.89–2.71) 31.42% 26.61–36.66), respectively. Meta‐regressions showed trend toward more White participants over time. Conclusions Although female representation has increased time, are trials. These provide overview participant call collaborative efforts among researchers, sponsors, regulators other relevant stakeholders improve diversity these

Язык: Английский

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The potential role of adipokines and hepatokines in age-related ocular diseases

Metabolism Open, Год журнала: 2025, Номер unknown, С. 100365 - 100365

Опубликована: Апрель 1, 2025

Язык: Английский

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Metabolic dysfunction-associated steatotic liver disease, metabolic alcohol-related liver disease, and incident dementia: a nationwide cohort study

BMC Gastroenterology, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 29, 2025

Язык: Английский

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Global epidemiology and implications of PNPLA3 I148M variant in MASLD: a systematic review and meta-analysis

Journal of Clinical and Experimental Hepatology, Год журнала: 2024, Номер 15(3), С. 102495 - 102495

Опубликована: Дек. 26, 2024

Язык: Английский

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СТЕАТОТИЧНА ХВОРОБА ПЕЧІНКИ: МОЖЛИВОСТІ ДІАГНОСТИКИ В ЗАГАЛЬНОЛІКАРСЬКІЙ ПРАКТИЦІ

Перспективи та інновації науки, Год журнала: 2024, Номер 8(42)

Опубликована: Сен. 2, 2024

СТЕАТОТИЧНА ХВОРОБА ПЕЧІНКИ: МОЖЛИВОСТІ ДІАГНОСТИКИ В ЗАГАЛЬНОЛІКАРСЬКІЙ ПРАКТИЦІАнотація.Питання сучасних підходів до діагностики стеатотичної хвороби печінки (СХП) є високоактуальним саме у загальнолікарській практиці.Раннє виявлення СХП важливим через її поширеність і зв'язок із серйозними ускладненнями, такими як цироз гепатоцелюлярна карцинома.Оскільки міждисциплінарною проблемою, то знання про неї необхідні повсякденній практиці не тільки гепатологам, гастроентерологам, терапевтам, а й кардіологам, ендокринологам, також лікарям загальної практикисімейної медицини, що визначає високу потребу уніфікованих стандартів з діагностики, лікування та профілактики.Так, своєчасна діагностика клінічних проявів асоційованих нею станів принципово важлива

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The dynamic patterns of metabolic-associated fatty liver disease and its severity and risk of cardiovascular disease

Hepatology International, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 23, 2024

Язык: Английский

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