Exosomes-Mediated Signaling Pathway: A New Direction for Treatment of Organ Ischemia-Reperfusion Injury
Biomedicines,
Год журнала:
2024,
Номер
12(2), С. 353 - 353
Опубликована: Фев. 2, 2024
Ischemia
reperfusion
(I/R)
is
a
common
pathological
process
which
occurs
mostly
in
organs
like
the
heart,
brain,
kidney,
and
lung.
The
injury
caused
by
I/R
gradually
becomes
one
of
main
causes
fatal
diseases,
an
urgent
clinical
problem
to
be
solved.
Although
great
progress
has
been
made
therapeutic
methods,
including
surgical,
drug,
gene
therapy,
transplant
therapy
for
injury,
development
effective
methods
cure
remains
worldwide
challenge.
In
recent
years,
exosomes
have
attracted
much
attention
their
important
roles
immune
response,
antigen
presentation,
cell
migration,
differentiation,
tumor
invasion.
Meanwhile,
shown
potential
treatment
organs.
study
exosome-mediated
signaling
pathway
can
not
only
help
reveal
mechanism
behind
promoting
recovery,
but
also
provide
theoretical
basis
application
exosomes.
Here,
we
review
research
utilizing
various
from
different
types
promote
healing
focusing
on
classical
pathways
such
as
PI3K/Akt,
NF-κB,
Nrf2,
PTEN,
Wnt,
MAPK,
toll-like
receptor,
AMPK.
results
suggest
that
regulate
these
reduce
oxidative
stress,
responses,
decrease
expression
inflammatory
cytokines,
tissue
repair,
making
competitive
emerging
vector
treating
damage
Язык: Английский
Stem Cell Therapy against Ischemic Heart Disease
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3778 - 3778
Опубликована: Март 28, 2024
Ischemic
heart
disease,
which
is
one
of
the
top
killers
worldwide,
encompasses
a
series
problems
stemming
from
compromised
coronary
blood
supply
to
myocardium.
The
severity
disease
ranges
an
unstable
manifestation
ischemic
symptoms,
such
as
angina,
myocardial
death,
that
is,
immediate
life-threatening
condition
infarction.
Even
though
patients
may
survive
infarction,
resulting
ischemia-reperfusion
injury
triggers
cascade
inflammatory
reactions
and
oxidative
stress
poses
significant
threat
function
following
successful
revascularization.
Moreover,
despite
evidence
suggesting
presence
cardiac
stem
cells,
fact
cardiomyocytes
are
terminally
differentiated
cannot
significantly
regenerate
after
accounts
for
subsequent
progression
cardiomyopathy
failure,
current
advancements
in
medicine.
In
last
two
decades,
researchers
have
realized
possibility
utilizing
cell
plasticity
therapeutic
purposes.
Indeed,
cells
different
origin,
bone-marrow-
adipose-derived
mesenchymal
circulation-derived
progenitor
induced
pluripotent
all
been
shown
play
roles
disease.
addition,
discovery
stem-cell-associated
paracrine
effects
has
triggered
intense
investigations
into
actions
exosomes.
Notwithstanding
seemingly
promising
outcomes
both
experimental
clinical
studies
regarding
use
against
positive
results
fraud
or
false
data
interpretation
need
be
taken
consideration.
review
aimed
at
overviewing
application
categories
including
relevant
outcomes,
well
proposed
mechanisms
underpinning
observations.
Язык: Английский
Protective mechanism of safflower yellow injection on myocardial ischemia-reperfusion injury in rats by activating NLRP3 inflammasome
BMC Complementary Medicine and Therapies,
Год журнала:
2025,
Номер
25(1)
Опубликована: Янв. 9, 2025
This
study
intended
to
explore
whether
the
protective
effect
safflower
yellow
injection
(SYI)
on
myocardial
ischemia-reperfusion
(I/R)
injury
in
rats
mediated
of
NLRP3
inflammasome
signaling.
The
I/R
model
was
prepared
by
ligating
left
anterior
descending
coronary
artery
for
45
min
and
then
releasing
blood
flow
150
min.
96
male
Wistar
were
randomly
divided
into
sham
group,
Hebeishuang
group
(HBS),
SYI
high-dose
(I/R
+
SYI-H),
medium-dose
SYI-M)
low-dose
SYI-L).
