Microbiome Markers in Gastrointestinal Disorders: Inflammatory Bowel Disease, Colorectal Cancer, and Celiac Disease DOI Open Access
M. Isabel San-Martín, Alejandro Chamizo‐Ampudia, Africa Sánchiz

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(10), С. 4818 - 4818

Опубликована: Май 17, 2025

Intestinal microbiota and the host’s immune system form a symbiotic alliance that sustains normal development function in human gut. Changes such as dietary habits among societies developed countries have led to of unbalanced microbial populations gut, likely contributing dramatic increase inflammatory diseases last few decades. Recent advances DNA sequencing technologies tremendously helped characterize microbiome associated with disease, both identifying global alterations discovering specific biomarkers potentially contribute disease pathogenesis, evidenced by animal studies. Beyond bacterial alterations, non-bacterial components fungi, viruses, metabolites been implicated these diseases, influencing responses gut homeostasis. Multi-omics approaches integrating metagenomics, metabolomics, transcriptomics offer more comprehensive understanding microbiome’s role paving way for innovative diagnostic therapeutic strategies. Unraveling metagenomic profiles may facilitate earlier diagnosis intervention, well personalized effective This review synthesizes recent relevant research studies aimed at characterizing signatures bowel colorectal cancer, celiac disease.

Язык: Английский

Critical Review of the Cross-Links Between Dietary Components, the Gut Microbiome, and Depression DOI Open Access
Nidesha Randeni, Baojun Xu

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 614 - 614

Опубликована: Янв. 13, 2025

The complex relationship between diet, the gut microbiota, and mental health, particularly depression, has become a focal point of contemporary research. This critical review examines how specific dietary components, such as fiber, proteins, fats, vitamins, minerals, bioactive compounds, shape microbiome influence microbial metabolism in order to regulate depressive outcomes. These dietary-induced changes microbiota can modulate production metabolites, which play vital roles gut–brain communication. axis facilitates this communication through neural, immune, endocrine pathways. Alterations metabolites central nervous system (CNS) functions by impacting neuroplasticity, inflammatory responses, neurotransmitter levels—all are linked onset course depression. highlights recent findings linking components with beneficial composition reduced symptoms. We also explore challenges individual variability responses interventions long-term sustainability these strategies. underscores necessity for further longitudinal mechanistic studies elucidate precise mechanisms diet interactions be leveraged mitigate paving way personalized nutritional therapies.

Язык: Английский

Процитировано

4
Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Biomedicines, Год журнала: 2025, Номер 13(2), С. 422 - 422

Опубликована: Фев. 10, 2025

The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.

Язык: Английский

Процитировано

4
Exploring new Bacteroidota strains: Functional Diversity and Probiotic Characteristics DOI Creative Commons

Lisa Ladewig,

Muhammad Aammar Tufail, Birhanu M. Kinfu

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 4, 2025

Abstract Bacteroidota, a diverse phylum of bacteria, are increasingly recognized for their significant contributions to host health, particularly through antimicrobial and probiotic properties. This study investigates the functional diversity potential 42 new Bacteroidota strains enriched identified from hosts, including mouse ceca human stool samples. Using 16S rRNA gene sequencing, we phylogenetically characterized genera Bacteroides, Phocaeicola Sphingobacterium assessed properties related potential. The were evaluated concerning ability inhibit biofilm formation WHO declared clinically pathogens, gram-positive Staphylococcus aureus epidermidis , gram-negative Klebsiella oxytoca Pseudomonas aeruginosa eukaryotic fungus Candida albicans. Additionally, investigated bile salt hydrolase quorum quenching activities strains, key traits associated with efficacy. Our findings demonstrate that all examined consistently exhibit capacity but different extent. Furthermore, 14 showed activity, 39 highlighting High inhibition as well activity against both autoinducers, AHL AI-2, predominantly observed in Bacteroides caecimuris muris making them attractive candidates next-generation probiotics. Overall, this advances field probiotics by identifying promising therapeutic applications potentially revolutionizing approaches microbiome-based interventions pathogen control clinical settings.

Язык: Английский

Процитировано

1
Next-Generation Probiotics and Chronic Diseases: A Review of Current Research and Future Directions DOI Creative Commons
Ashutosh Tiwari,

Dyah Ika Krisnawati,

Erna Susilowati

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(50), С. 27679 - 27700

Опубликована: Ноя. 26, 2024

The burgeoning field of microbiome research has profoundly reshaped our comprehension human health, particularly highlighting the potential probiotics and fecal microbiota transplantation (FMT) as therapeutic interventions. While benefits traditional are well-recognized, efficacy mechanisms remain ambiguous, FMT's long-term effects still being investigated. Recent advancements in high-throughput sequencing have identified gut microbes with significant health benefits, paving way for next-generation (NGPs). These NGPs, engineered through synthetic biology bioinformatics, designed to address specific disease states enhanced stability viability. This review synthesizes current on NGP stability, challenges delivery, their applications preventing treating chronic diseases such diabetes, obesity, cardiovascular diseases. We explore physiological characteristics, safety profiles, action various strains while also addressing opportunities presented by integration into clinical practice. NGPs revolutionize microbiome-based therapies improve outcomes is immense, underscoring need further optimize ensure safety.

Язык: Английский

Процитировано

8
Temperature-dependent convection induced incremental extraction of anthocyanins from Melastoma dodecandrum Lour. Based on recyclable natural deep eutectic system DOI
Hao Huang, Ping Ying, Ye Wang

и другие.

