Antioxidants,
Год журнала:
2022,
Номер
11(7), С. 1255 - 1255
Опубликована: Июнь 26, 2022
Nuclear
factor
erythroid
2-related
2
(Nrf2)
signaling
has
become
a
key
pathway
for
cellular
regulation
against
oxidative
stress
and
inflammation,
therefore
an
attractive
therapeutic
target.
Several
organosulfur
compounds
are
reportedly
activators
of
the
Nrf2
pathway.
Organosulfur
constitute
important
class
agents
in
medicinal
chemistry
due
to
their
ability
participate
biosynthesis,
metabolism,
functions,
protection
cells
from
damage.
Sulfur
distinctive
chemical
properties
such
as
large
number
oxidation
states
versatility
reactions
that
promote
fundamental
biological
redox
biochemistry.
The
presence
sulfur
is
responsible
peculiar
features
which
have
been
utilized
stress-mediated
diseases.
activation
being
strategy
closely
tied
sulfur-based
since
react
with
sulfhydryl
(-SH)
groups
common
property
inducers.
Although
some
individual
reported
activators,
there
no
papers
collective
analysis
these
Nrf2-activating
may
help
broaden
knowledge
potentials
motivate
further
research.
In
line
this
fact,
first
time,
review
article
provides
comprehensive
information
on
effects
stress,
thereby
enriching
pharmacological
diversity
activators.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(17)
Опубликована: Янв. 31, 2023
Antimicrobial
resistance
(AMR)
is
one
of
the
biggest
threats
to
environment
and
health.
AMR
rapidly
invalidates
conventional
antibiotics,
antimicrobial
nanomaterials
have
been
increasingly
explored
as
alternatives.
Interestingly,
several
show
AMR-independent
effects
without
detectable
new
therefore
suggested
prevent
evolution.
In
contrast,
some
are
found
trigger
evolution
AMR.
Given
these
seemingly
conflicting
findings,
a
timely
discussion
two
faces
urgently
needed.
This
review
systematically
compares
killing
mechanisms
structure-activity
relationships
antibiotics
nanomaterials.
We
then
focus
on
nano-microbe
interactions
elucidate
impacts
molecular
initiating
events
Finally,
we
provide
an
outlook
future
propose
design
principles
for
prevention
Biomedicines,
Год журнала:
2023,
Номер
11(2), С. 413 - 413
Опубликована: Янв. 31, 2023
The
wide
spread
of
antibiotic
resistance
has
been
alarming
in
recent
years
and
poses
a
serious
global
hazard
to
public
health
as
it
leads
millions
deaths
all
over
the
world.
sharing
genes
between
different
types
bacteria
led
emergence
multidrug
resistant
(MDR)
microorganisms.
This
problem
is
exacerbated
when
microorganisms
create
biofilms,
which
can
boost
bacterial
by
up
1000-fold
increase
MDR
infections.
absence
novel
potent
antimicrobial
compounds
linked
rise
resistance.
sparked
international
efforts
develop
new
improved
agents
well
innovative
efficient
techniques
for
administration
targeting.
There
an
evolution
nanotechnology
treatment
prevention
biofilm
formation
infection.
development
nanomaterial-based
therapeutics,
could
overcome
current
pathways
acquired
drug
resistance,
hopeful
strategy
treating
difficult-to-treat
Additionally,
nanoparticles’
distinct
size
physical
characteristics
enable
them
target
biofilms
treat
pathogens.
review
highlights
advances
combat
In
addition,
provides
insight
on
mechanisms
XDR
infection,
nanoparticles
their
antibacterial
activity.
Moreover,
this
considers
difference
free
antibiotics
nanoantibiotics,
synergistic
effect
nanoantibiotics
planktonic
bacteria,
intracellular
biofilm.
Finally,
we
will
discuss
strength
limitations
application
against
infection
future
perspectives.
