Unveiling the causal effects of gut microbiome on trimethylamine N-oxide: evidence from Mendelian randomization DOI Creative Commons
Yunfeng Yu,

Yuman Yin,

Juan Deng

и другие.

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Окт. 25, 2024

The relationship between gut microbiome and trimethylamine oxide (TMAO) has not been fully elucidated. We aimed to assess the causal effects of different microbes on TMAO using Mendelian randomization (MR).

Язык: Английский

Gut microbiota and risk of iron deficiency anemia: A two-sample Mendelian randomization study DOI Creative Commons

Wenhui Lei,

Zhaoyun Liu,

Hai-Ping Lai

и другие.

Medicine, Год журнала: 2025, Номер 104(8), С. e41617 - e41617

Опубликована: Фев. 21, 2025

Previous studies have suggested a link between gut microbiota and iron-deficiency anemia (IDA). However, interpreting these findings is difficult due to various factors that influence microbiome composition the limitations of observational studies, such as confounding variables reverse causation. This study aims explore causal relationship IDA using Mendelian randomization (MR) overcome limitations. We conducted 2-sample MR analysis data from genome-wide association MiBioGen Consortium UK Biobank. The included 211 genus-level microbes linked single-nucleotide polymorphisms 18,340 participants in Consortium. outcome for were obtained 484,598 Biobank, with 2941 cases 481,657 controls. assessed relationships techniques, primarily inverse variance weighting, performed sensitivity analyses confirm robustness our results. Nine significantly associated ( P < .05). Protective Clostridia, Actinomycetaceae, Pasteurellaceae, Oscillospira, Prevotella, Roseburia, while risk Ruminococcus gnavus group, Hungatella, Parasutterella. Sensitivity showed reliability without significant variability. provides evidence specific bacteria risk, identifying potential targets therapies aimed at improving outcomes those IDA. Further research needed clarify involved.

Язык: Английский

Процитировано

0
Sex‐specific associations of Roseburia with uric acid metabolism and hyperuricemia risk in females DOI Creative Commons
Zhihan Yang, Zeng Zhang, Mohan Chen

и другие.

iMetaOmics., Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Abstract Hyperuricemia (HUA) affects approximately 14% of the population, with a marked gender disparity showing lower incidence in females. While role gut microbiota HUA has been extensively studied males, its influence females remains unclear. This study recruited 623 participants, including 270 females, to explore this gap using 16S rDNA sequencing. We found that Roseburia was significantly enriched healthy and negatively correlated estrogen (E2) uric acid (UA) levels. Validation three published cohorts (256 samples) confirmed as critical genus for UA regulation. Mechanistically, positively xanthine‐glycine metabolic pathway, which may production These findings shed light on differences from perspective propose promising target probiotic‐based prevention

Язык: Английский

Процитировано

0
Glucagon-like peptide-1 receptor agonists: Exploring the mechanisms from glycemic control to treatment of multisystemic diseases DOI
Mo-Wei Kong,

Yang Yu,

Ying Wan

и другие.

World Journal of Gastroenterology, Год журнала: 2024, Номер 30(36), С. 4036 - 4043

Опубликована: Сен. 20, 2024

This editorial takes a deeper look at the insights provided by Soresi and Giannitrapani, which examined therapeutic potential of glucagon-like peptide-1 receptor agonists (GLP-1RAs) for metabolic dysfunction-associated fatty liver disease. We provide supplementary to their research, highlighting broader systemic implications GLP-1RAs, synthesizing current understanding mechanisms trajectory research in this field. GLP-1RAs are revolutionizing treatment type 2 diabetes mellitus beyond. Beyond glycemic control, demonstrate cardiovascular renal protective effects, offering managing diabetic kidney disease al-ongside renin–angiotensin–aldosterone system inhibitors. Their role bone metabolism hints benefits osteoporosis, while neuroprotective properties show promise Alzheimer's modulating neuronal insulin signaling. Additionally, they improve hormonal profiles polycystic ovary syndrome. highlights multifaceted emphasizing need ongoing fully realize across range multisystemic diseases.

Язык: Английский

Процитировано

0
Potential therapeutic application and mechanism of gut microbiota-derived extracellular vesicles in polycystic ovary syndrome DOI Open Access

Liangliang Yang,

Tingxiu Liu,

Yan Liao

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 180, С. 117504 - 117504

Опубликована: Сен. 27, 2024

Язык: Английский

Процитировано

0
Gut microbiota in women with polycystic ovary syndrome: an individual based analysis of publicly available data DOI Creative Commons
Yanan Yang,

Jiale Cheng,

Chongyuan Liu

и другие.

EClinicalMedicine, Год журнала: 2024, Номер 77, С. 102884 - 102884

Опубликована: Окт. 18, 2024

Язык: Английский

Процитировано

0
Unveiling the causal effects of gut microbiome on trimethylamine N-oxide: evidence from Mendelian randomization DOI Creative Commons
Yunfeng Yu,

Yuman Yin,

Juan Deng

и другие.

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Окт. 25, 2024

The relationship between gut microbiome and trimethylamine oxide (TMAO) has not been fully elucidated. We aimed to assess the causal effects of different microbes on TMAO using Mendelian randomization (MR).

Язык: Английский

Процитировано

0