Male cuticular pheromones stimulate removal of the mating plug and promote re-mating through pC1 neurons in Drosophila females

eLife, Год журнала: 2024, Номер 13

Опубликована: Сен. 10, 2024

In birds and insects, the female uptakes sperm for a specific duration post-copulation known as ejaculate holding period (EHP) before expelling unused mating plug through ejection. this study, we found that Drosophila melanogaster females shortens EHP when incubated with males or mated shortly after first mating. This phenomenon, which termed m ale- i nduced E HP s hortening (MIES), requires Or47b+ olfactory ppk23+ gustatory neurons, activated by 2-methyltetracosane 7-tricosene, respectively. These odorants raise cAMP levels in pC1 responsible processing male courtship cues regulating receptivity. Elevated neurons reduce reinstate their responsiveness to cues, promoting re-mating faster study established MIES genetically tractable model of sexual plasticity conserved neural mechanism.

Язык: Английский

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Estrogen Receptor Alpha–Expressing Neurons in Bed Nucleus of the Stria Terminalis and Hypothalamus Encoding Aggression and Mating

eNeuro, Год журнала: 2024, Номер 11(11), С. ENEURO.0218 - 24.2024

Опубликована: Ноя. 1, 2024

Aggression and mating of male mice are strongly associated with Esr1-expressing neurons in the bed nucleus stria terminalis (BNSTpr) hypothalamus vomeronasal pathway. By projecting to downstream hypothalamus, upstream BNSTpr Esr1 gates aggression maternal behavior female mice. The medial preoptic area (MPOA) ventrolateral subdivision ventromedial (VMHvl) two subdivisions downstream. In addition receiving projections from BNSTpr, there is also a mutual projection between MPOA VMHvl. process transforming sex information into aggression, MPOA, VMHvl act as messengers information, finally producing inhibitory or excitatory projection. These different direction, but they all work together control selection that most conducive defense reproduction when encounter Here, we summarized property function connections these encode highlight importance benefits cells aggression.

Язык: Английский

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Social Experience Shapes Fighting Strategies for Reproductive Success

Опубликована: Дек. 13, 2024

Social isolation generally increases aggression but decreases mating competition, resulting in an intricate and ambiguous relationship between social experience, aggression, reproductive success. In male Drosophila , is often characterized by lunging, a frequent comparatively gentle combat behavior. Here, we establish behavioral paradigm for studying less more vigorous fighting form known as tussling. We discover that while enrichment aligning with past observations, it heightens the forceful tussling These two forms of rely on different olfactory receptor neurons, specifically Or67d lunging Or47b further identify three pairs central pC1 neurons promote Moreover, shifting from to socially enriched males facilitates better territory control success, mitigating disadvantages associated aging. findings reveal how experience shapes strategies optimize

Язык: Английский

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Social Experience Shapes Fighting Strategies for Reproductive Success

Опубликована: Дек. 13, 2024

Social isolation generally increases aggression but decreases mating competition, resulting in an intricate and ambiguous relationship between social experience, aggression, reproductive success. In male Drosophila , is often characterized by lunging, a frequent comparatively gentle combat behavior. Here, we establish behavioral paradigm for studying less more vigorous fighting form known as tussling. We discover that while enrichment aligning with past observations, it heightens the forceful tussling These two forms of rely on different olfactory receptor neurons, specifically Or67d lunging Or47b further identify three pairs central pC1 neurons promote Moreover, shifting from to socially enriched males facilitates better territory control success, mitigating disadvantages associated aging. findings reveal how experience shapes strategies optimize

Язык: Английский

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Socialization causes long-lasting behavioral changes

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 28, 2024

SUMMARY In modern human societies, social isolation acts as a negative factor for health and life quality. On the other hand, interaction also has profound effects on animal behaviors, reducing aggressiveness, feeding loss of sleep. Here, we observe that in fly Drosophila melanogaster these behavioral changes long-last even after ceased, suggesting socialization experience triggers plasticity. We find impairing long-term memory mechanisms either genetically or by anesthesia abolishes expected response to interaction. Furthermore, show increases CREB-dependent neuronal activity synaptic plasticity mushroom body, main insect center analogous mammalian hippocampus. propose awareness, understood long-lasting behavior caused with mechanistic similarities formation.

Язык: Английский

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