Ultrasound-derived muscle assessment system for older adults: a promising muscle mass estimation tool DOI Creative Commons
Xinyi Tang, Songya Huang, Li Huang

и другие.

Age and Ageing, Год журнала: 2022, Номер 51(12)

Опубликована: Ноя. 25, 2022

Abstract Background Quantitative assessment of muscle mass is a critical step in sarcopenia disease management. Expanding upon the use ultrasound foetal growth assessment, we established and validated an ultrasound-derived system for older adults at risk sarcopenia. Methods A total 669 were recruited three cohorts this cross-sectional study. In cohort 1(n = 103), most valuable sites skeletal index (SMI) estimation located among 11 scanning sites. An SMI estimating algorithm based on thickness (MT) was obtained modelling group composed 1 2 (n 309). The reliability equation validity cut-off values verified 3 257), which selected as verification group. Results group, e-SMI low 7.13 kg/m2 men 5.81 women. intraclass correlation between 0.885. sensitivity detecting 93.6% 89.7% women, negative predictive value 94.9% 94.7% Combined with handgrip strength gait speed, had overall diagnostic 92.7% specificity 91.0% Conclusion can be promising tool potential classification tool.

Язык: Английский

Sarcopenia and It's Influencing Factors Among Adults With Asthma, Chronic Obstructive Pulmonary Disease, and Tuberculosis in Penang, Malaysia DOI

Roberta Zani,

Hazwani Ahmad Yusof,

Nurul Ain Azizan

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Abstract Background Chronic respiratory diseases like asthma, chronic obstructive pulmonary disease (COPD), and tuberculosis (TB) are increasing globally, leading to systemic symptoms skeletal muscle dysfunction. Ageing physical inactivity exacerbate sarcopenia, reducing functional capacity, disability, quality of life. However, limited research exists on the prevalence sarcopenia among in low-middle-income countries Malaysia. Hence, this study aims investigate its associated risk factors adults with COPD, TB Penang, Methods A cross-sectional was conducted from June 2023 March 2024. This included 469 patients (mean age: 52.62 ± 16.61 years) diagnosed asthma (n = 180), COPD 186), or 103) receiving treatment chest clinics two governmental hospitals Penang. The SARC-F SARC-CalF questionnaires were used assess participants' sarcopenia. Sarcopenia identified using 2019 criteria Asian Working Group for (AWGS). investigated multivariable logistic regression. Results 18.9% (95% CI 13.5–25.4) 33.9% 27.1–41.2) those TB, 35.9% 26.7–46.0) according AWGS criteria. screening tool showed that 27.3% participants had a positive having independent age, activity body mass index (BMI). For patients, significant Chinese other ethnicities, foreigners, lower daily protein intake, BMI. In moderate activity, BMI history heart failure. Conclusion highlighted burden TB. Non-clinical interventions such as lifestyle modification nutritional support crucial maintain strength delay onset particularly people diseases.

Язык: Английский

Процитировано

0

Sarcopenia and it’s influencing factors among adults with asthma, chronic obstructive pulmonary disease, and tuberculosis in Penang, Malaysia DOI Creative Commons

Roberta Zani,

Hazwani Ahmad Yusof,

Nurul Ain Azizan

и другие.

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 28, 2025

Chronic respiratory diseases like asthma, chronic obstructive pulmonary disease (COPD), and tuberculosis (TB) are increasing globally, leading to systemic symptoms skeletal muscle dysfunction. Ageing physical inactivity exacerbate sarcopenia, reducing functional capacity, disability, quality of life. However, limited research exists on the prevalence sarcopenia among in low-middle-income countries Malaysia. Hence, this study aims investigate its associated risk factors adults with COPD, TB Penang, A cross-sectional was conducted from June 2023 March 2024. This included 469 patients (mean age: 52.62 ± 16.61 years) diagnosed asthma (n = 180), COPD 186), or 103) receiving treatment chest clinics two governmental hospitals Penang. The SARC-F SARC-CalF questionnaires were used assess participants' sarcopenia. Sarcopenia identified using 2019 criteria Asian Working Group for (AWGS). investigated multivariable logistic regression. 18.9% (95% CI 13.5-25.4) 33.9% 27.1-41.2) those TB, 35.9% 26.7-46.0) according AWGS criteria. screening tool showed that 27.3% participants had a positive having independent age, activity body mass index (BMI). For patients, significant Chinese other ethnicities, foreigners, lower daily protein intake, BMI. In moderate activity, BMI history heart failure. highlighted burden TB. Non-clinical interventions such as lifestyle modification nutritional support crucial maintain strength delay onset particularly people diseases.

