Diagnostic Markers of Severe COVID‐19 and Community‐Acquired Pneumonia in Children From Southern India
Microbiology and Immunology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
COVID-19
severely
impacts
children
in
India,
with
many
developing
severe
pneumonia
or
multisystem
inflammatory
syndrome
(MIS-C).
Concurrently,
non-COVID-19
respiratory
viruses
causing
community-acquired
(CAP)
have
resurged.
These
conditions
present
similarly,
challenging
accurate
diagnosis.
This
study
aims
to
compare
markers
and
clinical
parameters
pneumonia,
CAP,
COVID-associated
MIS-C.
We
assessed
12
mediators
serum
from
14
16
9
Clinical
characteristics
routine
laboratory
findings
at
admission
were
recorded.
Children
MIS-C
had
significantly
higher
levels
of
IL-1RA,
IL-8,
TNF
compared
those
pneumonia;
CCL2,
HGF,
M-CSF,
IL-8
CAP.
GROα
tended
be
pneumonia.
presentations
similar,
but
patients
distinct
findings,
including
lower
platelet
counts
albumin
levels,
creatinine
liver
enzyme
levels.
exhibited
a
unique
profile.
emerged
as
potential
biomarker
for
MIS-C,
while
increased
merit
further
exploration.
Combining
may
improve
the
diagnosis
differentiation
these
conditions,
enhancing
patient
management.
Язык: Английский
Post-infection gastrointestinal disorders and treatment options
Meditsinskiy sovet = Medical Council,
Год журнала:
2024,
Номер
11, С. 84 - 91
Опубликована: Авг. 6, 2024
The
development
of
post-infectious
pathology
is
determined
by
the
type
pathogen,
genesis
damage
to
intestinal
barrier
and
premorbid
background
child.
On
scale
recent
epidemiological
events,
attention
drawn
SARS-CoV-2
virus,
which
has
tropism
for
cells
gastrointestinal
tract,
distorts
composition
function
microbiome.
importance
functions
microbes
in
outcome
infection
been
highlighted.
It
proven
that
a
microbiota
disorder
with
new
coronavirus
affects
not
only
duration
severity
infectious
process,
but
also
risk
formation
systemic
diseases
malignant
neoplasms.
After
acute
phase
infection,
post-COVID-19
syndrome
may
occur,
pathophysiology
yet
fully
established.
Although
it
believed
main
reason
its
appearance
diversification
microbial
landscape
against
direct
effect
on
ACE2
receptors
epitheliocytes,
followed
pathoimmune
response
impaired
hemostasis.
Established
dysbiosis
underlies
functional
disorders
pronounced
impairment
brain-gut-microbiota
axis
imbalance
migrating
motor
complex,
leading
constipation.
Post-infectious
constipation
debut
within
first
3
months
after
an
infection.
goal
therapy
achieve
regular
painless
defecation
soft-consistency
stool
prevent
feces.
Numerous
foreign
studies
clinical
guidelines
indicate
stimulating
laxatives
are
effective
safe
treatment
constipation,
include
children’s
practice.
Sodium
picosulfate
considered
one
topical
drugs
this
group
laxatives.
Язык: Английский
A retrospective evaluation of SwePEWS use in paediatric patients with COVID‐19 and RSV infection
Acta Paediatrica,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 7, 2024
Abstract
Aim
As
early
detection
of
deterioration
is
a
challenge
in
children,
the
Swedish
Paediatric
Early
Warning
Score
(SwePEWS)
used
to
systematically
assess
paediatric
patients'
clinical
state.
Here,
we
aimed
evaluate
use
and
predictive
ability
SwePEWS.
Methods
Electronic
health
records
patients
admitted
due
respiratory
syncytial
virus
infection
or
COVID‐19
were
reviewed
retrospectively.
Registered
vital
signs
compared
assigned
SwePEWS
score
monitored
sign
values
identify
discrepancies.
Additionally,
SwePEWS's
predict
transfer
intensive
care
unit
(PICU)
was
assessed.
Results
Among
1374
assessments,
one‐third
either
incomplete
contained
errors.
Incomplete
assessments
more
frequent
during
night‐time.
Single
measurements
oxygen
saturation
presented
lower
average
from
continuous
monitoring.
PICU
low.
Conclusion
There
surprisingly
high
occurrence
underestimated
scores.
This
study
provides
new
insights
into
pitfalls
when
developing
implementing
warning
scores
for
systematic
re‐evaluations
patients.
Язык: Английский
Association Between Single-Nucleotide Polymorphisms in Toll-like Receptor 3 (tlr3), tlr7, tlr8 and tirap Genes with Severe Symptoms in Children Presenting COVID-19
Viruses,
Год журнала:
2024,
Номер
17(1), С. 35 - 35
Опубликована: Дек. 30, 2024
The
global
number
of
COVID-19
deaths
has
reached
7
million,
with
4%
these
occurring
in
children
and
adolescents.
In
Brazil,
around
1500
up
to
11
years
old
died
from
the
disease.
most
common
symptoms
are
respiratory,
potentially
progressing
severe
illnesses,
such
as
acute
respiratory
syndrome
(SARS)
MIS-C.
Studies
indicate
that
comorbidities
genetic
factors,
polymorphisms
immune
response
genes,
can
influence
severity
COVID-19.
This
study
investigates
occurrence
single-nucleotide
(SNPs)
innate
genes
Seventy-three
samples
were
analyzed
under
13
hospitalized
at
João
Paulo
II
Children’s
Hospital
due
evaluated
SNPs
tlr8
(1)
(rs3764879),
(2)
(rs2407992),
tlr7
(rs179008),
tlr3
(rs3775291),
tirap
(rs8177374),
mcp-1
(rs1024611),
considering
four
categories
severity:
mild,
moderate,
severe,
critical
To
identify
SNPs,
PCR
sequencing
performed.
frequencies
obtained
not
discrepant
when
compared
described
Global
ALFA,
1000
Genomes,
gnomAD,
American
gnomAD
databases,
except
for
SNP
TLR7.
Comparing
cases
mild
moderate
cases,
we
found
a
higher
relative
risk
associated
mutations
(1),
tlr7,
tlr3,
(p
<
0.05).
No
association
was
mcp-1.
Our
analyses
suggest
an
between
(or
SARS-CoV-2
infected
children).
Язык: Английский