Advances in Nutrition, Год журнала: 2024, Номер unknown, С. 100304 - 100304
Опубликована: Сен. 1, 2024
Frontiers in Pharmacology, Год журнала: 2025, Номер 15
Опубликована: Янв. 8, 2025
Natural pigments, or natural colorants, are frequently utilized in the food industry due to their diverse functional and nutritional attributes. Beyond color properties, these pigments possess several biological activities, including antioxidant, anti-inflammatory, anticancer, antibacterial, neuroprotective effects, as well benefits for eye health. This review aims provide a timely overview of potential pharmaceutical, medical, industries. Special emphasis is placed on emerging technologies pigment extraction (thermal technologies, non-thermal supercritical fluid extraction), pharmacological application intelligent packaging colorants. show pharmaceutical prospects. For example, delphinidin (30 µM) significantly inhibited growth three cancer cell lines (B16-F10, EO771, RM1) by at least 90% after 48 h. Furthermore, an antioxidant agent, fucoxanthin highest concentration (50 μg/mL) increased ratio glutathione disulfide (p < 0.05). In industry, have been used improve value without altering sensory experience. Moreover, use pH-sensitive freshness indicators cutting-edge technological advancement. innovation could useful information consumers, increase shelf life, assist evaluating quality packaged observing variations over time. However, presents certain challenges, particularly regarding stability higher production costs compared synthetic pigments. situation underscores need further investigation into alternative sources improved stabilization methods. The instability emphasizes tendency degrade change when exposed various external conditions, light, oxygen, temperature fluctuations, pH levels, interactions with other substances matrix.
Язык: Английский
Процитировано
2
Oxford University Press eBooks, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Abstract There is increasing evidence that nutrition has a considerable influence on neurodevelopment. Intake of specific nutrients and bioactives during the necessary developmental period important not only for normal brain development, but also to support cognitive function allow individuals reach their maximum potential. It widely accepted optimal in first 1000 days life key promoting healthy with idea failure neurodevelopment early results consequences may be fully reversible. Comparatively little research focused nutritional childhood adolescence, despite importance these periods. While critical windows create foundation lifelong cognitive, social, emotional behavioral there further opportunity adolescence optimize ameliorate deficits resulting from undernutrition while neuroplasticity still high. In addition nutrition, food provide all we have identified six four are discussed this chapter: protein, folate, iron, iodine, choline, vitamin D, long-chain polyunsaturated fatty acids, gangliosides, human milk oligosaccharides, lutein. Special consideration given understudied interest periods development when applicable.
Язык: Английский
Процитировано
0
Cureus, Год журнала: 2025, Номер unknown
Опубликована: Фев. 22, 2025
Introduction Macular pigment (MP), consisting of lutein (L) and zeaxanthin (Z), is believed to provide retinal protection against photo-oxidative damage. The objective the study was evaluate effect complex 5:1 (extracted from marigold flowers) supplementation on macular optical density (MPOD), contrast sensitivity, quality sleep in healthy subjects who exposed themselves an electronic gadget screen for a minimum 8 hours every day. This also aimed assess long-term safety supplement by administering it months one groups. assessed retention effects MPOD after discontinuation supplementation. Methods registered with Clinical Trial Registry India (CTRI/2022/12/048392). Subjects were screened as per defined inclusion exclusion criteria. aged 18-55 years time at least daily values below 0.8 recruited. study, conducted Narayana Nethralaya Super Specialty Eye Hospital, Bangalore, spanned December 2022 May 2024. randomized, placebo-controlled, crossover study. Of 96 volunteers this 71 recruited, 60 completed divided into 3 groups, viz. A, B, C. Group A received 10mg 2mg twice first four months, had wash-off period 15 days, continued same remaining months. B then switched over placebo next C Placebo 4 All given either, complex-5:1 or capsules randomization chart prepared computationally. analyzed their values, sensitivity scores, sleep. Intraocular pressure, thickness, renal function tests, liver tests during visits ensure clinical safety. Results After lutein-zeaxanthin complex-5:1, average (at 1ᴏ eccentricity) increased significantly. At visit, mean Groups 0.3, 0.22, 0.29 (right eye) 0.31, 0.27, 0.27 (left eye), respectively. second these 0.61, 0.66, 0.21 0.54, 0.53, 0.2 eye). By third 0.7, 0.65, 0.38 0.36 Supplementation significantly improved MPOD, compared placebo. Conclusions resulted higher that intervention led improvement Lutein may be promising remedial measure increasing people prolonged time.
Язык: Английский
Процитировано
0
Advances in Therapy, Год журнала: 2025, Номер unknown
Опубликована: Фев. 27, 2025
Язык: Английский
Процитировано
0
Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 403 - 403
Опубликована: Март 13, 2025
Background: Carotenoids are bioactive tetraterpenoid C40 pigments that actively synthesized by plants, bacteria, and fungi. Compounds such as α-carotene, β-carotene, lycopene, lutein, astaxanthin, β-cryptoxanthin, fucoxanthin, zeaxanthin have attracted increasing attention for their antiaging properties. They exhibit antioxidant, neuroprotective, anti-inflammatory properties, contributing to the prevention treatment of age-related diseases. Objectives: The aim this study was comprehensively analyze pharmacological potential biological mechanisms carotenoids associated with disorders evaluate application in nutraceuticals, pharmaceuticals, cosmeceuticals. Methods: A systematic review studies published over past two decades conducted using databases PubMed, Scopus, Web Science. selection criteria included clinical, silico, vivo, vitro investigating therapeutic effects carotenoids. Results: demonstrate a variety health benefits, including macular degeneration, cancer, cognitive decline, metabolic disorders, skin aging. Their role nutraceuticals is well supported ability modulate oxidative stress inflammatory pathways. In show promising results formulations targeting neurodegenerative diseases disorders. cosmeceuticals, they improve protecting it against UV radiation damage. However, bioavailability, optimal dosages, toxicity, interactions other compounds remain critical factors maximize efficacy still require careful evaluation scientists. Conclusions: interventions applications fields. Further research needed optimize formulas, confirm long-term safety effectiveness, especially aging population.
Язык: Английский
Процитировано
0
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Год журнала: 2025, Номер unknown, С. 159612 - 159612
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Cochrane library, Год журнала: 2025, Номер 2025(4)
Опубликована: Апрель 28, 2025
Язык: Английский
Процитировано
0
Journal of Nutrition, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
2
Life Sciences, Год журнала: 2024, Номер 350, С. 122769 - 122769
Опубликована: Июнь 6, 2024
Язык: Английский
Процитировано
1
Опубликована: Июнь 26, 2024
In the introductory part of this review, relevant results mostly latest experimental studies on carotenoid absorption and availability in human body are briefly presented. The subsequent parts summarise such topics as carriers, transport tissue delivery, before finally reporting molecular-level binding by membrane receptors. main message review is contained section describing computational investigations intercalation dynamic behaviour lipid bilayers. relevance these lies showing direct link between microscopic molecules characteristics their macroscopic ensembles. Furthermore, studying interactions carotenoids bilayers, certainly proteins, molecular- atomic-level using methods facilitates interpretation explanation properties systems and, hopefully, helps to better understand biological functions carotenoids.
Язык: Английский
Процитировано
1