Methods in molecular biology, Год журнала: 2023, Номер unknown, С. 133 - 153
Опубликована: Дек. 8, 2023
Язык: Английский
Vaccines, Год журнала: 2022, Номер 10(7), С. 1068 - 1068
Опубликована: Июль 3, 2022
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), is associated with a robust immune response. development of systemic inflammation leads to hyperinflammatory state due cytokine release during COVID-19. emergence many new SARS-CoV-2 variants across the world deteriorates protective antiviral immunity induced after infection or vaccination. innate response crucial for determining fate COVID-19 symptomatology. T cell-mediated main factor response; moreover, initiates rapid B-cell In this paper, we present current knowledge on and We discuss mechanisms various types vaccines (nucleoside-modified, adenovirus-vectored, inactivated virus recombinant protein adjuvanted formulations). This includes specific aspects vaccination in selected patient populations altered activity (the elderly, children, pregnant women, solid organ transplant recipients, patients rheumatic diseases malignancies). also diagnostic research tools available study anti-SARS-CoV-2 cellular humoral responses.
Язык: Английский
Процитировано
21
The Journal of Microbiology, Год журнала: 2022, Номер 60(3), С. 235 - 237
Опубликована: Март 1, 2022
Язык: Английский
Процитировано
19
PeerJ Computer Science, Год журнала: 2024, Номер 10, С. e2062 - e2062
Опубликована: Июль 30, 2024
The SARS-CoV-2 virus, which induces an acute respiratory illness commonly referred to as COVID-19, had been designated a pandemic by the World Health Organization due its highly infectious nature and associated public health risks it poses globally. Identifying critical factors for predicting mortality is essential improving patient therapy. Unlike other data types, such computed tomography scans, x-radiation, ultrasounds, basic blood test results are widely accessible can aid in mortality. present research advocates utilization of machine learning (ML) methodologies likelihood disease like COVID-19 leveraging data. Age, LDH (lactate dehydrogenase), lymphocytes, neutrophils, hs-CRP (high-sensitivity C-reactive protein) five extremely potent characteristics that, when combined, accurately predict 96% cases. By combining XGBoost feature importance with neural network classification, optimal approach exceptional accuracy from disease, along achieving precision rate 90% up 16 days before event. studies suggested model’s excellent predictive performance practicality were confirmed through testing three instances that depended on outcome. carefully analyzing identifying patterns these significant biomarkers insightful information has obtained simple application. This study offers potential remedies could accelerate decision-making targeted medical treatments within healthcare systems, utilizing timely, accurate, reliable method.
Язык: Английский
Процитировано
2
Vaccines, Год журнала: 2023, Номер 11(3), С. 539 - 539
Опубликована: Фев. 24, 2023
Messenger ribonucleic acid (RNA) vaccines are mainly used as SARS-CoV-2 vaccines. Despite several issues concerning storage, stability, effective period, and side effects, viral vector widely for the prevention treatment of various diseases. Recently, vector-encapsulated extracellular vesicles (EVs) have been suggested useful tools, owing to their safety ability escape from neutral antibodies. Herein, we summarize possible cellular mechanisms underlying EV-based
Язык: Английский
Процитировано
3
Human Vaccines & Immunotherapeutics, Год журнала: 2023, Номер 19(1)
Опубликована: Янв. 2, 2023
Patients received kidney transplantation (KTR) have a low seroconversion rate after vaccination. Our objective was to compare the rates and adverse effects of additional different vaccinations in KTR patients existing studies. Databases such as PubMed, Cochrane Library, Web Science, Embase, ClinicalTrials.gov others. Three high-quality RCT were included showed no statistical difference between two vaccines (RR = 0.93[0.76,1.13]). There sexes, for men 0.93[0.69,1.25]) women 0.91[0.62,1.33]). Among there statistically significant fever 1.06[0.44,2.57]), while injection site pain 1.14[1.18,1.84]). with who vaccines. injected viral vector vaccine less painful than those mRNA vaccine.
Язык: Английский
Процитировано
2
Journal of microbiology epidemiology immunobiology, Год журнала: 2024, Номер 101(1), С. 36 - 51
Опубликована: Март 9, 2024
Introduction. Despite the end of COVID-19 pandemic, problem vaccine prevention this disease appears highly relevant. The emergence and widespread distribution Omicron SARS-CoV-2 variant concern (VOC) its sublineages has dramatically reduced efficacy vaccination. possible approach to solving is develop a nasal live attenuated capable activating humoral, mucosal, cell-mediated immunity, providing prolonged immune response cross-protection against different VOCs. aim study was determine immunization with cold-adapted Wuhan-like D-D2 strain homologous heterologous challenges. Materials methods. conducted on an animal model coronavirus pneumonia in golden Syrian hamsters. assessed by comparing dynamics weight, viral load organs histopathological changes lungs immunized unimmunized animals. Results. Single intranasal hamsters showed high immunogenicity: seroconversion evident all provides effective protection development productive infection when challenged both ancestral virus strains related Delta (AY.122) (sublineages BA.1.1 BA.5.2) variants. Conclusion. attenuation promising strategy for vaccine.
Язык: Английский
Процитировано
0
Methods in molecular biology, Год журнала: 2023, Номер unknown, С. 133 - 153
Опубликована: Дек. 8, 2023
Язык: Английский
Процитировано
0