A panel of three serum microRNAs as a potential diagnostic biomarker for renal cell carcinoma DOI Creative Commons

Shengjie Lin,

Xutai Li,

Zhenjian Ge

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 25, 2025

Hitherto there is no praiseworthy noninvasive methods in the early diagnosis of renal cell carcinoma (RCC). MicroRNAs (miRNAs) could be utilized as molecular markers for diverse malignancies. In this study, we aim to discern potential miRNAs screening RCC. We employed quantitative reverse transcription-polymerase chain reaction (RT-qPCR) detect expression levels candidate serum specimens 108 RCC patients and 112 health volunteers. Diagnostic values were appraised, panel was constructed by dint receiver operating characteristic curves, area under ROC curve backward stepwise logistic regression analysis. Moreover, capitalized on bioinformatics analysis exploration biological functions. The five (miR-30c-5p, miR-142-3p, miR-206, miR-223-3p, miR-200c-5p) markedly alteration subjects. A three-miRNA combining miR-30c-5p, miR-142-3p miR-206 discriminate healthy subjects satisfactorily with 0.872 (0.811-0.919, P < 0.001) AUC, 81.25% sensitivity 86.90% specificity. ATF3 MYC seem targets panel. novel miRNA-based may perform advance.

Язык: Английский

Exosomal Liquid Biopsy in Prostate Cancer: A Systematic Review of Biomarkers for Diagnosis, Prognosis, and Treatment Response DOI Open Access
Yameen Hamid, Rukhshana Dina Rabbani,

Rakkan Afsara

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 802 - 802

Опубликована: Янв. 18, 2025

Prostate cancer, a leading cause of cancer-related mortality among men, often presents challenges in accurate diagnosis and effective monitoring. This systematic review explores the potential exosomal biomolecules as noninvasive biomarkers for diagnosis, prognosis, treatment response prostate cancer. A thorough literature search through online public databases (Medline via PubMed, Scopus, Web science) using structured terms screening predefined eligibility criteria resulted 137 studies that we analyzed this review. We evaluated findings from these clinical studies, revealing load exosomes blood urine cancer patients, which includes microRNAs (miRNAs), proteins, lipids, demonstrates disease-specific changes. It also shows some markers can differentiate between malignant benign hyperplasia prostate, predict disease aggressiveness, monitor efficacy. Notably, miRNA emerged most frequently studied biomolecule, demonstrating superior diagnostic compared to traditional methods like prostate-specific antigen (PSA) testing. The analysis highlights pressing need standardised analytic approach multi-centre validate full monitoring

Язык: Английский

Процитировано

6
Exosome biosensors for detection of prostate cancer DOI
Asma Vafadar,

Sajad Alavimanesh,

Mohammad Ehsan Maddahi

и другие.

Clinica Chimica Acta, Год журнала: 2025, Номер 571, С. 120243 - 120243

Опубликована: Март 14, 2025

Язык: Английский

Процитировано

0
A panel of three serum microRNAs as a potential diagnostic biomarker for renal cell carcinoma DOI Creative Commons

Shengjie Lin,

Xutai Li,

Zhenjian Ge

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 25, 2025

Hitherto there is no praiseworthy noninvasive methods in the early diagnosis of renal cell carcinoma (RCC). MicroRNAs (miRNAs) could be utilized as molecular markers for diverse malignancies. In this study, we aim to discern potential miRNAs screening RCC. We employed quantitative reverse transcription-polymerase chain reaction (RT-qPCR) detect expression levels candidate serum specimens 108 RCC patients and 112 health volunteers. Diagnostic values were appraised, panel was constructed by dint receiver operating characteristic curves, area under ROC curve backward stepwise logistic regression analysis. Moreover, capitalized on bioinformatics analysis exploration biological functions. The five (miR-30c-5p, miR-142-3p, miR-206, miR-223-3p, miR-200c-5p) markedly alteration subjects. A three-miRNA combining miR-30c-5p, miR-142-3p miR-206 discriminate healthy subjects satisfactorily with 0.872 (0.811-0.919, P < 0.001) AUC, 81.25% sensitivity 86.90% specificity. ATF3 MYC seem targets panel. novel miRNA-based may perform advance.

Язык: Английский

Процитировано

0