Biomedicines, Год журнала: 2024, Номер 12(1), С. 201 - 201
Опубликована: Янв. 16, 2024
Globally, malignancies cause one out of six mortalities, which is a serious health problem. Cancer therapy has always been challenging, apart from major advances in immunotherapies, stem cell transplantation, targeted therapies, hormonal precision medicine, and palliative care, traditional therapies such as surgery, radiation therapy, chemotherapy. Natural products are integral to the development innovative anticancer drugs cancer research, offering scientific community possibility exploring novel natural compounds against cancers. The role like Vincristine Vinblastine thoroughly implicated management leukemia Hodgkin’s disease. computational method initial key approach drug discovery, among various approaches. This review investigates synergy between techniques, highlights their significance discovery process. transition experimental validation highlighted through vitro vivo studies, with examples betulinic acid withaferin A. path toward therapeutic applications have demonstrated clinical studies silvestrol artemisinin, preclinical investigations trials. article also addresses challenges limitations potential anti-cancer drugs. Moreover, integration deep learning artificial intelligence methods may be useful for enhancing products.
Язык: Английский
Процитировано
79Unraveling cancer progression pathways and phytochemical therapeutic strategies for its management
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Авг. 23, 2024
Cancer prevention is currently envisioned as a molecular-based approach to prevent carcinogenesis in pre-cancerous stages, i.e., dysplasia and carcinoma situ . the second-leading cause of mortality worldwide, more than 61% increase expected by 2040. A detailed exploration cancer progression pathways, including NF-kβ signaling pathway, Wnt-B catenin JAK-STAT TNF-α-mediated MAPK/mTOR apoptotic angiogenic pathways effector molecules involved development, has been discussed manuscript. Critical evaluation these through molecular approaches using phytomolecules can intersect formation its metastasis. Manipulation like NF-kβ, SOCS, β-catenin, BAX, BAK, VEGF, STAT, Bcl2, p53, caspases, CDKs played an important role inhibiting tumor growth spread. Plant-derived secondary metabolites obtained from natural sources have extensively studied for their cancer-preventing potential last few decades. Eugenol, anethole, capsaicin, sanguinarine, EGCG, 6-gingerol, resveratrol are some examples such interesting lead mentioned This work attempt put forward comprehensive understanding management herbal molecules. The different plant chronic toxicity profiling modulating development also highlighted.
Язык: Английский
Процитировано
4Enhanced Colchicine Production in Hairy Root Cultures of Gloriosa Superba L. Using Microbial Elicitors
Indian Journal of Microbiology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 3, 2025
Язык: Английский
Процитировано
0Isofraxidin Attenuates Lipopolysaccharide-Induced Cytokine Release in Mice Lung and Liver Tissues via Inhibiting Inflammation and Oxidative Stress
Biomedicines, Год журнала: 2025, Номер 13(3), С. 653 - 653
Опубликована: Март 7, 2025
Background: Isofraxidin is a hydroxylcoumarin derived from herbal Fraxinus and Eleutherococcus. It has been shown that isofraxidin antioxidant, anti-inflammatory, anti-diabetic, anti-lipidemic effects. The study aimed to examine the therapeutic effects of with without methylprednisolone ameliorate lipopolysaccharide (LPS)-induced cytokine-releasing syndrome. Methods: comprised two phases: preventive therapeutic. In all experiments involved LPS induction, single dose (5 mg/kg) was used. phase administration agents before in which 50 mg/kg methylprednisolone, 15 isofraxidin, or combination 7.5 plus 25 were given daily for 3 days induction. following after induction: once 7 days. Results: treatment ameliorates LPS-induced inflammatory oxidative stress damage mice; it reduces (IL-6, TNF-α, IL-1β, IL-8, Malondialdehyde, IFN-γ) markers. Additionally, prevented liver lung tissue induced by LPS. Conclusions: exhibited properties against lipopolysaccharide-induced cytokine storms mice via anti-inflammatory antioxidant pathways, its demonstrated synergistic outcomes.