Cell
experiments
normal
control
(NC),
Oxygen
glucose
deprivation/reoxygenation
(OGD/R),
OGD/R
Chloroquine
(OGD/R
CQ).
area
ischemia
infarction
pathological
changes
observed
Tetrazolium
method
(TTC)
HE
staining.
Myocardial
enzymes
such
as
aspartate
aminotransferase
(AST),
lactate
dehydrogenase
(LDH)
creatine
kinase
(CK)
measured
chemiluminescence
(CL)
method.
inflammatory
factors
levels
TNF-α,
IL-1β,
MCP-1,
IL-6
detected
ELISA.
expressions
inflammatory-related
proteins
(Caspase-1,
NLRP3,
TLR4,
NF-κB),
autophagosome-related
(LC3-I,
LC3-II,LC3-II/LC3-I),
apoptosis-related
(Bax,
Bcl-2,
Caspase-3,
Bcl-2/Bax)
autophagy-related
(p62/SQSTM1,
PI3K,
p-Akt,
mTOR)
Western-Blot.
morphology
cell
viability
transmission
electron
microscopy
CCK-8.
In
vivo,
compared
with
percentage
increased
tissue
arrangement
disordered
group.
addition,
activities
enzymes,
contents
factors,
proteins,
Bax
Caspase-3
increased,
while
Bcl-2
Bcl-2/Bax
decreased.
treatment
reversed
these
trends,
except
expression
proteins.
vitro,
decreased
caused
OGD/R.
However,
p62/SQSTM1
mTOR
p-AKT,
LC3-II/LC3-I
significantly
CQ
can
promote
autophagy
regulating
thereby
attenuating
response
protecting
damaged
myocardium
rats.
Язык: Английский
Evidence and perspectives on miRNA, circRNA, and lncRNA in myocardial ischemia-reperfusion injury: a bibliometric study
Journal of Cardiothoracic Surgery,
Год журнала:
2025,
Номер
20(1)
Опубликована: Янв. 15, 2025
miRNA,
circRNA,
and
lncRNA
play
crucial
roles
in
the
pathogenesis
progression
of
myocardial
ischemia-reperfusion
injury
(MI/RI).
This
study
aims
to
provide
valuable
insights
into
lncRNA,
MI/RI
from
a
bibliometric
standpoint,
with
goal
fostering
further
advancements
this
area.
The
relevant
literature
field
was
retrieved
Science
Citation
Index
Expanded
(SCI-E)
database
within
Web
Science.
"Analyze
Results"
"Citation
Report"
functions
WOS
were
utilized
compile
annual
publication
citation
counts
field.
Microsoft
Office
Excel
2019
used
organize
visualize
data.
Furthermore,
visualization
analyses
countries/regions,
institutions,
authors,
keywords,
references
conducted
using
software
CiteSpace.
A
total
858
publications
included
for
analysis
published
across
297
journals,
Molecular
Medicine
Reports
contributing
highest
number
publications.
Researchers
45
countries
participated
studies
field,
those
China
most
research
hotspots
primarily
focus
on
three
areas:
role
MI/RI,
their
potential
as
therapeutic
targets,
biomarkers.
Among
these,
circular
RNA,
therapy
target,
inflammatory
response,
cardiomyocyte
ferroptosis
are
likely
emerge
emerging
trends
overall
development
is
rise.
compilation
area
may
researchers
more
assistance
selecting
directions,
ultimately
benefiting
patients.
Язык: Английский
Involvement of Oxidative Stress and Antioxidants in Modification of Cardiac Dysfunction Due to Ischemia–Reperfusion Injury
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 340 - 340
Опубликована: Март 14, 2025
Delayed
reperfusion
of
the
ischemic
heart
(I/R)
is
known
to
impair
recovery
cardiac
function
and
produce
a
wide
variety
myocardial
defects,
including
ultrastructural
damage,
metabolic
alterations,
subcellular
Ca2+-handling
abnormalities,
activation
proteases,
changes
in
gene
expression.
Although
I/R
injury
has
been
reported
induce
formation
reactive
oxygen
species
(ROS),
inflammation,
intracellular
Ca2+
overload,
generation
oxidative
stress
considered
play
critical
role
development
dysfunction.
Increases
production
superoxide,
hydroxyl
radicals,
oxidants,
such
as
hydrogen
peroxide
hypochlorous
acid,
occur
hearts
subjected
injury.
In
fact,
mitochondria
are
major
source
excessive
ROS
due
impairment
electron
transport
system
well
xanthine
oxidase
NADPH
oxidase.