Abstract
The
textural
properties
and
surface
chemistry
of
phosphoric
acid-modified
biochars
(PABCs)
prepared
at
different
pyrolysis
temperatures
(500–700
°C)
were
studied
based
on
the
results
obtained
from
XRD,
SEM,
BET,
FT-IR,
Raman,
XPS
elements
analyses.
PABCs
higher
tended
to
possess
a
bigger
proportion
microporous
structure.
adsorption
capacity
initial
rate
for
sulfadiazine
(SDZ)
notably
improved
139.2
mg/g
9.66
mg/(g
min)
as
calculated
Langmuir
model.
equilibrium
time
was
only
one
quarter
that
without
modification.
H
3
PO
4
modification
advantageous
produce
phosphate
break
functional
groups
form
disordered
carbon
structure
abundant
micropores.
enhancement
in
SDZ
due
confinement
effect
hydrophobic
cavities
mircoporous
π–π
electron–donor–acceptor
interaction.
Specially,
exhibited
stable
capacities
wide
pH
range
(3.0–9.0)
or
relatively
high
concentrations
coexisting
ions.
Journal of Coordination Chemistry,
Год журнала:
2023,
Номер
76(5-6), С. 546 - 580
Опубликована: Март 19, 2023
The
discovery
of
new
chemical
entities
having
enhanced
bioactivities
and
improved
functionalities
to
overcome
the
prevailing
antibiotic
resistance
emerging
diseases
has
evolved
as
one
most
needed
research
areas
in
pharmaceutical
field.
Intensive
been
done
on
metal-based
drugs
a
result,
metal
complexes
various
Schiff
bases
are
acknowledged
potential
area
bioinorganic
chemistry
account
their
promising
applicable
uses
several
fields
science.
base
sulfonamides
versatile
pharmacophores
forming
stable
compounds
by
coordinating
with
metals
oxidation
states.
As
therapeutic
candidates,
they
have
actively
used
many
applications
including
antifungal,
analgesic,
anti-inflammatory,
antiviral,
antitumor,
antibacterial
more.
There
worldwide
risk
drug
medical
field
pathogenic
microbes
capable
deactivating
substances.
This
review
summarizes
developments
that
taken
place
from
2008
2022
activities
derived
compounds.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Июль 7, 2023
Abstract
The
sulfonamides
(sulfas)
are
the
oldest
class
of
antibacterial
drugs
and
inhibit
bacterial
dihydropteroate
synthase
(DHPS,
encoded
by
folP
),
through
chemical
mimicry
its
co-substrate
p
-aminobenzoic
acid
(
ABA).
Resistance
to
sulfa
is
mediated
either
mutations
in
or
acquisition
sul
genes,
which
code
for
sulfa-insensitive,
divergent
DHPS
enzymes.
While
molecular
basis
resistance
well
understood,
mechanisms
mediating
-based
have
not
been
investigated
detail.
Here,
we
determine
crystal
structures
most
common
Sul
enzyme
types
(Sul1,
Sul2
Sul3)
multiple
ligand-bound
states,
revealing
a
substantial
reorganization
their
ABA-interaction
region
relative
corresponding
DHPS.
We
use
biochemical
biophysical
assays,
mutational
analysis,
trans
complementation
E.
coli
Δ
show
that
Phe-Gly
sequence
enables
enzymes
discriminate
against
sulfas
while
retaining
ABA
binding
necessary
broad
sulfonamides.
Experimental
evolution
results
strain
harboring
sulfa-resistant
variant
carries
insertion
active
site,
recapitulating
this
mechanism.
also
possess
increased
site
conformational
dynamics
DHPS,
could
contribute
substrate
discrimination.
Our
reveal
foundation
Sul-mediated
drug
facilitate
potential
development
new
less
prone
resistance.
Environmental Science and Pollution Research,
Год журнала:
2024,
Номер
31(9), С. 13185 - 13206
Опубликована: Янв. 19, 2024
Abstract
To
effectively
remove
pharmaceuticals,
nitroaromatic
compounds,
and
dyes
from
wastewater,
an
efficient
multifunctional
material
was
created
based
on
silver
nanoparticles
(Ag)
MIL-125-NH
2
(MOF)
immobilized
viscose
fibers
(VF)
as
a
support
substrate.