Язык: Английский
Процитировано
0Bioprospecting of Aspergillus sp. as a promising repository for anti-cancer agents: a comprehensive bibliometric investigation
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Май 15, 2024
Cancer remains a significant global health challenge, claiming nearly 10 million lives in 2020 according to the World Health Organization. In quest for novel treatments, fungi, especially Aspergillus species, have emerged as valuable source of bioactive compounds with promising anticancer properties. This study conducts comprehensive bibliometric analysis map research landscape oncology, examining publications from 1982 present. We observed marked increase activity starting 2000, notable peak 2005 onwards. The identifies key contributors, including Mohamed GG, who has authored 15 papers 322 citations, and El-Sayed Asa, 14 264 citations. Leading countries this field include India, Egypt, China, King Saud University Cairo leading institutions. Prominent themes identified are “endophyte,” “green synthesis,” “antimicrobial,” “anti-cancer,” “biological activities,” indicating shift towards environmentally sustainable drug development. Our findings highlight considerable potential developing new therapies underscore necessity further harness these natural clinical use.
Язык: Английский
Процитировано
3Natural Product-Derived Compounds Targeting Keratinocytes and Molecular Pathways in Psoriasis Therapeutics
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 6068 - 6068
Опубликована: Май 31, 2024
Psoriasis is a chronic autoimmune inflammatory skin disorder that affects approximately 2–3% of the global population due to significant genetic predisposition. It characterized by an uncontrolled growth and differentiation keratinocytes, leading formation scaly erythematous plaques. extends beyond dermatological manifestations impact joints nails often associated with systemic disorders. Although traditional treatments provide relief, their use limited potential side effects nature disease. This review aims discuss therapeutic keratinocyte-targeting natural products in psoriasis highlight efficacy safety comparison conventional treatments. comprehensively examines pathogenesis within keratinocytes various related signaling pathways (such as JAK-STAT NF-κB) cytokines. presents molecular targets such high-mobility group box-1 (HMGB1), dual-specificity phosphatase-1 (DUSP1), aryl hydrocarbon receptor (AhR) for treating psoriasis. evaluates ability compounds luteolin, piperine, glycyrrhizin modulate psoriasis-related pathways. Finally, it offers insights into alternative sustainable treatment options fewer effects.
Язык: Английский
Процитировано
3Structure-based virtual screening methods for the identification of novel phytochemical inhibitors targeting furin protease for the management of COVID-19
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Июнь 11, 2024
The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) virus, is a highly contagious with widespread societal impact. symptoms range from cough, fever, and pneumonia to complications affecting various organs, including heart, kidneys, nervous system. Despite ongoing efforts, no effective drug has been developed stop spread of virus. Although types medications used treat bacterial viral diseases have previously employed COVID-19 patients, their side effects also observed. way SARS-CoV-2 infects human body very specific, as its spike protein plays an important role. S subunit virus cleaved proteases, such furin protein, initial step for internalization into host. Keeping this context, we attempted inhibit using phytochemicals that could produce minimal effects. For this, screened 408 natural plants having antiviral properties, against molecular docking dynamics simulations were performed. Based on binding score, top three compounds (robustaflavone, withanolide, amentoflavone) selected further validation. MM/GBSA energy calculations revealed withanolide lowest -57.2 kcal/mol followed robustaflavone amentoflavone -45.2 -39.68 kcal/mol, respectively. Additionally, ADME analysis showed drug-like properties these lead compounds. Hence, robustaflavone, amentoflavone, may therapeutic potential management targeting furin.
Язык: Английский
Процитировано
1Unearthing phytochemicals as natural inhibitors for pantothenate synthetase in Mycobacterium tuberculosis: A computational approach
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Июль 29, 2024
Pantothenate synthetase protein plays a pivotal role in the biosynthesis of coenzyme A (CoA), which is crucial molecule involved number cellular processes including metabolism fatty acid, energy production, and synthesis various biomolecules, necessary for survival Mycobacterium tuberculosis ( Mtb ). Therefore, inhibiting this could disrupt CoA synthesis, leading to impairment vital metabolic within bacterium, ultimately its growth survival. This study employed molecular docking, structure-based virtual screening, dynamics (MD) simulation identify promising phytochemical compounds targeting pantothenate (TB) treatment. Among 239 compounds, top three (rutin, sesamin, catechin gallate) were selected, with binding values ranging from −11 −10.3 kcal/mol, selected complexes showed RMSD (<3 Å) 100 ns MD time. Furthermore, mechanics generalized Born surface area (MM/GBSA) free calculations affirmed stability these phytochemicals ranges −82.24 ± 9.35 −66.83 4.5 kcal/mol. Hence, identified natural plant-derived as potential inhibitors be used inhibit TB infection humans.
Язык: Английский
Процитировано
0Natural Product-Based Treatment for Food Poisoning
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
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