Understanding the Mechanical Properties of Ultra-Deformable Liposomes Using Molecular Dynamics Simulations DOI Creative Commons
Jiaming Xu, Vyshnavi Karra, Danielle E. Large

и другие.

Опубликована: Сен. 21, 2023

Improving drug delivery efficiency to solid tumor sites is a central challenge in anti-cancer therapeutic research. Our previous experimental study (Guo et al., Nat. Commun. 2018, 9, 130) showed that soft, elastic liposomes had increased uptake and accumulation cancer cells tumors vitro vivo respectively, relative rigid particles. As first step towards understanding how liposomes’ molecular structure composition modulates their elasticity, we performed all-atom coarse-grained classical dynamics (MD) simulations of lipid bilayers formed by mixing long-tailed, unsaturated phospholipid with short-tailed saturated the same head group. The former type phospholipids considered were 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) 1,2-dipalmitoleoyl-sn-glycero-3-phosphocholine (termed here DPMPC). shorter lipids examined 1,2-diheptanoyl-sn-glycero-3-phosphocholine (DHPC), 1,2-didecanoyl-sn-glycero-3-phosphocholine (DDPC), 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC). Several concentrations surface tensions considered. results show DOPC or DPMPC systems having 25-35 mol% shortest DHPC DDPC are least rigid, area compressibility moduli KA ~10% smaller than values observed pure bilayers. These agree measurements stretching modulus lysis tension compositions. also have lower areas per lipid, form more uneven x-y interfaces water, tails both primary secondary disordered, terminal methyl groups long wriggle vertical direction, compared mixtures longer DLPC DMPC. observations confirm our hypothesis adding increasing short bilayers, alters packing thus make resulting less rigid. No formation nanodomains was noted simulations, no clear trends lateral diffusivities as concentration, varied.

Язык: Английский

Stimulus-Responsive Hydrogels for Diabetic Wound Management via Microenvironment Modulation DOI
Yang Gao, Xinxin Chen, Chaoliang He

и другие.

Biomaterials Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Diabetic wounds, a major complication of diabetes mellitus, pose significant clinical challenge. The treatment diabetic wounds requires comprehensive interventions tailored to their pathophysiological characteristics, such as recurring bacterial infection, persistent inflammation, excessive oxidative stress, and impaired angiogenesis. development stimulus-responsive hydrogel dressings offers new strategies for wound treatment. By responding various physical biochemical signals, these smart hydrogels enable real-time monitoring precise modulation the microenvironment accelerate healing. In this review, we provide an overview disease characteristics chronic introduce current approaches. We summarize cutting-edge applications signal-responsive by modulating microenvironment.

Язык: Английский

Процитировано

0
Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications DOI Creative Commons

Rixin Xie,

Wenjing Li, Kexin Shi

и другие.

Advanced NanoBiomed Research, Год журнала: 2024, Номер 4(4)

Опубликована: Фев. 15, 2024

Microneedle array systems loaded with responsive nanoparticles have received increasing attention due to the advantages of good drug stability, targeting ability, controlled release drugs, high bioavailability, painlessness, and patient compliance. Compared oral delivery, microneedle transdermal delivery eliminates need pass through gastrointestinal tract liver, reducing metabolic consumption drugs by first‐pass effect. While compared intravenous reduces discomfort does not require professional administration. However, there are few review articles on microneedles nanoparticles. Herein, current researches specific such as glucose‐responsive, pH‐responsive, enzyme‐responsive, light‐responsive, magnetic‐responsive, ultrasound‐responsive, multiresponsive, biomedical application these summarized. In addition, challenges prospects strategies briefly discussed, which will facilitate development versatile drug‐delivery strategy.

Язык: Английский

Процитировано

3
ZnO-incorporated alginate assemblies: Tunable pH-responsiveness and improved drug delivery for cancer therapy DOI

Yecheng Feng,

Wenjing Yang, Xiaojing Shi

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 255, С. 128189 - 128189

Опубликована: Ноя. 16, 2023

Язык: Английский

Процитировано

7
Understanding the Mechanical Properties of Ultradeformable Liposomes Using Molecular Dynamics Simulations DOI Creative Commons
Jiaming Xu, Vyshnavi Karra, Danielle E. Large

и другие.

The Journal of Physical Chemistry B, Год журнала: 2023, Номер 127(44), С. 9496 - 9512

Опубликована: Окт. 25, 2023

Improving drug delivery efficiency to solid tumor sites is a central challenge in anticancer therapeutic research. Our previous experimental study (Guo et al., Nat. Commun.2018, 9, 130) showed that soft, elastic liposomes had increased uptake and accumulation cancer cells tumors vitro vivo respectively, relative rigid particles. As first step toward understanding how liposomes' molecular structure composition modulates their elasticity, we performed all-atom coarse-grained classical dynamics (MD) simulations of lipid bilayers formed by mixing long-tailed unsaturated phospholipid with short-tailed saturated the same headgroup. The former types phospholipids considered were 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) 1,2-dipalmitoleoyl-sn-glycero-3-phosphocholine (termed here DPMPC). shorter lipids examined 1,2-diheptanoyl-sn-glycero-3-phosphocholine (DHPC), 1,2-didecanoyl-sn-glycero-3-phosphocholine (DDPC), 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC). Several concentrations surface tensions considered. results show DOPC or DPMPC systems having 25-35 mol % shortest DHPC DDPC are least rigid, area compressibility moduli KA ∼10% smaller than values observed pure bilayers. These agree measurements stretching modulus lysis tension compositions. mixed also have lower areas per form more uneven x-y interfaces water, tails both primary secondary disordered, terminal methyl groups long wriggle vertical direction, compared mixtures longer DLPC DMPC. observations confirm our hypothesis adding increasing short alters packing thus makes resulting less rigid. No formation nanodomains was noted simulations, no clear trends lateral diffusivities as concentration, type lipid, varied.

