Identification of cancer cell-intrinsic biomarkers associated with tumor progression and characterization of SFTA3 as a tumor suppressor in lung adenocarcinomas
BMC Cancer,
Год журнала:
2025,
Номер
25(1)
Опубликована: Янв. 8, 2025
Recent
advancements
in
contemporary
therapeutic
approaches
have
increased
the
survival
rates
of
lung
cancer
patients;
however,
long-term
benefits
remain
constrained,
underscoring
pressing
need
for
novel
biomarkers.
Surfactant-associated
3
(SFTA3),
a
long
non-coding
RNA
predominantly
expressed
normal
epithelial
cells,
plays
crucial
role
development.
Nevertheless,
its
function
adenocarcinoma
(LUAD)
remains
inadequately
understood.
Single-cell
sequencing
data
were
utilized
to
identify
cell-intrinsic
gene
signatures
associated
with
progression
LUAD,
and
their
roles
LUAD
comprehensively
analyzed.
Serum
samples
collected
quantify
expression
levels
SFTA3
patients.
Furthermore,
series
biological
experiments,
including
cell
viability
assays,
scratch
wound
healing
colony
formation
conducted
demonstrate
tumor-suppressive
effects
SFTA3.
was
performed
elucidate
molecular
mechanisms
underlying
cells.
We
constructed
prognostic
model
comprising
eight
genes:
ALDOA,
ATP5MD,
SERPINH1,
SFTA3,
SLK,
U2SURP,
SCGB1A1,
SCGB1A3.
The
effectively
stratified
patients
into
high-
low-risk
categories,
revealing
that
experienced
superior
clinical
outcomes,
exhibited
an
immunologically
hot
tumor
microenvironment
(TME),
had
greater
probability
responding
immunotherapy.
In
contrast,
high-risk
group
cold
TME
may
benefit
more
from
chemotherapy.
our
study
revealed
progressive
decrease
cells
correlated
advancement.
Notably,
serum
significantly
decreased
suggesting
potential
utility
liquid
biopsy
diagnosis.
Additionally,
knockdown
enhances
proliferation
migration
whereas
overexpression
inhibits
these
phenotypes.
epithelial-mesenchymal
transition
pathway
enriched
following
silencing,
impact
by
modulating
this
process.
also
identified
key
transcription
factors
epigenetic
implicated
downregulation
LUAD.
developed
robust
as
biomarker
applications
diagnosis,
prognosis,
personalized
treatment
findings
offer
new
insights
tumorigenesis
immune
evasion.
Язык: Английский
Redefining Hepatocellular Carcinoma Treatment: Nanotechnology Meets Tumor Immune Microenvironment
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 47
Опубликована: Март 13, 2025
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
lethal
malignancies
worldwide,
characterized
by
its
complex
pathogenesis
and
poor
therapeutic
outcomes.
Despite
recent
advances
in
targeted
molecular
therapies,
immune
checkpoint
inhibitors
(ICIs),
radiotherapy,
conventional
chemotherapy,
five-year
survival
rate
for
this
neoplasm
remains
dismally
low.
The
progress
nanotechnology
has
revolutionized
cancer
treatment
years.
These
provide
unprecedented
opportunities
to
overcome
current
limitations
different
modalities.
This
review
provides
a
comprehensive
analysis
how
interfaces
with
tumor
microenvironment
(TIME)
HCC
can
present
new
frontier
interventions
HCC.
We
critically
overview
latest
developments
nanoparticle-based
delivery
systems
various
drugs
also
other
antitumor
agents
like
thermal
therapy
radiotherapy.
highlight
unique
ability
nanoparticles
modulate
immunosuppressive
(TME)
enhance
efficacy.
Furthermore,
we
analyze
emerging
strategies
that
exploit
nanoformulations
biological
barriers
drug
bioavailability
treatment.
Язык: Английский
Targeting the lung tumor stroma: harnessing nanoparticles for effective therapeutic interventions
Journal of drug targeting,
Год журнала:
2024,
Номер
33(1), С. 60 - 86
Опубликована: Окт. 2, 2024
Lung
cancer
remains
an
influential
global
health
concern,
necessitating
the
development
of
innovative
therapeutic
strategies.
The
tumour
stroma,
which
is
known
as
microenvironment
(TME)
has
a
central
impact
on
expansion
and
treatment
resistance.
stroma
lung
tumours
consists
numerous
cells
molecules
that
shape
environment
for
expansion.
This
not
only
protects
tumoral
against
immune
system
attacks
but
also
enables
to
attenuate
action
antitumor
drugs.
stromal
like
cancer-associated
fibroblasts
(CAFs),
suppressive
cells,
cytotoxic
cells.
Additionally,
presence
stem
endothelial
pericytes
can
facilitate
volume
Nanoparticles
are
hopeful
tools
targeted
drug
delivery
because
their
extraordinary
properties
capacity
devastate
biological
obstacles.
review
article
provides
comprehensive
overview
contemporary
advancements
in
targeting
using
nanoparticles.
Various
nanoparticle-based
approaches,
including
passive
active
targeting,
stimuli-responsive
systems,
highlighting
potential
improve
efficiency.
role
nanotechnology
modulating
by
key
components
such
extracellular
matrix
(ECM),
hypoxia,
elements
stroma.
Язык: Английский
Decoding the complex web: Cellular and molecular interactions in the lung tumor microenvironment
Bonnie Issa,
Ayat Hussein Adhab,
Morug Salih Mahdi
и другие.
Journal of drug targeting,
Год журнала:
2024,
Номер
unknown, С. 1 - 44
Опубликована: Дек. 21, 2024
The
lung
tumor
microenvironment
(TME)
or
stroma
is
a
dynamic
space
of
numerous
cells
and
their
released
molecules.
This
complicated
web
regulates
progression
resistance
to
different
modalities.
Lung
cancer
in
conjunction
with
liberate
wide
range
factors
that
dampen
antitumor
attacks
by
innate
immunity
like
natural
killer
(NK)
also
adaptive
responses
effector
T
cells.
These
include
growth
factors,
exosomes
epigenetic
regulators,
anti-inflammatory
cytokines.
Understanding
the
intricate
interactions
between
various
elements
within
TME,
such
as
immune
stromal
can
help
provide
novel
strategies
for
better
management
treatment
malignancies.
current
article
discusses
complex
network
signaling
molecules,
which
mediate
communications
TME.
By
elucidating
these
multifaceted
interactions,
we
aim
insights
into
potential
therapeutic
targets
treatment.
Язык: Английский