The interplay of exercise and green tea: a new road in cancer therapy
Cancer Cell International,
Год журнала:
2025,
Номер
25(1)
Опубликована: Янв. 7, 2025
Exercise
is
one
of
the
most
important
activities
for
every
individual
due
to
its
proven
health
beneficials.
Several
investigations
have
highlighted
advantageous
impacts
aerobic
exercise,
largely
attributed
capacity
enhance
body's
capability
defend
against
threats
oxidative
stress.
The
information
currently
accessible
suggests
that
adding
regular
exercise
a
daily
routine
greatly
decreases
chances
developing
serious
cancer
and
passing
away.
An
unevenness
in
levels
free
radicals
antioxidant
defenses,
made
up
enzyme
non-enzyme
antioxidants,
results
pressure.
Generally,
an
imbalance
stress
triggers
creation
harmful
reactive
oxygen
or
nitrogen
compounds,
causing
development
progression
numerous
ailments,
including
cancer.
equilibrium
between
pro-oxidant
substances
direct
indicator
this
imbalance.
Green
tea
derivatives
are
rich
sources
bioactive
such
as
flavonoids
polyphenols
which
possess
abilities.
Moreover,
modulation
epigenetic
targets
well
inflammatory
pathways
ERK1/2
NF-κB
other
proposed
mechanisms
activity.
Recent
studies
demonstrate
promise
green
antioxidant,
showing
ability
decrease
likelihood
by
impacting
actions
like
cell
growth,
blood
vessel
formation,
spread
cells.
This
summary
will
concentrate
on
complex
network
different
related
physical
activity
consumption
tea.
In
particular,
focus
research
be
examining
how
contributes
investigating
potential
properties
tea,
interconnected
relationship
treatment
Elucidation
these
would
help
scientists
better
therapeutic
further
increase
current
anticancer
agents
efficiency.
Язык: Английский
Comparative Assessment of Phytochemical Content and Antioxidant Activities in Different Parts of Pyrus ussuriensis Cultivars
Horticulturae,
Год журнала:
2025,
Номер
11(2), С. 184 - 184
Опубликована: Фев. 8, 2025
Pyrus
ussuriensis,
also
known
as
Ussurian
pear,
is
a
deciduous
tree
from
the
Rosaceae
family.
This
study
examined
phytochemical
profiles
and
antioxidant
activities
of
different
parts
(1-year-old
stem,
2-year-old
leaves)
ussuriensis
Maxim.
P.
var.
ovoidea.
The
analysis
included
measurements
total
polyphenol
content
(TPC),
flavonoid
(TFC),
evaluations
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic
acid)
(ABTS+)
radical
scavenging
activities.
Quantitative
analyses
were
conducted
using
liquid
chromatography–tandem
mass
spectrometry
(LC-MS/MS)
high-performance
chromatography
(HPLC/UV).
with
one-way
ANOVA
indicated
significant
differences
in
TPC
TFC
across
tissues,
stems
exhibiting
highest
leaves
showing
both
Among
structures,
exhibited
TPC,
whereas
ovoidea
displayed
stronger
activity
than
ussuriensis.
LC-MS/MS
detected
18
phytochemicals,
chlorogenic
acid
being
most
abundant,
especially
leaf
extracts,
confirmed
HPLC/UV
analyses.
cultivar-based
comparison
highlights
tissue-specific
distribution
bioactive
compounds,
primarily
contributing
to
high
polyphenolic
content.
Collectively,
these
findings
provide
valuable
insights
into
rich
diversity
potential
cultivars,
highlighting
their
versatility
various
fields.
Язык: Английский
Polyphenol-Based Prevention and Treatment of Cancer Through Epigenetic and Combinatorial Mechanisms
Nutrients,
Год журнала:
2025,
Номер
17(4), С. 616 - 616
Опубликована: Фев. 8, 2025
Polyphenols
have
been
shown
to
be
utilized
as
an
effective
treatment
for
cancer
by
acting
a
DNMT
or
HDAC
inhibitor,
reducing
inflammatory
processes,
and
causing
cell
cycle
arrest.
While
there
many
studies
demonstrating
the
anti-cancerous
potential
of
individual
polyphenols,
are
limited
on
combinatorial
effects
polyphenols.
This
review
focuses
how
combinations
different
polyphenols
can
used
chemotherapeutic
option
patients.
Specifically,
we
examine
three
commonly
polyphenols:
curcumin,
resveratrol,
epigallocatechin
gallate.
These
induce
apoptosis,
prevent
colony
formation
migration,
increase
tumor
suppression,
reduce
viability
angiogenesis,
create
several
epigenetic
modifications.
In
addition,
these
were
synergistic
additive.
Thus,
findings
suggest
that
using
at
appropriate
concentrations
better
more
efficacious
against
compared
individually.
Язык: Английский
Ellagic Acid Displays a Protective Effect on Red Blood Cell Membrane During Aging in Humans
Indian Journal of Clinical Biochemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 22, 2024
Язык: Английский
Multifunctional approach with LHRH-mediated PLGA nanoconjugate for site-specific codelivery of curcumin and BCL2 siRNA in mice lung cancer
Future Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
10(1)
Опубликована: Ноя. 20, 2024
Abstract
Background
Lung
cancer
remains
a
leading
type,
but
current
chemotherapy
is
limited
by
issues
including
poor
drug
delivery,
toxicity,
and
resistance.
To
address
these
challenges,
we
developed
novel
PLGA-PEG-LHRH
(PPL)
nanoconjugate
system
for
improved
delivery.
Curcumin,
known
its
anticancer
P-gp
inhibition
properties,
was
co-loaded
with
bcl2siRNA
(bclsR)
to
inhibit
the
bcl2
protein,
thus
overcoming
both
resistance
mechanisms.
Results
The
PPL
conjugate
successfully
synthesized
characterized
using
FTIR,
1
H
NMR,
XRD,
XPS
BCA
assay.
Curcumin
bclsR-loaded
PLGA
nanoemulsions
were
prepared
double
emulsion
solvent
evaporation
method
characterized.
optimized
had
size
of
179
±
16
nm,
favorable
zeta
potential,
high
entrapment,
confirmed
via
TEM.
Controlled
release
studies
indicated
83%
within
24
h.
In
vitro
revealed
significant
cytotoxicity
against
A549
lung
cells,
showing
IC50
8.24
µg/mL
compared
21.26
plain
curcumin.
Enhanced
cellular
uptake
effective
targeting
cells
observed.
Molecular
analyses
demonstrated
downregulation
MDR1
Bcl2
RNA
protein
expression,
highlighting
nanoconjugates'
ability
suppress
Pharmacokinetic
in
Wistar
rats
showed
superior
plasma
concentrations,
half-life,
AUC
versus
pure
suspension.
Biodistribution
increased
accumulation
lungs.
vivo
efficacy
Balb/c
mice
higher
tumor
ratios
CUR-siRNA
NPs
(66.89%)
CUR-PPL
(59.84%)
which
further
TNFα
p53
levels
blood.
Histopathological
good
healing
NP-
NP-treated
Conclusion
From
study,
it
may
be
concluded
that
system,
loaded
curcumin
bcsR,
can
potentially
effective,
multifunctional
targeted
approach
therapy.
Graphical
Язык: Английский