The Effect of Focal Damage to the Right Medial Posterior Cerebellum on Word and Sentence Comprehension and Production

Frontiers in Human Neuroscience, Год журнала: 2021, Номер 15

Опубликована: Май 20, 2021

Functional imaging studies of neurologically intact adults have demonstrated that the right posterior cerebellum is activated during verb generation, semantic processing, sentence and verbal fluency. Studies patients with cerebellar damage converge to show supports processing However, date there are no patient investigated specific importance in language because: (i) case presented lesions affecting anterior (with or without cerebellum), (ii) group combined different regions, specifically reporting effects damage. Here we whether critical for fluency four focal stroke parts (all involving Crus II, lobules VII VIII). We examined detailed lesion location by going beyond common anatomical definitions anatomy (i.e., according vascular territory), employed a recently proposed functional parcellation cerebellum. All experienced difficulties persisted at least month after but three performed normal range within year. In contrast, one more lobule IX than other had profound long-lasting impairments comprehension repetition sentences, production spoken sentences picture description. Spoken written word visual recognition memory were also impaired, however, was range, together object naming, perception short-term memory. This first study leads stroke; most IX. discuss these results relation current theories contribution processing. Overall, our highlights need longitudinal function understand mechanisms support recovery.

Язык: Английский

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Lesion loci of impaired affective prosody: A systematic review of evidence from stroke

Brain and Cognition, Год журнала: 2021, Номер 152, С. 105759 - 105759

Опубликована: Июнь 9, 2021

Язык: Английский

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Multi-model mapping of phonemic fluency

Brain Communications, Год журнала: 2021, Номер 3(4)

Опубликована: Окт. 1, 2021

The voluntary generation of non-overlearned responses is usually assessed with phonemic fluency. Like most frontal tasks, it draws upon different complex processes and systems whose precise nature still incompletely understood. Many claimed aspects regarding the pattern fluency performance its underlying anatomy remain controversial. Major limitations past investigations include small sample size, scant analysis output methodologically insufficient lesion approaches. We investigated a large number patients focal unilateral right or left (n = 110) posterior 100) subcortical 65) lesions imaged magnetic resonance computed tomography compared their on overall responses, words produced over time, extremely infrequent/unknown inappropriate generated. also employed, for first time parcel-based lesion-symptom mapping, tract-wise statistical as well Bayesian multi-variate based meta-analytically defined functional region interest, including interactions. found that damage was associated greater impairment than performance, suggesting shows specificity to lesions. subcorticals, similar frontals, performed significantly worse posteriors regions are involved. However, only effects were words. Parcel-based mapping segment middle superior gyrus, dorsal anterior cingulate gyrus caudate nucleus. Tract-wise revealed disconnections tracts critical. models disconnectome maps implicated inferior dorsomedial regions. Our study suggests set localized areas together several critical word generation. speculate lateralized network exists. It involves medial, supporting process 'energization', which sustains activation duration task concerned 'selection', required due competition by stored words, respectively. methodology adopted represents promising empirically robust approach in furthering our understanding neurocognitive architecture underpinning executive processes.

Язык: Английский

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Toward assessment of human voice biomarkers of brain lesions through explainable deep learning

Biomedical Signal Processing and Control, Год журнала: 2023, Номер 87, С. 105457 - 105457

Опубликована: Сен. 22, 2023

Язык: Английский

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Proceedings of the first global meeting of the Posterior Fossa Society: state of the art in cerebellar mutism syndrome

Child s Nervous System, Год журнала: 2024, Номер 40(7), С. 2177 - 2191

Опубликована: Апрель 22, 2024

Язык: Английский

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