Do morphogenetic switching and intraspecies variation enhance virulence of Candida auris? DOI Creative Commons
Trinh Phan-Canh, Karl Kuchler

PLoS Pathogens, Год журнала: 2024, Номер 20(10), С. e1012559 - e1012559

Опубликована: Окт. 15, 2024

Intraspecies variations that affect pathogenicity and antifungal resistance traits pose a serious obstacle to efficient therapy of Candida auris infections. Recent reports indicate mutations determine drug susceptibility virulence. However, alone cannot fully explain bewildering variety phenotypes in clinical isolates from known C. clades, suggesting an unprecedented complexity underlying virulence resistance. Hence, we wish discuss how phenotypic plasticity promotes morphogenetic switching contributes intraspecies the human fungal pathogen auris. Further, will also events can impact progress molecular mycology research aims find better treatments for Finally, present our opinion as most relevant questions be addressed when trying understand pathophysiology

Язык: Английский

Fungi Associated with Sand and Plants from Marine Coastlines: Potential Relevance for Human Health DOI Open Access
Marina Carrasco-Acosta, Pilar García‐Jiménez

Advances in Microbiology, Год журнала: 2024, Номер 14(06), С. 303 - 316

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0

Coccidioidomycosis in Immunocompromised at a Non-Endemic Referral Center in Mexico DOI Creative Commons
Carla Marina Román-Montes,

Lisset Seoane-Hernández,

Rommel Flores-Miranda

и другие.

Journal of Fungi, Год журнала: 2024, Номер 10(6), С. 429 - 429

Опубликована: Июнь 18, 2024

The incidence and distribution of coccidioidomycosis are increasing. Information scarcity is evident in Mexico, particularly non-endemic zones specific populations. We compared the treatment outcomes for patients with isolated pulmonary infections those disseminated coccidioidomycosis, including mortality rates within six weeks diagnosis. Of 31 CM cases, 71% were male 55% disseminated. For 42% patients, there was no evidence having lived or visited an endemic region. All had at least one comorbidity, 58% pharmacologic immunosuppressants. general rate 30%; without differences between localized disease. In our research, we describe a high frequency disease risk factors non-significant mortality. Exposure to regions not found considerable number subjects. consider diverse reasons why this may be, such as climate change migration.

Язык: Английский

Процитировано

0

Strongyloidiasis co-occurrence with tuberculosis and aspergillosis in immunocompromised patients: a global scoping review DOI Creative Commons

Christian Ide,

David E. Elem,

Thelma E. Bassey

и другие.

The Egyptian Journal of Internal Medicine, Год журнала: 2024, Номер 36(1)

Опубликована: Авг. 22, 2024

Abstract Reports on cases of strongyloidiasis and tuberculosis or aspergillosis coinfection are fragmented in the literature no large-scale reviews describing its occurrence across globe. We identified a total 230 amongst 2376 participants with disease from eight epidemiological surveys conducted Ethiopia ( n = 4, 50%); Tanzania 3, 37.5%) Malaysia 1, 12.5%). Clinical outcomes these studies were not stated as they largely descriptive. In addition, there ten individual case reports coinfection. Of ten, four USA (40%), two each India (20%) Japan (20%), one UK (10%) Argentina (10%). six had favourable outcomes, fatal unclear remainder. Ten identified, five reported (50%), Netherlands (10%), China Iran Colombia Italy Five outcomes. Fatal associated steroid therapy 3), decline for treatment 1), delayed diagnosis 2) presentation 1). Our findings suggest significant proportion individuals living also affected strongyloidiasis, especially sub-Saharan Africa. However, more required to ascertain burden few other highly burdened regions. role attending clinician is critical reduce morbidities coexistence clinical entities number documented fatal.

Язык: Английский

Процитировано

0

Do morphogenetic switching and intraspecies variation enhance virulence of Candida auris? DOI Creative Commons
Trinh Phan-Canh, Karl Kuchler

PLoS Pathogens, Год журнала: 2024, Номер 20(10), С. e1012559 - e1012559

Опубликована: Окт. 15, 2024

Intraspecies variations that affect pathogenicity and antifungal resistance traits pose a serious obstacle to efficient therapy of Candida auris infections. Recent reports indicate mutations determine drug susceptibility virulence. However, alone cannot fully explain bewildering variety phenotypes in clinical isolates from known C. clades, suggesting an unprecedented complexity underlying virulence resistance. Hence, we wish discuss how phenotypic plasticity promotes morphogenetic switching contributes intraspecies the human fungal pathogen auris. Further, will also events can impact progress molecular mycology research aims find better treatments for Finally, present our opinion as most relevant questions be addressed when trying understand pathophysiology

Язык: Английский

Процитировано

0