The role of microRNA-185 in the pathogenesis of human diseases: A focus on cancer
Pathology - Research and Practice,
Год журнала:
2023,
Номер
249, С. 154729 - 154729
Опубликована: Авг. 16, 2023
Язык: Английский
T-2 toxin exposure induces ovarian damage in sows: lncRNA CUFF.253988.1 promotes cell apoptosis by inhibiting the SIRT3/PGC1α pathway
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
283, С. 116787 - 116787
Опубликована: Июль 26, 2024
T-2
toxin,
a
mycotoxin
found
in
foods
and
feeds,
poses
threat
to
female
reproductive
health
both
humans
animals.
LncRNA
CUFF.253988.1
(CUFF.253988.1),
highly
expressed
pigs,
has
an
undisclosed
regulatory
role.
This
study
aimed
establish
model
of
toxin-induced
ovarian
injury
sows,
vivo
vitro,
explore
the
role
potential
mechanisms
CUFF.253988.1.
The
results
showed
that
feeding
toxin-contaminated
feed
(1
mg/kg)
induced
follicle
atresia
mitochondrial
structural
damage,
accompanied
by
significant
upregulation
expression
ovaries.
Additionally,
toxin
inhibited
SIRT3/PGC1-α
pathway
associated
with
function.
Moreover,
cell
apoptosis
upregulating
Cyt
c,
Bax,
cleaved-caspase-9,
cleaved-caspase-3
proteins.
In
granulosa
AVG-16
cells
at
concentrations
10,
40
160
nM,
not
only
were
previously
mentioned
effects
observed,
but
also
decrease
membrane
potential,
ATP
content,
elevation
ROS
levels.
However,
downregulating
reversed
toxin's
inhibition
pathway,
alleviating
dysfunction
reducing
apoptosis.
Notably,
this
may
be
attributed
enrichment
mitochondria.
conclusion,
plays
pivotal
operating
through
promotion
Язык: Английский
Clinical implications of lncRNA LINC-PINT in cancer
Frontiers in Molecular Biosciences,
Год журнала:
2023,
Номер
10
Опубликована: Март 17, 2023
Long
noncoding
RNAs
(lncRNAs)
possess
the
potential
for
therapeutic
targeting
to
treat
many
disorders,
including
cancers.
Several
RNA-based
therapeutics
(ASOs
and
small
interfering
RNAs)
have
gained
FDA
approval
over
past
decade.
And
with
their
potent
effects,
lncRNA-based
are
of
emerging
significance.
One
important
lncRNA
target
is
LINC-PINT,
its
universalized
functions
relationship
famous
tumor
suppressor
gene
TP53.
Establishing
clinical
relevance,
much
like
p53,
activity
LINC-PINT
implicated
in
cancer
progression.
Moreover,
several
molecular
targets
directly
or
indirectly
used
routine
practice.
We
further
associate
immune
responses
colon
adenocarcinoma,
proposing
utility
as
a
novel
biomarker
checkpoint
inhibitors.
Collectively,
current
evidence
suggests
can
be
considered
use
diagnostic/prognostic
marker
other
diseases.
Язык: Английский
LncRNA MALAT1 signaling pathway and clinical applications in overcome on cancers metastasis
Madineh Mazarei,
Venus Shahabi Rabori,
Nazila Ghasemi
и другие.
Clinical and Experimental Medicine,
Год журнала:
2023,
Номер
23(8), С. 4457 - 4472
Опубликована: Сен. 11, 2023
Язык: Английский
The stem cell-specific long non-coding RNAs in leukemia
Clinical & Translational Oncology,
Год журнала:
2022,
Номер
25(2), С. 345 - 351
Опубликована: Сен. 27, 2022
Язык: Английский
Functional Roles of lncRNAs in Recurrent Pregnancy Loss: A Review Study.
PubMed,
Год журнала:
2023,
Номер
17(4), С. 218 - 225
Опубликована: Авг. 7, 2023
Recurrent
pregnancy
loss
(RPL)
or
recurrent
miscarriage
is
the
failure
of
before
20-24
weeks
that
influences
around
2-5%
couples.
Several
genetic,
immunological,
environmental
and
physical
factors
may
influence
RPL.
Although
various
traditional
methods
have
been
used
to
treat
post-implantation
failures,
identifying
mechanisms
underlying
RPL
improve
an
effective
treatment.
Recent
evidence
suggested
gene
expression
alterations
presented
essential
roles
in
occurrence
It
has
found
long
non-coding
RNAs
(lncRNAs)
play
functional
pathologies,
such
as
miscarriage.
lncRNAs
can
function
dynamic
scaffolds,
modulate
chromatin
function,
guide
bind
microRNAs
(miRNAs)
transcription
factors.
lncRNAs,
by
targeting
miRNAs
mRNAs,
progression
suppression
Therefore,
their
downstream
targets
might
be
a
suitable
strategy
for
diagnosis
treatment
In
this
review,
we
summarized
emerging
several
stimulation
Язык: Английский
LncRNA PRRT3-AS1 exerts oncogenic effects on nonsmall cell lung cancer by targeting microRNA-507/homeobox B5 axis
Rui Zhou,
JIANYANG XU,
LINGWEI WANG
и другие.
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics,
Год журнала:
2021,
Номер
29(6), С. 411 - 423
Опубликована: Янв. 1, 2021
Long
noncoding
RNAs
(lncRNAs)
act
as
key
regulators
controlling
complex
cellular
behaviors
in
nonsmall
cell
lung
cancer
(NSCLC).
We
investigated
the
expression
of
lncRNA
PRRT3
antisense
RNA
1
(PRRT3-AS1)
paired
samples
NSCLC
and
adjacent
normal
tissues
from
a
patient
cohort
our
hospital
using
real-time
quantitative
reverse
transcription
polymerase
chain
reaction
(qRT-PCR)
found
that
it
was
significantly
higher
tissue
than
tissue,
consistent
with
The
Cancer
Genome
Atlas
database.
Furthermore,
functional
investigation
revealed
PRRT3-AS1
depletion
inhibited
NSCLC-cell
proliferation,
colony
formation,
invasion,
migration,
whereas
its
overexpression
exerted
opposite
effects.
Moreover,
knockdown
suppressed
vivo
growth.
Investigation
downstream
mechanisms
immunoprecipitation
luciferase
reporter
assay
acted
competing
endogenous
by
adsorbing
microRNA-507
(miR-507)
enhanced
target
gene,
homeobox
B5
(HOXB5),
NSCLC.
miR-507
downregulation
or
HOXB5
upregulation
eliminated
cancer-inhibiting
effects
cells.
To
conclude,
PRRT3-AS1/miR-507/HOXB5
pathway
acts
promoter
malignant
characteristics
NSCLC,
this
newly
identified
may
be
an
effective
diagnostic,
prognostic,
therapeutic
Язык: Английский