The Gut Microbiome and Joint Microbiome Show Alterations in Patients With Knee Osteoarthritis Versus Controls: A Systematic Review
Arthroscopy The Journal of Arthroscopic and Related Surgery,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 1, 2024
Язык: Английский
The Gut Feeling: The Role of Gut Microbiome in Orthopedics
Journal of Orthopaedic Case Reports,
Год журнала:
2025,
Номер
15(3), С. 308 - 311
Опубликована: Янв. 1, 2025
Introduction:
Advancements
in
microbiome-targeted
therapies,
including
probiotics,
prebiotics,
and
fecal
microbial
transplantation,
offer
exciting
possibilities
for
orthopedic
care.
Probiotics,
live
beneficial
microorganisms
found
fermented
foods,
such
as
yogurt,
kefir,
sauerkraut,
kimchi,
cheese,
help
maintain
a
healthy
gut
microbiome.
Prebiotics
fiber-rich
foods
onions,
garlic,
whole
grains,
nourish
these
bacteria,
supporting
their
growth
activity.
Together,
therapies
regulate
health,
promote
immune
resilience,
reduce
infection
risks,
accelerate
healing
–
key
factors
outcomes
[1,
2].
The
microbiome,
diverse
ecosystem
of
microorganisms,
plays
pivotal
role
maintaining
overall
health
[3].
Beyond
digestion,
it
influences
regulation,
inflammation
control,
musculoskeletal
well-being
[4].
Gut
significantly
impacts
outcomes,
bone
healing,
density.
An
imbalance
this
ecosystem,
known
dysbiosis,
can
compromise
recovery
increase
risks
[5].
Supporting
through
dietary
modifications,
or
prebiotics
holds
the
potential
to
enhance
patient
[6].
Orthopedic
Infections
Health:
Periprosthetic
joint
infections
fracture-related
remain
formidable
challenges
Biofilm
formation
on
implants
protect
bacteria
from
antibiotics
responses,
complicating
treatment
[7].
Dysbiosis
further
exacerbate
by
allowing
enter
bloodstream
colonize
surgical
sites
[8].
Maintaining
balanced
microbiome
body’s
defenses,
limit
bacterial
migration,
implant
longevity.
Fracture
Healing
Microbial
Influence:
Bone
repair
is
finely
regulated
process
involving
inflammation,
new
formation,
remodeling
[9].
A
an
essential
managing
moderating
promoting
cell
Disruptions
lead
excessive
hinder
ability
heal
effectively
[10].
may
improve
patients
prone
delayed
complications.
Autoimmune
Conditions
Increased
Susceptibility
Infection:
diseases,
rheumatoid
arthritis,
heighten
susceptibility
due
weakened
function
[11].
worsen
imbalance,
increasing
risk
migration
sites.
Ensuring
fortify
resilience
post-surgical
complications
with
conditions
[12].
Pain
Management
Microbiome
Modulation:
affects
pain
perception
influencing
production
neurotransmitters
that
pathways.
heightened
sensitivity,
posing
chronic
osteoarthritis
[13].
Optimizing
additional
approach
complement
traditional
management
strategies
dependency
medications.
Density
Mineral
Absorption
critical
absorbing
minerals
vital
strength
balance
impair
absorption
process,
contributing
osteoporosis
[14].
Emerging
research
suggests
specific
probiotics
mineral
absorption,
providing
supportive
therapy
improving
reducing
fracture
[15].
Post-Surgical
Recovery
Systemic
influence
extends
beyond
local
sites,
playing
systemic
following
surgery.
supports
faster
reduced
fewer
post-operative
Conversely,
imbalances
delay
[16].
Strategies
perioperative
period
rehabilitation.
Innovative
Approaches
Care:
Screening
before
surgery
could
allow
timely
interventions,
minimizing
outcomes.
While
some
experimental,
they
represent
promising
avenues
future
developments
personalized
[17].
