The
increased
use
of
antimicrobial
compounds
such
as
copper
into
nanoparticles
changes
how
living
cells
interact
with
these
novel
materials.
nanomaterials
combats
infectious
disease
and
food
spoilage.
Fungal
infections
are
particularly
difficult
to
treat
because
the
few
druggable
targets,
Saccharomyces
cerevisiae
provides
an
insightful
model
organism
test
new
However,
characteristics
materials,
it
is
unclear
materials
if
resistance
copper-based
could
occur.
Copper
built
on
carboxymethylcellulose
microfibril
strands
(CMC-Cu)
a
promising
nanomaterial
when
imported
yeast
induce
cell
death.
α-arrestins
cargo
adaptors
that
select
which
molecules
eukaryotic
cells.
We
screened
mutants
identified
Aly2,
Rim8,
Rog3
α-arrestins,
necessary
for
internalization
CMC-Cu
nanoparticles.
Internal
reactive
oxygen
species
in
were
lower
corresponded
viability
presence
CMC-Cu.
Using
lattice
light-sheet
microscopy
live
cells,
we
determined
within
30
min
exposure.
Initially,
cytoplasmic
pH
decreased
but
returned
basal
level
90
later.
there
was
heterogeneity
response
exposure,
be
due
particles
or
differences
metabolic
states
population.
When
exposed
sublethal
concentrations
no
occurred.
Internalization
increases
potency
likely
key
preventing
fungi
from
evolving
resistance.
Strong
fluorescence
and
high
catalytic
activities
cannot
be
achieved
simultaneously
due
to
conflicts
in
free
electron
utilization,
resulting
a
lack
of
bioactivity
most
near-infrared-II
(NIR-II)
fluorophores.
To
circumvent
this
challenge,
we
developed
atomically
precise
Au22
clusters
with
strong
NIR-II
ranging
from
950
1300
nm
exhibiting
potent
enzyme-mimetic
through
atomic
engineering
create
active
Cu
single-atom
sites.
The
Au21Cu1
show
18-fold
higher
antioxidant,
90-fold
catalase-like,
3-fold
superoxide
dismutase-like
than
clusters,
negligible
loss.
Doping
single
atoms
decreases
the
bandgap
1.33
1.28
eV
by
predominant
contributions
d
states,
lost
states
effectuates
activities.
renal
clearable
can
monitor
cisplatin-induced
injury
20-
120-minute
window
visualize
it
three
dimensions
using
light-sheet
microscopy.
Furthermore,
inhibit
oxidative
stress
inflammation
cisplatin-treated
mouse
model,
particularly
kidneys
brain.
Advanced Materials,
Год журнала:
2023,
Номер
36(8)
Опубликована: Ноя. 3, 2023
Abstract
Atomically
precise
gold
nanoclusters
(NCs)
have
emerged
as
a
new
class
of
precision
materials
and
attracted
wide
interest
in
recent
years.
One
the
unique
properties
such
pertains
to
their
photoluminescence
(PL),
for
it
can
widely
span
visible
near‐infrared–I
–II
wavelengths
(NIR‐I/II),
even
beyond
1700
nm
by
manipulating
size,
structure,
composition.
The
current
research
efforts
focus
on
structure–PL
correlation
development
strategies
raising
PL
quantum
yields,
which
is
nontrivial
when
moving
from
near‐infrared
wavelengths,
especially
NIR–II
regions.
This
review
summarizes
progress
field,
including
i)
types
observed
NCs
fluorescence,
phosphorescence,
thermally
activated
delayed
well
dual
emission;
ii)
some
effective
that
are
devised
improve
yield
(QY)
NCs,
heterometal
doping,
surface
rigidification,
core
phonon
engineering,
with
double‐digit
QYs
NIR
horizons;
iii)
applications
luminescent
bioimaging,
photosensitization,
optoelectronics.
Finally,
remaining
challenges
opportunities
future
highlighted.
Nanoscale Advances,
Год журнала:
2023,
Номер
5(17), С. 4311 - 4336
Опубликована: Янв. 1, 2023
Summary
of
advances
in
synthesis
and
application
optical
ratiometric
nano-
microparticle
sensors
for
vitro
vivo
detection
pH,
oxygen,
ROS,
ions,
biomarkers
cell
microenvironment.
Dalton Transactions,
Год журнала:
2024,
Номер
53(9), С. 4214 - 4221
Опубликована: Янв. 1, 2024
Cr
3+
and
Ni
2+
codoped
Mg
0.5
Zn
Ga
2
O
4
SWIR
phosphor
exhibits
a
broadband
emission
centered
at
1304
nm
with
FWHM
of
250
nm,
achieving
near-unity
internal
quantum
efficiency
(IQE
=
97.7%)
good
thermal
stability
(70.7%@423
K).
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy,
Год журнала:
2023,
Номер
303, С. 123220 - 123220
Опубликована: Июль 30, 2023
The
properties
of
upconverting
nanoparticles
(UCNPs)
are
crucial
for
their
applications
in
biomedicine.
For
studies
organisms
and
biological
materials,
the
penetration
depth
excitation
light
is
also
essential
as
from
which
luminescence
can
be
detected.
Currently,
many
researchers
trying
to
obtain
UCNPs
with
intense
emission
under
wavelengths
transparency
windows
increase
depth.
However,
comparing
various
types
real
conditions
rare.
This
article
shows
how
deep
808,
975,
1208,
1532
nm
laser
radiation
penetrates
human
blood.
Moreover,
we
determined
thick
a
layer
blood
still
permits
observation
signal.
measured
indicated
that
near-infrared
could
pass
through
even
7.5
mm.
core/shell
NaErF4/NaYF4
materials
most
advantageous,
detectable
3.0
mm
using
laser.
We
prove
perfect
alternatives
studied
NaYF4:Yb3+,Er3+/NaYF4.
Additionally,
setup
proposed
this
potentially
decrease
reliance
on
animal
testing
initial
biomedicine
research.
Advances in business strategy and competitive advantage book series,
Год журнала:
2024,
Номер
unknown, С. 137 - 163
Опубликована: Май 17, 2024
Blockchain
is
a
distributed
database
that
shared
by
multiple
system
nodes.
The
reason
it
named
blockchain
gathers
data
in
encrypted
blocks
are
connected
to
other
sets
of
create
virtual
chain.
development
numerous
cryptocurrencies,
dApp
monetization,
smart
personal
contracts,
decentralized
finance
apps
(Defi),
and
non-fungible
tokens
(NFTs),
preceded
general
adoption
the
concept.
technology
(BT)
digital
money,
which
increases
value
every
hour
factor
bigger
than
its
previous
worth.
Even
though
blockchain's
widespread
appeal
has
been
confined
role
bitcoin
number
applications
currently
being
developed
steadily.
This
demonstrates
promise
undeniable
influence
on
business
across
many
industries.
Journal of Materials Chemistry C,
Год журнала:
2022,
Номер
11(3), С. 953 - 962
Опубликована: Дек. 11, 2022
Bi-doped
germanate
glasses
are
reported
as
all-inorganic
tunable
broadband
NIR
LED
devices
(gc-LEDs)
operating
in
both
NIR-I
and
NIR-II
regions
with
potential
applications
night
vision,
bio-imaging,
rapid
analysis
of
food
quality.