Nitric
oxide
synthase,
mainly
present
endothelium,
also
activated
injury,
leading
nitric
oxide,
which,
upon
combination
with
superoxide
generates
nitrosative
stress.
Alterations
function,
sarcolemma,
sarcoplasmic
reticulum
activities,
mitochondrial
phosphorylation,
protease
simulated
exposing
oxyradical-generating
(xanthine
plus
oxidase)
or
H2O2.
On
other
hand,
endogenous
antioxidants
dismutase,
catalase,
glutathione
peroxidase,
concentration
transcription
factor
(Nrf2),
which
modulates
expression
various
antioxidants,
depressed
hearts.
Furthermore,
pretreatment
catalase
N-acetylcysteine,
mercaptopropionylglycerine
observed
attenuate
I/R-induced
handling
Ca2+-regulatory
activities;
additionally,
it
found
depress
improve
function.
These
observations
indicate
that
intimately
involved
pathological
effects
different
alterations
Thus,
we
faced
task
developing
safe
effective
agents
for
upregulating
therapy
Язык: Английский
Research Progress on Inflammatory Response in Myocardial Ischemia-Reperfusion Injury
Advances in Clinical Medicine,
Год журнала:
2025,
Номер
15(03), С. 1944 - 1952
Опубликована: Янв. 1, 2025
Язык: Английский
Research hotspots and emerging trends of mesenchymal stem cells in cardiovascular diseases: a bibliometric-based visual analysis
Zhihang Jiang,
Jia‐Xin Yu,
Houle Zhou
и другие.
Frontiers in Cardiovascular Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Май 30, 2024
Background
Mesenchymal
stem
cells
(MSCs)
have
important
research
value
and
broad
application
prospects
in
cardiovascular
diseases
(CVDs).
However,
few
bibliometric
analyses
on
MSCs
are
available.
This
study
aims
to
provide
a
thorough
review
of
the
cooperation
influence
countries,
institutions,
authors,
journals
field
diseases,
with
provision
discoveries
latest
progress,
evolution
paths,
frontier
hotspots,
future
trends
regarding
field.
Methods
The
articles
related
were
retrieved
from
Web
Science.
was
performed
by
CiteSpace
VOSviewer,
knowledge
map
generated
based
data
obtained
articles.
Results
In
our
study,
total
4,852
publications
launched
before
August
31,
2023
accessed
through
Science
Core
Collection
(WoSCC)
database
via
searching
strategy.
Significant
fluctuations
global
observed
CVDs.
China
emerged
as
nation
largest
number
publications,
yet
shortage
high-quality
noted.
interplay
among
authors
is
visually
represented
enclosed
figures.
Importantly,
current
hotspots
elucidated.
Cluster
analysis
references
has
highlighted
considerable
interest
exosomes,
extracellular
vesicles,
microvesicles.
Besides,
keywords
revealed
strong
emphasis
myocardial
infarction,
therapy,
transplantation.
Treatment
methods-related
prominent,
while
associated
vesicles
gathered
significant
attention
long-term
perspective.
Conclusion
CVDs
become
topic
active
interest,
showcasing
its
latent
potential.
By
summarizing
identifying
discussing
advancement
CVDs,
we
aim
offer
valuable
insights
for
considering
prospects.
Язык: Английский
Research Progress of Regulatory Cell Death in Coronary Microembolization
International Journal of Medical Sciences,
Год журнала:
2024,
Номер
22(1), С. 132 - 139
Опубликована: Дек. 11, 2024
Coronary
microembolization
(CME)
is
defined
as
atherosclerotic
plaque
erosion,
spontaneous
rupture,
or
rupture
of
the
while
undergoing
interventional
therapy
resulting
in
formation
tiny
emboli
that
obstruct
coronary
microcirculatory
system.
For
percutaneous
intervention,
CME
a
major
complication,
with
periprocedural
incidence
up
to
25%.
Recent
studies
have
demonstrated
regulatory
cell
death
(RCD)
exerts
profound
influence
on
through
its
modulation
inflammatory
responses,
oxidative
stress,
death,
and
angiogenesis.
RCD,
including
apoptosis,
autophagy,
pyroptosis,
unique
class
genetically
highly
regulated
patterns
pervasive
instances
microembolization.
The
aim
this
review
summarize
currently
known
molecular
mechanisms
underlying
CME.
Further
investigations
RCD
may
unravel
new
avenues
for
prevention
treatment
Язык: Английский