Leveraging Immunogenic Cell Death to Enhance the Immune Response against Malignant Pleural Mesothelioma Tumors

Journal of the American Chemical Society, Год журнала: 2025, Номер 147(9), С. 7908 - 7920

Опубликована: Фев. 24, 2025

Although various metal-based compounds have exhibited excellent immunogenic cell death (ICD)-inducing properties both in vitro and vivo, the majority of these been discovered serendipitously. In this work, we successfully synthesized characterized 35 cyclometalated Au(III) complexes containing dithiocarbamate ligands, with 25 being previously unreported. Their ability to induce phagocytosis against immunologically "cold" malignant pleural mesothelioma (MPM) cells was strongly dependent on scaffold overall lipophilicity complexes. We elucidated role mechanisms observed ICD effects identified correlations between necrotic ICD, vivo. Complex 2G, its high rates low necrosis rates, recognized as a bona fide inducer, demonstrating remarkably long-lasting immune response vaccinated mice. contrast, complex 1C, by failed elicit sustained upon following vaccination; however, it triggered selective activation calreticulin tumors direct vivo administration. Overall, study offers framework for predicting structurally similar complexes, potential extension other series metal

Язык: Английский

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Metal-based immunogenic cell death inducers for cancer immunotherapy

Chemical Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Immunogenic cell death (ICD) has attracted enormous attention over the past decade due to its unique characteristics in cancer and role activating innate adaptive immune responses against tumours. Many efforts have been dedicated screening, identifying discovering ICD inducers, resulting validation of several based on metal complexes. In this review, we provide a comprehensive summary current metal-based their molecular mechanisms for triggering initiation subsequent protective antitumour responses, along with considerations validating both vitro vivo. We also aim offer insights into future development complexes enhanced ICD-inducing properties applications potentiating immunity.

Язык: Английский

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Development a stannum(IV) 8-quinolinecarbaldehyde thiosemicarbazone complex with remarkable anticancer activity via pyroptosis and apoptosis

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142225 - 142225

Опубликована: Март 1, 2025

Язык: Английский

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Two New Inner-sphere Pt(II) Thiosemicarbazone Schiff Base Complexes Immobilized into Magnetic Nanoparticles: Synthesis, Characterization, and Biological Investigations

Inorganic Chemistry Communications, Год журнала: 2024, Номер 170, С. 113366 - 113366

Опубликована: Окт. 22, 2024

Язык: Английский

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