Recent
has
revealed
alterations,
particularly
those
affecting
arginine
metabolism,
play
significant
structural
[18].
Mechanical
loading
crucial
but
its
effectiveness
often
hampered
high
variability
mechanoreceptor
activity
influenced
microbes.
Studies
have
shown
depletion
profoundly
responsiveness,
indicating
possible
pathway
therapeutic
strategies.
gut-bone
axis,
concept
gaining
attention,
connects
state
[19].
This
relationship
opens
up
changes
treat
inflammatory
arthritis.
By
understanding
researchers
are
uncovering
mechanisms
offering
hope
more
effective
treatments
future.
To
summarize
roles
practice,
table
highlights
implications
care
(Table
1).
Conclusion:
microbiome’s
infection,
presents
area
exploration.
For
surgeons
clinicians,
offers
preventive
pathways,
associated
fractures.
Future
bring
even
transforming
practices
ways
extend
approaches.
integrating
into
strategies,
health-care
providers
foster
stronger,
resilient
patients,
advancing
field
toward
holistic
Язык: Английский
The Impact of Microbiota on Musculoskeletal Injuries
Cells,
Год журнала:
2025,
Номер
14(7), С. 554 - 554
Опубликована: Апрель 7, 2025
Musculoskeletal
injuries
comprise
a
wide
range
of
physical
conditions
impacting
the
coordination
bones,
muscles,
and
joints.
Estimations
suggest
that
close
to
one-third
world’s
population
will
experience
musculoskeletal
or
non-musculoskeletal
injury
at
some
point
in
their
life.
affect
athletes,
office
workers,
industrial
older
adults,
children
every
year.
Among
individuals
over
age
65,
disproportionately
women,
limiting
ability
maintain
an
active
professional
life
engage
leisure
activities
during
retirement.
The
field
therapy
has
recently
expanded
build
understanding
complex,
non-linear
interactions
between
gut
microbiota
system.
There
is
unexpected
connection
both
pain
healing
process
following
injuries.
Understanding
mechanisms
microbiota’s
influence
on
these
could
inform
healthcare
strategies
aimed
prevention
recovery.
For
patients
who
suffer
from
are
risk
developing
injuries,
analyzing
composition
plays
crucial
role
patient
stratification,
which
can
significantly
enhance
effectiveness
treatment
strategies.
Язык: Английский
Integrative review of the gut microbiome’s role in pain management for orthopaedic conditions
World Journal of Experimental Medicine,
Год журнала:
2025,
Номер
15(2)
Опубликована: Апрель 11, 2025
The
gut
microbiome,
a
complex
ecosystem
of
microorganisms,
has
significant
role
in
modulating
pain,
particularly
within
orthopaedic
conditions.
Its
impact
on
immune
and
neurological
functions
is
underscored
by
the
gut-brain
axis,
which
influences
inflammation,
pain
perception,
systemic
responses.
This
integrative
review
examines
current
research
how
dysbiosis
associated
with
various
pathways,
notably
nociceptive
neuroinflammatory
mechanisms
linked
to
central
sensitization.
We
highlight
advancements
meta-omics
technologies,
such
as
metagenomics
metaproteomics,
deepen
our
understanding
microbiome-host
interactions
their
implications
pain.
Recent
studies
emphasize
that
gut-derived
short-chain
fatty
acids
microbial
metabolites
play
roles
neuroinflammation
nociception,
contributing
management.
Probiotics,
prebiotics,
synbiotics,
faecal
microbiome
transplants
are
explored
potential
therapeutic
strategies
alleviate
through
modulation,
offering
an
adjunct
or
alternative
opioids.
However,
variability
individual
microbiomes
poses
challenges
standardizing
these
treatments,
necessitating
further
rigorous
clinical
trials.
A
multidisciplinary
approach
combining
microbiology,
immunology,
neurology,
orthopaedics
essential
develop
innovative,
personalized
management
rooted
health,
transform
care.