Язык: Английский

Процитировано

0

Sarcopenia and frailty: An in-depth analysis of the pathophysiology and effect on liver transplant candidates DOI Open Access

Grigorios Christodoulidis,

Kyriaki Tsagkidou,

Dimitra Bartzi

и другие.

World Journal of Hepatology, Год журнала: 2025, Номер 17(5)

Опубликована: Май 27, 2025

Cirrhosis represents the end stage of chronic liver disease, significantly reducing life expectancy as it progresses from a compensated to decompensated state, leading serious complications. Recent improvements in medical treatment have created shift cirrhosis management. Various causes, including hepatitis viruses, alcohol consumption, and fatty contribute are closely linked cancer. The disease develops through hepatocyte necrosis regeneration, resulting fibrosis sinusoidal capillarization, portal hypertension complications such ascites, hepatic encephalopathy, organ dysfunction. also holds an increased risk hepatocellular carcinoma. Diagnosing involves assessing scores blood tests measuring stiffness elastography. Liver transplantation is definitive for end-stage acute failure.

Язык: Английский

Процитировано

0

Dietary Pattern and Dietary Energy from Fat Associated with Sarcopenia in Community-Dwelling Older Chinese People: A Cross-Sectional Study in Three Regions of China DOI Open Access
Cheng Li,

Bingxian Kang,

Ting Zhang

и другие.

Nutrients, Год журнала: 2020, Номер 12(12), С. 3689 - 3689

Опубликована: Ноя. 30, 2020

Associations between dietary patterns (DPs) and sarcopenia remain controversial, fewer studies have mentioned the relationship energy composition sarcopenia. The present cross-sectional study was conducted in three regions of China, to detect associations DPs sarcopenia, identify influencing nutrients. Exploratory factor analysis for DP identification. Logistic regressions were performed explore Dietary nutrients calculated compared among different DPs. Three identified from 861 community-dwelling older people. "mushrooms-fruits-milk" pattern negatively associated with (OR = 0.33, 95% CI 0.14~0.77, p-trend 0.009). Subjects highest quartile showed more abundant intake (1.7 g/kg/d) protein, lower percentage (31%) fat (PEF) than other two Further analyses indicated that PEF (<30%) In conclusion, Chinese This protein low PEF, which may partially contribute its protective effect on Therefore, besides also be considered prevention management

Язык: Английский

Процитировано

19

A Multifactorial Approach for Sarcopenia Assessment: A Literature Review DOI Creative Commons
Rashmi Supriya, Kumar Purnendu Singh, Yang Gao

и другие.

Biology, Год журнала: 2021, Номер 10(12), С. 1354 - 1354

Опубликована: Дек. 20, 2021

Sarcopenia refers to a progressive and generalized weakness of skeletal muscle as individuals age. usually occurs after the age 60 years is associated with persistent decline in strength, function, quality. A comparison risk factors sarcopenia based on European Working Group (1 2) Older People, Asian for 2), International Sarcopenia, Foundation National Institutes Health revealed no consistent patterns. Accordingly, identification single factor unpredictable due its "multifactorial" pathogenesis, involvement multitude factors. Therefore, first aim this review was outline propose that multiple need be considered combination design new experimentation area. secondary highlight biochemical are already identified subjects assist scientists understanding biology pathophysiological mechanisms affecting old people sarcopenia. We also briefly discuss primary outcomes (physical) (social financial) For future investigative purposes, comprehensive may useful considering important utilization panel biomarkers emanating from all pathways involved pathogenesis disease. This help establish uniform consensus screening defining Considering COVID-19 pandemic, impact exacerbated older populations, which requires immediate attention. Here, we suggest strategies advancing development smart technologies deliver exercise era an attempt regress onset These have sarcopenia's outcomes.

Язык: Английский

Процитировано

18

Reference values of skeletal muscle mass, fat mass and fat-to-muscle ratio for rural middle age and older adults in western China DOI

Jiaxing Zhang,

Juan Li, Chen Chen

и другие.

