Survival of Patients with Sinonasal Cancers in a Population-Based Registry, Lombardy, Italy, 2008–2023

Cancers, Год журнала: 2024, Номер 16(5), С. 896 - 896

Опубликована: Фев. 23, 2024

Sinonasal cancers (SNCs) are rare malignancies associated with occupational exposures. The aim of this study was to analyse the survival SNC patients using data from population-based registry Lombardy region (10 million people), Italy. We included epithelial cases registered in 2008–2020 and followed-up for vital status until 31 July 2023. Multivariate flexible parametric models time-dependent covariates were fitted calculate excess hazard ratios (EHRs) 95% confidence intervals (CIs) death. Based on 827 (553 males, 274 females) 514 deaths (345 169 females), 5-year observed 49% net 57%. Age had a substantial impact survival, particularly within first year (EHR, 1.35; CI, 1.12–1.51 per 10 years). Compared nasal cavity, EHR paranasal sinuses 4.70 (95% 2.96–7.47) soon after diagnosis. squamous cell carcinomas, 0.69 0.52–0.91) adenocarcinomas, 1.68 1.20–2.35) undifferentiated unspecified 1.78 1.07–2.95) neuroendocrine carcinomas. cancer site showed effects prognosis, especially month Prognosis also markedly affected by morphology. No associations found gender period

Язык: Английский

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Development of an evaluation and treatment strategy for olfactory neuroblastoma: a review of evidence from large-scale studies, including population-based and multicenter studies, and meta-analyses

Japanese Journal of Clinical Oncology, Год журнала: 2024, Номер 54(8), С. 847 - 862

Опубликована: Май 18, 2024

Olfactory neuroblastoma is a rare sinonasal malignancy arising from the olfactory epithelium that characterized by skull base involvement and modest natural history. Because of its rarity long course, identification independent prognostic factors dependent on multivariate analysis large, long-term data. In this review, we outline evidence for evaluation treatment obtained recent large-scale population-based studies, meta-analyses multicenter studies. Hyams grade currently only pathological system neuroblastoma. The modified Kadish staging Dulguerov classification are available clinical staging. results studies have confirmed Hyams, as factors. Surgery followed radiotherapy provides best overall survival recurrence-free resectable disease. question whether postoperative should be administered all cases or those at risk recurrence remains unanswered. Exclusively endoscopic resection indicated A/B without any increase in death recurrence, also C if negative surgical margin ensured. For more advanced cases, such with extensive brain infiltration, open approach indicated. Elective nodal irradiation prevents late N0 patients. Chemotherapy has failed to show benefit disease control. Current needs include development validation refined systems suitable current practice; expansion indications surgery; less invasive definitive novel systemic therapy.

Язык: Английский

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Top IHC/ISH Hacks for and Molecular Surrogates of Poorly Differentiated Sinonasal Small Round Cell Tumors

Head and Neck Pathology, Год журнала: 2024, Номер 18(1)

Опубликована: Фев. 5, 2024

Abstract Background Poorly differentiated sinonasal small round cell tumors (SRCTs) are rare and heterogeneous, posing challenges in diagnosis treatment. Methods Recent advances molecular findings diagnostic refinement have promoted better understanding management of these tumors. Results The newly defined emerging entities demonstrate diverse morphologies, specific genomic signatures, clinical behavior from conventional counterparts. In this review SRCTs, emphasis is placed on the approach with employment a pertinent panel immunohistochemistry studies and/or tests, fine-tuned to latest WHO 5 classification sinonasal/paranasal personalized Conclusion Specifically, focuses epithelial neuroectodermal derivation.

Язык: Английский

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Olfactory Neuroblastoma and Olfactory Carcinoma

Surgical pathology clinics, Год журнала: 2024, Номер 17(4), С. 637 - 652

Опубликована: Авг. 24, 2024

Язык: Английский

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Characterization of a Preclinical In Vitro Model Derived from a SMARCA4-Mutated Sinonasal Teratocarcinosarcoma

Cells, Год журнала: 2023, Номер 13(1), С. 81 - 81

Опубликована: Дек. 30, 2023

Sinonasal teratocarcinosarcoma (TCS) is a rare tumor that displays variable histology with admixtures of epithelial, mesenchymal, neuroendocrine and germ cell elements. Facing very poor prognosis, patients TCS are in need new options for treatment. Recently identified recurrent mutations SMARCA4 may serve as target modern therapies EZH1/2 CDK4/6 inhibitors. Here, we present the first vitro line TCS627, established from previously untreated primary originating ethmoid sinus invasion into brain. The cultured cells expressed immunohistochemical markers, indicating differentiation neuroepithelial, sarcomatous teratomatous components. Whole-exome sequencing revealed 99 somatic including SMARCA4, ARID2, TET2, CDKN2A, WNT7A, NOTCH3 STAG2, all both line. Focusing on mutated therapeutic target, growth inhibition assays showed strong response to inhibitor palbociclib, but much less valemetostat. In conclusion, TCS627 carries histologic genetic features characteristic valuable model basic research preclinical testing treatment patients.

Язык: Английский

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Histopathologic Diagnosis of Sinonasal Tumors: Challenges and the Importance of Establishing the Correct Diagnosis

Current Otorhinolaryngology Reports, Год журнала: 2023, Номер 11(3), С. 344 - 351

Опубликована: Июль 27, 2023

Язык: Английский

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Sox2 and βIII-Tubulin as Biomarkers of Drug Resistance in Poorly Differentiated Sinonasal Carcinomas

Journal of Personalized Medicine, Год журнала: 2023, Номер 13(10), С. 1504 - 1504

Опубликована: Окт. 18, 2023

Poorly differentiated sinonasal carcinomas (PDCs) are tumors that have a poor prognosis despite advances in classical treatment. Predictive and prognostic markers new personalized treatments could improve the oncological outcomes of patients. In this study, we analyzed SOX2 βIII-tubulin as biomarkers therapeutic impacts on these tumors. The cohort included 57 cases PDCs: 36 undifferentiated carcinoma (SNUC) cases, 13 olfactory neuroblastoma (ONB) 8 neuroendocrine (SNEC) cases. Clinical follow-up data were available for 26 Sox2 expression was detected using immunohistochemistry 6 (75%) SNEC 19 (53%) SNUC (46%) ONB absence staining correlated with higher rate recurrence (p = 0.015), especially distant recurrence. majority showed expression, strong positivity 85%, 75%, 64% SNEC, ONB, respectively. Tumors stronger demonstrated longer disease-free survival than those no or low 0.049). is common poorly has utility.

Язык: Английский

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A diagnostic approach to small round cell epithelial and neuroepithelial tumours of the sinonasal tract

Diagnostic histopathology, Год журнала: 2024, Номер 30(3), С. 179 - 187

Опубликована: Янв. 1, 2024

Язык: Английский

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Analysis of ASCL1/NEUROD1/POU2F3/YAP1 Yields Novel Insights for the Diagnosis of Olfactory Neuroblastoma and Identifies Sinonasal Tuft Cell-like Carcinoma

Modern Pathology, Год журнала: 2024, Номер unknown, С. 100674 - 100674

Опубликована: Ноя. 1, 2024

Язык: Английский

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