Firstly,
were
the
surface
of
via
in
situ
synthesis
using
trisodium
citrate
(TSC)
reducing
agent
to
create
(VF-Ag).
Then,
VF
VF-Ag
decorated
with
titanium
metal–organic
framework
VF-MOF
VF-Ag-MOF.
The
influence
VF-Ag,
VF-MOF,
VF-Ag-MOF
sonocatalytic
or
sonophotocatalytic
degradation
sulfa
drugs
investigated.
results
show
that
showed
excellent
activity
towards
compared
VF-MOF.
Furthermore,
sonophotodegradation
dramatic
enhancement
efficiency
sonodegradation.
percentage
sulfanilamide,
sulfadiazine,
sulfamethazine
presence
65,
90,
95
after
45
min
ultrasonic
visible
light
irradiation.
catalytic
evaluated
through
conversion
p-nitrophenol
(4-NP)
p-aminophenol
(4-AP).
demonstrate
had
highest
activity,
followed
by
4-NP
4-AP
69%.
photocatalytic
effects
elimination
methylene
blue
(MB)
dye
high
removing
MB
reduction
(65%)
photodegradation
(71%)
60
min.
composites
structure–activity
relationships
represent
doping
within
NPs
enhanced
,
which
could
be
explained
follows:
(i)
Due
formation
Schottky
barrier
at
junction
between
Ag
NPs,
photogenerated
electrons
conduction
band
supposed
quickly
transferred
valence
subsequently,
NPs.
This
considerable
electron
transferring
process,
is
reported
Z
scheme
heterojunction,
can
efficiently
suppress
recombination
electron/hole
pairs
VF-Ag-MIL-125-NH
composites.
(ii)
Sufficient
separation
charge
carriers
(holes
electrons)
avoiding
their
Water Research,
Год журнала:
2024,
Номер
254, С. 121416 - 121416
Опубликована: Март 5, 2024
Sulfonamides
are
applied
worldwide
as
antibiotics.
They
emerging
contaminants
of
concern,
their
presence
in
the
environment
may
lead
to
spread
antibiotic
resistance
genes.
present
groundwater
systems,
which
suggest
persistence
under
certain
conditions,
highlighting
importance
understanding
natural
attenuation
processes
groundwater.
Biodegradation
is
an
essential
process,
degradation
sulfonamides
reduces
risk
spreading.
In
this
review,
attenuation,
and
particular
assessment
biodegradation,
evaluated
for
systems.
The
current
knowledge
level
on
biodegradation
reviewed,
a
scientific
foundation
built
based
sulfonamide
processes,
pathways,
metabolites
toxicity.
An
overview
bacterial
species
related
provided.
main
research
effort
has
focused
aerobic
conditions
while
investigations
anaerobic
lacking.
implementation
laboratory
scale;
here
we
strived
bridge
towards
field
application
assessment,
by
assessing
approaches
commonly
used
monitored
attenuation.
Methods
document
contaminant
mass
loss
assessed
be
applicable
sulfonamides,
approach
limited
lack
reference
standards
metabolites.
Furthermore,
additional
information
required
relevant
order
improve
assessments.
Based
it
suggested
use
substituent-containing
from
breakage
specific
indicators
degradation.
Microbial
currently
available
microbial
community's
capacities,
however,
more
indigenous
bacteria
capable
degrading
impact
environmental
biodegradation.
Compound
stable
isotope
analysis
shows
great
potential
situ
method,
but
further
developments
analyse
at
environmentally
levels.
Finally,
scheme
that
can
uncover
some
fate
Nevertheless,
there
still
unknowns
well
effect
settings
such
redox
conditions.
Alongside,
uncovering
future
research,
applicability
documentation
will
advance,
provide
step
remedial
concepts
frequently
detected
sulfonamides.
