Advances in Research on Type 2 Diabetes Mellitus Targets and Therapeutic Agents

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(17), С. 13381 - 13381

Опубликована: Авг. 29, 2023

Diabetes mellitus is a chronic multifaceted disease with multiple potential complications, the treatment of which can only delay and prolong terminal stage disease, i.e., type 2 diabetes (T2DM). The World Health Organization predicts that will be seventh leading cause death by 2030. Although many antidiabetic medicines have been successfully developed in recent years, such as GLP-1 receptor agonists SGLT-2 inhibitors, single-target drugs are gradually failing to meet therapeutic requirements owing individual variability, diversity pathogenesis, organismal resistance. Therefore, there remains need investigate pathogenesis T2DM more depth, identify targets, provide improved glycemic control solutions. This review presents an overview mechanisms action development latest agents targeting years. It also discusses emerging target-based therapies new targets emerged within last three aim our theoretical basis for further advancement targeted T2DM.

Язык: Английский

Targeting the pathogenesis and boosting the therapeutic efficacy of Parkinson's disease by advanced nanoparticles

MedComm – Biomaterials and Applications, Год журнала: 2023, Номер 2(2)

Опубликована: Июнь 1, 2023

Abstract With the aging of global population, early diagnosis and treatment neurodegenerative diseases such as Parkinson's disease (PD) have attracted considerable attention. Despite great advances achieved during past decades, PD second largest is still incurable. In clinical practice, patients are mainly treated by drugs, supplemented with deep brain stimulation or nerve nucleus destruction. The existing drugs can only relieve symptoms motor disorder, cannot stop progression PD. Compared small molecular nanoparticles exhibit multiple functions in neuroprotection neurorepair due to their tunable physical chemical properties, easy modification functionalization. Herein, we first briefly review characteristics crossing blood–brain barrier, which a primary challenge for Then, summarize pathologic mechanisms comprehensively discuss novel therapy based on diverse nanoparticles, including alleviating oxidative stress, scavenging α‐synuclein aggregates, chelating metal ions, delivering neurotrophic factors genes, transplanting stem cells. This aims highlight potential advanced

Язык: Английский

Obacunone regulates ferroptosis in ovarian cancer through the Akt/p53 pathway

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 21, 2024

Язык: Английский