Язык: Английский

Процитировано

6
An Overview of Nanotherapeutic Drug Delivery Options for the Management of Glioblastoma DOI Creative Commons
William Pentz, Vincenzo J. Pizzuti,

Matthew Halbert

и другие.

Journal of Nanotheranostics, Год журнала: 2023, Номер 4(3), С. 323 - 345

Опубликована: Авг. 1, 2023

Glioblastoma is the most common primary, malignant brain tumor that remains uniformly lethal in nearly all cases as a result of extreme cellular heterogeneity, treatment resistance, and recurrence. A major hurdle therapeutic delivery to tumors blood–brain barrier (BBB), which tightly regulated vascular between parenchyma systemic circulation prevents distribution otherwise beneficial chemotherapeutics central nervous system tumors. To overcome obstacle drug beyond BBB, nanoparticle formulations have come forefront, having demonstrated success preclinical observations, but not translated well into clinical setting. In summary, this review article discusses challenges for caused by explores benefits delivery, describes characteristics these possess make them attractive strategies, provides examples implement nanoparticles within glioma regimens. Additionally, we explore pitfalls associated with translation conclude remarks geared toward overcoming issues.

Язык: Английский

Процитировано

5
Formulation, Characterization and In Vitro Evaluation of Mesalamine and Bifidobacterium bifidum Loaded Hydrogel Beads in Capsule System for Colon Targeted Delivery DOI
Jagtar Singh, Mohit Sharma, Harmeet Singh

и другие.

AAPS PharmSciTech, Год журнала: 2024, Номер 25(3)

Опубликована: Март 14, 2024

Язык: Английский

Процитировано

1
Simple strategy of the use of pharmaceutically functionalized ionic liquids in a new generation of polymer nanocarriers for combined delivery of ionic p-Aminosalicylate and ampicillin DOI
Shadi Keihankhadiv, Dorota Neugebauer

International Journal of Pharmaceutics, Год журнала: 2024, Номер 662, С. 124483 - 124483

Опубликована: Июль 18, 2024

Язык: Английский

Процитировано

1
Self-Luminescent Drug Delivery Vehicle: Synthesis, Self-Assembly Behavior, Cysteine-Responsive Property, and Application in the Visualization of Drug Release DOI
Danyu Xia,

Yujie Cheng,

Bicong Liang

и другие.

Langmuir, Год журнала: 2023, Номер 39(41), С. 14680 - 14687

Опубликована: Окт. 4, 2023

Targeted drug delivery systems have gained great attention from the chemistry and biomedical fields in recent years due to minimized harm normal cells. When designing targeted systems, property of harmlessness cells tracking ability whole process are quite crucial. These two characters can be brought into related by applying a carrier that is self-luminescent its release induced microenvironment cancer Therefore, design synthesis vehicles significant for fabrication target systems. Herein, we synthesized cysteine-responsive fluorescent molecule, maleic acid-modified tetraphenylethylene derivative (MATPE), facile method. In addition, system with self-luminescence cysteine-responsiveness based on self-assembly MATPE was fabricated. this system, cysteine both played dual roles as probe/drug emission-enhanced inducement/drug-release stimulus. The drug-release successfully realized visualized, exhibiting potential field theranostics.

Язык: Английский

Процитировано

2
Understanding the Mechanical Properties of Ultra-Deformable Liposomes Using Molecular Dynamics Simulations DOI Creative Commons
Jiaming Xu, Vyshnavi Karra, Danielle E. Large

и другие.

Опубликована: Сен. 21, 2023

Improving drug delivery efficiency to solid tumor sites is a central challenge in anti-cancer therapeutic research. Our previous experimental study (Guo et al., Nat. Commun. 2018, 9, 130) showed that soft, elastic liposomes had increased uptake and accumulation cancer cells tumors vitro vivo respectively, relative rigid particles. As first step towards understanding how liposomes’ molecular structure composition modulates their elasticity, we performed all-atom coarse-grained classical dynamics (MD) simulations of lipid bilayers formed by mixing long-tailed, unsaturated phospholipid with short-tailed saturated the same head group. The former type phospholipids considered were 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) 1,2-dipalmitoleoyl-sn-glycero-3-phosphocholine (termed here DPMPC). shorter lipids examined 1,2-diheptanoyl-sn-glycero-3-phosphocholine (DHPC), 1,2-didecanoyl-sn-glycero-3-phosphocholine (DDPC), 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC). Several concentrations surface tensions considered. results show DOPC or DPMPC systems having 25-35 mol% shortest DHPC DDPC are least rigid, area compressibility moduli KA ~10% smaller than values observed pure bilayers. These agree measurements stretching modulus lysis tension compositions. also have lower areas per lipid, form more uneven x-y interfaces water, tails both primary secondary disordered, terminal methyl groups long wriggle vertical direction, compared mixtures longer DLPC DMPC. observations confirm our hypothesis adding increasing short bilayers, alters packing thus make resulting less rigid. No formation nanodomains was noted simulations, no clear trends lateral diffusivities as concentration, varied.

Язык: Английский

Процитировано

1