Science China Materials, Год журнала: 2024, Номер 67(11), С. 3742 - 3752
Опубликована: Сен. 25, 2024
Язык: Английский
Advanced Functional Materials, Год журнала: 2024, Номер 34(44)
Опубликована: Июль 16, 2024
Abstract Despite its effectiveness in exterminating tumor cells, ferroptosis is seriously hampered by the high expression of antioxidant glutathione (GSH) and inadequacy endogenous H 2 O tumors. Herein, metal‐phenolic nanoformulations (FNCP NFs) composed sonosensitizer Chlorin e6 (Ce6), phenolic GSH consumer naphthazarin, Fe 3+ , followed modification PEG2000, are strategically designed fabricated for ultrasound‐boosted cells through triple regulatory pathways. The carrier‐free FNCP NFs can rapidly dissociate under microenvironment response with assistance ultrasound, releasing 2+ Ce6, naphthazarin. Ce6 capable producing singlet oxygen ( 1 ) hydroxyl radicals · OH) ultrasound‐activated sonodynamic therapy Fenton reaction‐mediated chemodynamic (CDT), respectively, which not only induce apoptotic cell death but also lead to effective accumulation lipid peroxidation (LPO), resulting ferroptosis. Meanwhile, released naphthazarin self‐cycling valence alternations /Fe promote significant decrease intracellular contents, further inducing inactivation peroxidase 4 (GPX4) up‐regulation LPO levels, eventually realizing synergistically enhanced This facile feasible design versatile offers a new strategy effectively improving efficiency multimodal cancer therapies.
Язык: Английский
Процитировано
15
Materials Today Bio, Год журнала: 2025, Номер 30, С. 101447 - 101447
Опубликована: Янв. 5, 2025
Chemodynamic therapy (CDT) is an emerging antitumor strategy utilizing iron-initiated Fenton reaction to destroy tumor cells by converting endogenous H2O2 into highly toxic hydroxyl radical (OH). However, the intratumoral overexpressed glutathione (GSH) and deficient acid greatly reduce CDT efficacy because of OH scavenging decreased production efficiency. Even worse, various physiological barriers, especially in glioma, further put brakes on targeted delivery agents. Herein, exploring thiol potential 5,5'-dithiobis-2-nitrobenzoic (DTNB), we have constructed a tailored biomimetic nanoreactor improve glioma through synchronous GSH exhaustion acidity elevation. The was fabricated employing DTNB drive nano-assembly BSA molecules, followed loading carrier onto cell surface neutrophils via disulfide-thiol exchange. Upon sensing inflammatory signal, hijacked efficiently targets site, which then dually depletes disulfide bond stabilizing nanostructure following liberated Fe (III). In particular, simultaneously released can not only consume residual GSH, but also produce 5-thio-2-nitrobenzoic (TNB) promptly, resulting accelerated reaction. Through vitro vivo experiments, demonstrate exhaustive regulation chemistry could potentially serve as novel for glioma.
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 19, 2025
Abstract Transition metals especially Fe‐based catalysts representing an emerging type of enzyme‐mimicking materials are great interest in biosensing and therapy fields. However, the poor affinity toward H 2 O limits their catalytic activity while high‐precise controllable regulation engineering nanozymes remains a challenge. Herein, facile approach is presented to fabricate FeCu/hemin aerogel with self‐supported, hierarchically porous network structures through second metal center surface ligand engineering, achieving sequential ‐affinity amplification. Excitingly, for exhibits 14.03‐fold enhancement than that Fe particle, accompanied 5.88‐fold efficiency ( K cat / m ) increase FeCu. Mechanism studies suggest Cu hemin modifications upshift d ‐band from −0.49 −0.17 eV promote electron transfer process, thus facilitating dissociation . Importantly, allow highly sensitive detection norfloxacin low limit 72 n Notably, it shows remarkable inhibition on bacterial growth vitro vivo no apparent side effects. Therefore, this work not only sheds light rational design active stable properties, but also offers new prospects tuning boost enzyme‐mimic activity.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160576 - 160576
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Nano Letters, Год журнала: 2025, Номер unknown
Опубликована: Апрель 22, 2025
Nanophotoresponsive technology has emerged as a promising way to enhance plant photosynthesis, but it faces limitations in light absorption and electron transfer efficiency. This study presents photoresponsive nanosystem, LDNPs@Fe,Cu-CDs, combining lanthanide-doped nanoparticles (LDNPs) Fe/Cu dual single-atom-doped carbon dots (CDs). Fabricated via hydrothermal synthesis, the nanosystem can regulate growth through absorption, photothermal effects, photoelectron generation, photocatalysis. Using simple surface spraying method, LDNPs@Fe,Cu-CDs be absorbed by leaves transported into N. benthamiana. harvest both near-infrared ultraviolet for photosynthesis promote photosynthetic chain 33.2%. The increased chlorophyll levels 28.4% enhanced 67.5%. Additionally, alleviate of reactive oxygen species cold environments, improving growth. wet dry weight benthamiana were 57.7% 50.5%, respectively. show great potential "nanophotofertilizer" agricultural applications.
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101889 - 101889
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Nano Letters, Год журнала: 2024, Номер 24(37), С. 11738 - 11746
Опубликована: Сен. 4, 2024
Fluoride-based lanthanide-doped nanoparticles (LDNPs) featuring second near-infrared (NIR-II, 1000-1700 nm) downconversion emission for bioimaging have attracted extensive attention. However, conventional LDNPs cannot be degraded and eliminated from organisms because of an inert lattice, which obstructs applications. Herein, the core-shell Na
Язык: Английский
Процитировано
2
Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110501 - 110501
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
1
Science China Materials, Год журнала: 2024, Номер 67(11), С. 3742 - 3752
Опубликована: Сен. 25, 2024
Язык: Английский
Процитировано
1