The Janus Face of Oxidative Stress and Hydrogen Sulfide: Insights into Neurodegenerative Disease Pathogenesis DOI Creative Commons
Constantin Munteanu, Anca‐Irina Galaction, Gelu Onose

и другие.

Antioxidants, Год журнала: 2025, Номер 14(3), С. 360 - 360

Опубликована: Март 19, 2025

Oxidative stress plays an essential role in neurodegenerative pathophysiology, acting as both a critical signaling mediator and driver of neuronal damage. Hydrogen sulfide (H2S), versatile gasotransmitter, exhibits similarly “Janus-faced” nature, potent antioxidant cytoprotective molecule at physiological concentrations, but becoming detrimental when dysregulated. This review explores the dual roles oxidative H2S normal cellular physiology focusing on disease progression. We highlight potential therapeutic opportunities for targeting redox sulfur-based systems diseases by elucidating intricate balance between these opposing forces.

Язык: Английский

The Janus Face of Oxidative Stress and Hydrogen Sulfide: Insights into Neurodegenerative Disease Pathogenesis DOI Creative Commons
Constantin Munteanu, Anca‐Irina Galaction, Gelu Onose

и другие.

Antioxidants, Год журнала: 2025, Номер 14(3), С. 360 - 360

Опубликована: Март 19, 2025

Oxidative stress plays an essential role in neurodegenerative pathophysiology, acting as both a critical signaling mediator and driver of neuronal damage. Hydrogen sulfide (H2S), versatile gasotransmitter, exhibits similarly “Janus-faced” nature, potent antioxidant cytoprotective molecule at physiological concentrations, but becoming detrimental when dysregulated. This review explores the dual roles oxidative H2S normal cellular physiology focusing on disease progression. We highlight potential therapeutic opportunities for targeting redox sulfur-based systems diseases by elucidating intricate balance between these opposing forces.

Язык: Английский

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