Язык: Английский
Mapping knowledge landscapes and research frontiers of gastrointestinal microbiota and bone metabolism: a text-mining study
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Июль 10, 2024
Extensive
research
efforts
have
been
dedicated
to
elucidating
the
intricate
pathways
by
which
gastrointestinal
microbiota
and
their
metabolites
exert
influence
on
processes
of
bone
formation.
Nonetheless,
a
notable
gap
exists
in
literature
concerning
bibliometric
analysis
trends
at
nexus
metabolism.
Язык: Английский
Metagenomic changes in response to antibiotic treatment in severe orthopaedic trauma patients
iScience,
Год журнала:
2024,
Номер
27(9), С. 110783 - 110783
Опубликована: Авг. 23, 2024
We
investigated
changes
in
microbiome
composition
and
abundance
of
antimicrobial
resistance
(AMR)
genes
post-antibiotic
treatment
severe
trauma
patients.
Shotgun
sequencing
revealed
beta
diversity
(Bray-Curtis)
differences
between
16
hospitalized
multiple
rib
fractures
patients
10
age-
sex-matched
controls
(
Язык: Английский
Correlation of fecal microbiome dysregulation to synovial transcriptome in an equine model of obesity associated osteoarthritis
Annals of Translational Medicine,
Год журнала:
2024,
Номер
12(6), С. 112 - 112
Опубликована: Дек. 1, 2024
Osteoarthritis
(OA)
is
increasingly
thought
to
be
a
multifactorial
disease
in
which
sustained
gut
inflammation
serves
as
continued
source
of
inflammatory
mediators
driving
degenerative
processes
at
distant
sites
such
joints.
The
objective
this
study
was
use
the
equine
model
naturally
occurring
obesity
associated
OA
compare
fecal
microbiome
and
health
correlate
those
findings
differential
gene
expression
synovial
fluid
(SF)
cells,
circulating
leukocytes
cytokine
levels
(plasma,
SF)
towards
improved
understanding
interplay
between
immune
transcriptome
pathophysiology.
Feces,
peripheral
blood
mononuclear
cells
(PBMCs),
SF
were
isolated
from
healthy
skeletally
mature
horses
(n=12;
6
males,
females)
with
(n=6,
2
females,
4
males).
Horses
determined
have
via
lameness
evaluation,
response
intra-articular
(IA)
diagnostic
analgesia,
radiographic
arthroscopic
evidence.
excluded
who
had
received
medications
or
joint
injections
within
months.
Cytokine
analyses
plasma
performed
multiplex
immunoassay.
Fecal
bacterial
microbial
16s
DNA
sequencing
correlated
bulk
RNA
PBMC
using
an
Illumina
based
platform.
higher
body
condition
scores
(P=0.009).
Cytokines
elevated
[interleukin
(IL)-2,
IL-6,
IL-18,
interferon
gamma
(IFN-γ),
inducible
protein
10
(CXCL10
IP-10),
granulocyte
colony-stimulating
factor
(G-CSF)]
(IL-1β,
IL-17A,
IP-10,
G-CSF)
OA.
Microbial
principal
coordinate
analysis
(PCoA)
Bray-Curtis
dissimilarity
for
β-diversity
demonstrated
distinct
grouping
samples
versus
(P=0.003).
Faith
alpha
diversity
reduced
(P=0.02).
Analysis
composition
showed
relative
abundance
taxa
on
multiple
Specific
phyla
(Firmicutes,
Verrucomicrobia,
Tenericutes,
Fibrobacteres),
transcriptomic
differences
related
cell
structure,
extracellular
matrix,
collagen,
laminin,
migration,
motility,
These
provide
compelling
evidence
link
obesity,
dysbiosis
development
relevant
large
animal
model,
establishing
connection
here
that
provides
platform
therapeutic
interventions
targeting
can
build.
Язык: Английский