Archives of Gerontology and Geriatrics, Год журнала: 2021, Номер 95, С. 104389 - 104389

Опубликована: Март 7, 2021

Язык: Английский

Процитировано

15

Development and validation of a diagnostic nomogram for sarcopenia in Chinese hemodialysis patients DOI

Danshu Xie,

Qin Zhu, Jianxin Lü

и другие.

Nephrology Dialysis Transplantation, Год журнала: 2022, Номер 38(4), С. 1017 - 1026

Опубликована: Сен. 9, 2022

ABSTRACT Background Sarcopenia is a clinical condition that common in patients with chronic kidney disease (CKD), especially those on dialysis. However, the relatively complicated diagnostic procedure limits its use situations. In this study we aimed to establish simplified tool for diagnosis of sarcopenia hemodialysis (HD). Methods Overall, 757 eligible from seven HD centers Shanghai and Suzhou, China, were recruited 2020 2021. The cross-sectional data analyzed. was diagnosed according Asian Working Group 2019 criteria. Among them, 511 consecutive (77 434 without sarcopenia) five included training set establishment nomogram. Ten investigative parameters including characteristics, body measurements physical performance used derive A total 246 (47 199 validation model. Results average age enrolled 60.4 ± 12.1 years, 59.8% males 90.5% received dialysis using an arteriovenous fistula. rate 16.4%. sets showed no significant differences (15.1% 19.1%, respectively; P = .160). nomogram derived sarcopenia, which based only four features—age, sex, weight grip strength—achieved high C-indexes 0.929 [95% confidence interval (CI) 0.904–0.953] 0.955 (95% CI 0.931–0.979) external sets, respectively, had well-fitted calibration curve. cut-off value 0.725, sensitivity 0.909 specificity 0.816. accurately fewer variables more procedures. Conclusions good capability may be convenient use.

Язык: Английский

Процитировано

11

Associations of parity and cognitive decline, depression, and chronic comorbidity in West China: Results from WCHAT study DOI
Lixing Zhou, Xiaoyan Chen, Gongchang Zhang

и другие.

International Journal of Gynecology & Obstetrics, Год журнала: 2024, Номер 167(3), С. 1010 - 1016

Опубликована: Июль 5, 2024

Язык: Английский

Процитировано

2

Nutrition mediates the relationship between number of teeth and sarcopenia: a pathway analysis DOI Creative Commons
Xin Xia,

Xu Zhigang,

Fengjuan Hu

и другие.

BMC Geriatrics, Год журнала: 2022, Номер 22(1)

Опубликована: Авг. 8, 2022

Abstract Objectives The relationship between the number of teeth and sarcopenia remains poorly investigated. Although nutrition plays an important role in maintaining bone muscle health, complex pathogenesis to be elucidated. Methods A large multi-ethnic sample 4149 participants aged over 50 years old from West China Health Aging Trend (WCHAT) study was analyzed. We examined associations with nutritional status sarcopenia, mediating association sarcopenia. Sarcopenia defined according Asian Working Group for 2019. assessed using Mini Nutrition Assessment-Short Form (MNA-SF) scale. Direct relationships teeth, were multiple linear regression. Mediation models structural equation model (SEM) pathway analysis used test Results Of or older, prevalence 22.5, 9.0% moderate 13.5% severe respectively. Regression indicated a total (β = − 0.327, 95% CI 0.471 0.237, p < 0.001) After adjusted MNA-SF scores, still significant 0.269, 0.364 0.175, 0.001), indicating partial mediation effect nutrition. verified partially mediate (indirect estimate 0.0272, bootstrap 0.0324 0.0222; direct 0.0899, 0.1049 0.0738). And this through impacting SMI 0.0283, 0.0336 0.0232) grip strength 0.0067, 0.0094 0.0043). Structural framework confirmed nutrition, Conclusions Our findings that associated poorer status, supported early assessment intervention oral health mitigate risk

Язык: Английский

Процитировано

10

The “Iron Tale”- iron indices and handgrip strength in community-dwelling adults DOI
Vanda Ho, Chun‐Tsu Lee, Reshma Aziz Merchant

и другие.

Aging Clinical and Experimental Research, Год журнала: 2022, Номер 34(12), С. 3025 - 3032

Опубликована: Сен. 23, 2022

Язык: Английский

Процитировано

10