Food Chemistry, Год журнала: 2025, Номер 484, С. 144331 - 144331

Опубликована: Апрель 13, 2025

Язык: Английский

Процитировано

0
Probiotic Potential and Exopolysaccharide Characterization of Two Native Lactic Acid Bacteria for Functional Applications DOI Creative Commons

Pamela Ascanta,

Anamaria Hanganu, Ioana Cristina Marinaș

и другие.

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106600 - 106600

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Gut Microbiota and Cardiovascular Diseases: Unraveling the Role of Dysbiosis and Microbial Metabolites DOI Open Access
Muttiah Barathan, Alfizah Hanafiah

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 4264 - 4264

Опубликована: Апрель 30, 2025

Cardiovascular diseases (CVDs), including heart failure (HF), hypertension, myocardial infarction (MI), and atherosclerosis, are increasingly linked to gut microbiota dysbiosis its metabolic byproducts. HF, affecting over 64 million individuals globally, is associated with systemic inflammation barrier dysfunction, exacerbating disease progression. Similarly, hypertension MI correlate reduced microbial diversity an abundance of pro-inflammatory bacteria, contributing vascular increased cardiovascular risk. Atherosclerosis also influenced by dysbiosis, key metabolites such as trimethylamine-N-oxide (TMAO) short-chain fatty acids (SCFAs) playing crucial roles in pathogenesis. Emerging evidence highlights the therapeutic potential natural compounds, flavonoids, omega-3 acids, resveratrol, curcumin, marine-derived bioactives, which modulate confer cardioprotective effects. These insights underscore a critical regulator health, suggesting that targeting may offer novel preventive strategies. Further research needed elucidate underlying mechanisms optimize microbiome-based interventions for improved outcomes.

Язык: Английский

Процитировано

0
The Beneficial Use of Artemisia annua, Artemisinin, and Other Compounds in Animal Health DOI Creative Commons

Estefania Morua,

Laura Cuyas, Luis Matías‐Hernández

и другие.

Animals, Год журнала: 2025, Номер 15(10), С. 1359 - 1359

Опубликована: Май 8, 2025

Plants and plant-derived natural products have been used in traditional medicine for centuries. The lack of effective therapies the modern world to address several diseases, increasing development drug resistance, growing interest herbal led study resurgence ancient remedies. A. annua, commonly known as sweet wormwood or annie, is a medicinal plant widely its antimalarial properties. In past decade, evidence has demonstrated plant’s broad therapeutic potential, including antitumoral, antimicrobial, antiparasitic, metabolic, immunomodulatory effects, among others. While most research focused on human health, there exploring veterinary applications annua bioactive compounds, particularly artemisinin. This review aims summarize current knowledge beneficial effects artemisinin, other compounds animal health. It also highlights need standardizing metabolites ensure reliability efficacy treatments explores how artemisinin works synergy with molecules present annua.

Язык: Английский

Процитировано

0
Microbiome and Phageome: Key Factors in Host Organism Function and Disease Prevention in the Context of Microbiome Transplants DOI Creative Commons

Wojciech Jankowski,

Małgorzata Mizielińska, Paweł Nawrotek

и другие.

Applied Sciences, Год журнала: 2025, Номер 15(10), С. 5330 - 5330

Опубликована: Май 10, 2025

The study of interactions between gut microbiota and the well-being host has become increasingly popular in last decades. Growing interest microbiota–host brought attention to faecal transplantation (FMT) as a clinically effective, though still debated, therapeutic approach. This review discusses how limitations characterisation bacteriomes—particularly interindividual variation methodological inconsistencies—may influence outcomes FMT. concept enterotypes is considered framework that could support more refined stratification donors recipients, offering possible route toward greater precision microbiota-based interventions. Further on, touches on subject among host, bacteriome, phageome—the community bacteriophages—with specific focus presence intriguing distribution patterns crAssviruses. final chapters are dedicated discussing current state FMT procedure its variations, well possibility performing virome transplants (FVTs) potentially safer equally efficient alternative.

Язык: Английский

Процитировано

0
Early supplement of probiotics reduces the risk of obesity among preschool children: a real-world observational study DOI Creative Commons
Maolin Zhang, Liwen Ding, Esben Strodl

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Май 15, 2025

Introduction Recent studies have mainly focused on the relationship between probiotic supplementation and childhood obesity in infancy school-age periods, with a lack of research preschool stage (3–7 years). This study aimed to explore whether early probiotics (0–3 years) could reduce risk overweight among preschoolers. Methods A cross-sectional survey was conducted 2022 preschoolers from Longhua District, Shenzhen, China. Their mothers were asked complete structured questionnaire regarding socio-demographic details children during first 0–3 years. Trained professionals measured children’s current weight height. Childhood defined as body mass index (BMI) being at or above cut-offs for age sex according BMI growth curves Chinese children. Multinomial logistic regression analysis aged years controlling potential confounders. Sex differences, gestational birth differences analyzed. Results Among 31,190 included, 1,389 classified obese 4,337 overweight. After confounding factors, multinomial suggested that period associated lower likelihood (AOR = 0.88, 95% CI 0.82 ~ 0.95) 0.82, 0.72 0.93). Children who consumed product containing Bifidobacterium longum subsp . infantis R0033, bifidum R0071, Lactobacillus helveticus R0052 had 0.80 0.96) 0.85, 0.73 0.98). Further stratified analyses showed significant association only girls 0.70, 0.56 0.88), but no observed boys 0.75 1.02). Discussion Probiotic children, gender difference. These findings highlight role preventing obesity.

Язык: Английский

Процитировано

0