Geographical Variations in Metal Exposure and Its Impact on Metabolic Disorders and Hypertension: An Analysis of Chile's 2016–17 National Health Survey

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Background Evidence suggests that even low-level exposure to metals may disrupt metabolic pathways, contributing disorders. Local environmental factors modulate these effects, emphasizing the importance of territorial disaggregation. This population-based study evaluated geographic variations in four and their associations with obesity, diabetes, syndrome, hypertension Chile. Method Data from 3,822 participants National Health Survey 2016 2017 were analyzed. Biomarkers included inorganic arsenic, cadmium, mercury urine, lead serum. Metal was classified according 50th percentile distribution. Spatial simultaneous autoregressive models accounted for regional disaggregation spatial dependencies, adjusting age, sex, socioeconomic status, smoking. Analyses conducted at national subnational levels, incorporating sampling weights survey complex design. Results A total 42.4% individuals exposed 13.6% lead, 1.7% cadmium. Regional analysis revealed elevated arsenic northern regions (e.g., Arica Antofagasta), peaking 29.9%. At level, adjusted no significant between metal However, geographical linked overweight obesity across most areas diabetes syndrome northern, southernmost, central zones. Mercury associated all conditions macrozone, whereas cadmium exclusively southern regions. Conclusion These findings underscore critical differences metalloid disorders, highlighting need geographically targeted public health interventions consider local contextual factors. Trial registration Not applicable

Язык: Английский

Multi‐omics approach in gut and environmental microbiota research under the One Health concept

EFSA Journal, Год журнала: 2024, Номер 22

Опубликована: Дек. 1, 2024

Abstract The One Health concept, although formulated two decades ago, remains challenging to implement. It necessitates the integration of numerous scientific disciplines, diverse techniques and various professional expertise. Furthermore, it often requires collaboration different institutions, encompassing both administrative entities. This concept posits that human health is intrinsically linked dependent on well‐being animals, plants broader environment, while environment not only sustains life but can also serve as a source xenobiotics affect health‐disease balance. In this context, all components potential exposome, entirety factors natures influence throughout life, must be considered comprehensively. Achieving holistic understanding typically demands application multiple research techniques, known multi‐omics approach adoption an integrated method for data analysis. project endeavoured utilise such approach, examining from origins: (children stool gut microbiota analysis) environmental (groundwater hyporheic zone microbial analysis), well implementing comprehensive informatic tools processing. Analysis samples revealed significant differences in composition across taxonomic levels between normal weight, overweight obese children. Additionally, link certain composition, body weight overall status was identified. groundwater at based sampling location depth. Key geochemical influencing sample diversity were promising results obtained demonstrate viability methodology pave way future initiatives.

Язык: Английский

Penalized Regression Approach for Identifying the Risk Factors of Obesity and Underweight Among Children in North India

Exposure and Health, Год журнала: 2024, Номер unknown

Опубликована: Дек. 25, 2024

Язык: Английский