Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
Susceptibility
to
cartilage
degeneration
increases
in
an
age-dependent
manner
and
older
exhibits
increased
catabolic
factor
expression
leading
osteoarthritis
(OA).
While
inhibition
of
cellular
senescence
can
prevent
age-related
diseases,
the
understanding
regulators
governing
potential
for
senolytic
intervention
remains
limited.
Here,
vitro
vivo
results
are
reported,
demonstrating
first
time
that
transcriptional
regulator,
ZMIZ1,
is
upregulated
aged
OA
cartilage,
it
acts
through
GATA4
accelerate
chondrocyte
trigger
deterioration.
Furthermore,
shown
K-7174
interferes
with
ZMIZ1-GATA4
interaction
effectively
hampers
OA.
It
proposed
axis
could
be
a
valuable
strategy
eliminating
senescent
chondrocytes
impeding
development
relevant
inhibitor,
K-7174,
potentially
developed
as
drug
managing
degeneration.
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
This
comprehensive
review
navigates
the
complex
relationship
between
cellular
aging,
senescence,
and
cancer,
unraveling
determinants
of
fate.
Beginning
with
an
overview
aging's
significance
in
explores
processes,
changes,
molecular
pathways
influencing
senescence.
The
senescence
as
a
dual
mechanism
acting
suppressor
contributor,
focusing
on
its
impact
therapy
response.
highlights
opportunities
for
cancer
therapies
that
target
further
examines
senescence-associated
secretory
phenotype
strategies
to
modulate
aging
influence
tumor
behavior.
Additionally,
mechanisms
escape
cells,
emphasizing
their
prognosis
resistance
therapy.
article
addresses
current
advances,
unexplored
aspects,
future
perspectives
understanding
cancer.
Journal of Cosmetic Dermatology,
Год журнала:
2024,
Номер
23(12), С. 4334 - 4342
Опубликована: Авг. 19, 2024
Skin
aging
is
one
of
the
most
abundant
aging-related
disorders
that
can
be
accelerated
by
excessive
exposure
to
ultraviolet
irradiation.
Topically
applied
fermented
skincare
ingredients
have
gained
mounting
attentions
due
their
high
concentration
various
skin
nourishing
nutrients
and
bioactive
components
low
irritation
potency.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
Susceptibility
to
cartilage
degeneration
increases
in
an
age-dependent
manner
and
older
exhibits
increased
catabolic
factor
expression
leading
osteoarthritis
(OA).
While
inhibition
of
cellular
senescence
can
prevent
age-related
diseases,
the
understanding
regulators
governing
potential
for
senolytic
intervention
remains
limited.
Here,
vitro
vivo
results
are
reported,
demonstrating
first
time
that
transcriptional
regulator,
ZMIZ1,
is
upregulated
aged
OA
cartilage,
it
acts
through
GATA4
accelerate
chondrocyte
trigger
deterioration.
Furthermore,
shown
K-7174
interferes
with
ZMIZ1-GATA4
interaction
effectively
hampers
OA.
It
proposed
axis
could
be
a
valuable
strategy
eliminating
senescent
chondrocytes
impeding
development
relevant
inhibitor,
K-7174,
potentially
developed
as
drug
managing
degeneration.
