Rotenone Induces Parkinsonism with Constipation Symptoms in Mice by Disrupting the Gut Microecosystem, Inhibiting the PI3K-AKT Signaling Pathway and Gastrointestinal Motility
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2079 - 2079
Опубликована: Фев. 27, 2025
Parkinson's
disease
(PD)
is
one
of
the
most
common
neurodegenerative
diseases.
Constipation
a
prodromal
symptom
PD.
It
important
to
investigate
pathogenesis
constipation
symptoms
in
Rotenone
has
been
successfully
used
establish
PD
animal
models.
However,
specific
mechanism
rotenone-induced
not
well
understood.
In
this
work,
we
found
that
appeared
earlier
than
motor
impairment
mice
gavaged
with
low
dose
rotenone
(30
mg/kg·BW).
only
caused
loss
dopaminergic
neurons
and
accumulation
α-synuclein,
but
also
significantly
reduced
serum
5-HT
levels
5-HTR4
striatum
colon.
The
mRNA
expression
aquaporins,
gastrointestinal
motility
factors
(c-Kit,
Cx43,
smMLCK
MLC-3)
mouse
colon
was
regulated
by
rotenone.
addition,
both
brain
showed
inflammation
barrier
dysfunction;
PI3K/AKT
pathway
substantia
nigra
inhibited
Importantly,
structure,
composition
function
gut
microbiota
were
altered
Some
taxa
closely
associated
symptoms,
inflammation,
status
mice.
Akkermansia,
Staphylococcus
Lachnospiraceae_UCG-006
may
play
role
exacerbating
whereas
Acinetobacter,
Lactobacillus,
Bifidobacterium,
Solibacillus
Eubacterium_xylanophilum_groups
be
beneficial
stimulating
peristalsis,
maintaining
alleviating
damage
conclusion,
low-dose
can
cause
parkinsonism
disrupting
intestinal
microecosystem
inhibiting
PI3K-AKT
motility.
Язык: Английский
Peroxisome Proliferator-Activated Receptors (PPARs) May Mediate the Neuroactive Effects of Probiotic Metabolites: An In Silico Approach
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(10), С. 4507 - 4507
Опубликована: Май 9, 2025
It
is
well
established
that
the
gut-brain
axis
(GBA)
a
bidirectional
communication
between
gut
and
brain.
This
axis,
critical
in
maintaining
overall
homeostasis,
regulated
at
neuronal,
endocrine,
immunological
levels,
all
of
which
may
be
influenced
by
microbiota
(GM).
Therefore,
dysbiosis
or
disruption
GM
have
serious
consequences
including
neuroinflammation
due
to
overactivation
immune
system.
Strategies
reestablish
integrity
via
use
probiotics
are
being
pursued
as
novel
therapeutic
intervention
variety
central
peripheral
diseases.
The
mechanisms
leading
efficacy
probiotics,
however,
not
fully
evident.
Here,
we
performed
computational
analysis
on
two
major
namely
Lactobacillus
Lacticaseibacillus
rhamnosus
GG
(formerly
named
rhamnosus,
L.
GG)
Bifidobacterium
animalis
spp.
lactis
(B.
B.
animalis)
only
shed
some
light
their
mechanism(s)
action
but
also
identify
potential
molecular
targets
for
probiotics.
Using
PubMed
web
page
BioCyc
Database
Collection
platform
specifically
analyzed
proteins
affected
metabolites
these
bacteria.
Our
results
indicate
peroxisome
proliferator-activated
receptors
(PPARs),
nuclear
receptor
involved
regulation
inflammation
key
mediators
neuroactive
effect
Язык: Английский
Dietary live microbe intake and its association with Parkinson’s disease in American adults: an NHANES analysis (1999–2018)
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Май 29, 2025
Background
Diet
plays
a
crucial
role
in
sustaining
healthy
body,
and
microbes
have
attracted
significant
scholarly
interest
recent
years
as
an
essential
component
of
diet.
This
study
aims
to
explore
the
association
between
dietary
live
microbe
intake
incidence
Parkinson’s
Disease
(PD)
among
adults
over
40
old.
Methods
A
total
26,033
subjects
NHANES
1999–2018
were
included
this
study,
comprising
314
patients
with
PD,
which
divided
into
three
groups
based
on
their
foods
different
levels
microbial
content:
high,
medium,
low.
The
assessment
subjects’
was
conducted
through
self-reported
questionnaire.
Results
distribution
follows:
34.5%
had
low
intake,
45.4%
medium
20.1%
high
intake.
multivariable
logistic
regression
analysis
revealed
that
(OR
=
0.52,
95%
CI:
0.37–0.74)
0.73,
0.57–0.93)
exhibits
reduced
prevalence
PD
compared
those
Restricted
cubic
spline
(RCS)
indicated
linear
PD.
Furthermore,
stratified
analyses
demonstrate
research
variables
more
pronounced
without
obesity.
Conclusion
demonstrates
inverse
Язык: Английский