Abstract
Background
Quantitative
assessment
of
muscle
mass
is
a
critical
step
in
sarcopenia
disease
management.
Expanding
upon
the
use
ultrasound
foetal
growth
assessment,
we
established
and
validated
an
ultrasound-derived
system
for
older
adults
at
risk
sarcopenia.
Methods
A
total
669
were
recruited
three
cohorts
this
cross-sectional
study.
In
cohort
1(n
=
103),
most
valuable
sites
skeletal
index
(SMI)
estimation
located
among
11
scanning
sites.
An
SMI
estimating
algorithm
based
on
thickness
(MT)
was
obtained
modelling
group
composed
1
2
(n
309).
The
reliability
equation
validity
cut-off
values
verified
3
257),
which
selected
as
verification
group.
Results
group,
e-SMI
low
7.13
kg/m2
men
5.81
women.
intraclass
correlation
between
0.885.
sensitivity
detecting
93.6%
89.7%
women,
negative
predictive
value
94.9%
94.7%
Combined
with
handgrip
strength
gait
speed,
had
overall
diagnostic
92.7%
specificity
91.0%
Conclusion
can
be
promising
tool
potential
classification
tool.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Abstract
Background
Chronic
respiratory
diseases
like
asthma,
chronic
obstructive
pulmonary
disease
(COPD),
and
tuberculosis
(TB)
are
increasing
globally,
leading
to
systemic
symptoms
skeletal
muscle
dysfunction.
Ageing
physical
inactivity
exacerbate
sarcopenia,
reducing
functional
capacity,
disability,
quality
of
life.
However,
limited
research
exists
on
the
prevalence
sarcopenia
among
in
low-middle-income
countries
Malaysia.
Hence,
this
study
aims
investigate
its
associated
risk
factors
adults
with
COPD,
TB
Penang,
Methods
A
cross-sectional
was
conducted
from
June
2023
March
2024.
This
included
469
patients
(mean
age:
52.62
±
16.61
years)
diagnosed
asthma
(n
=
180),
COPD
186),
or
103)
receiving
treatment
chest
clinics
two
governmental
hospitals
Penang.
The
SARC-F
SARC-CalF
questionnaires
were
used
assess
participants'
sarcopenia.
Sarcopenia
identified
using
2019
criteria
Asian
Working
Group
for
(AWGS).
investigated
multivariable
logistic
regression.
Results
18.9%
(95%
CI
13.5–25.4)
33.9%
27.1–41.2)
those
TB,
35.9%
26.7–46.0)
according
AWGS
criteria.
screening
tool
showed
that
27.3%
participants
had
a
positive
having
independent
age,
activity
body
mass
index
(BMI).
For
patients,
significant
Chinese
other
ethnicities,
foreigners,
lower
daily
protein
intake,
BMI.
In
moderate
activity,
BMI
history
heart
failure.
Conclusion
highlighted
burden
TB.
Non-clinical
interventions
such
as
lifestyle
modification
nutritional
support
crucial
maintain
strength
delay
onset
particularly
people
diseases.
Chronic
respiratory
diseases
like
asthma,
chronic
obstructive
pulmonary
disease
(COPD),
and
tuberculosis
(TB)
are
increasing
globally,
leading
to
systemic
symptoms
skeletal
muscle
dysfunction.
Ageing
physical
inactivity
exacerbate
sarcopenia,
reducing
functional
capacity,
disability,
quality
of
life.
However,
limited
research
exists
on
the
prevalence
sarcopenia
among
in
low-middle-income
countries
Malaysia.
Hence,
this
study
aims
investigate
its
associated
risk
factors
adults
with
COPD,
TB
Penang,
A
cross-sectional
was
conducted
from
June
2023
March
2024.
This
included
469
patients
(mean
age:
52.62
±
16.61
years)
diagnosed
asthma
(n
=
180),
COPD
186),
or
103)
receiving
treatment
chest
clinics
two
governmental
hospitals
Penang.
The
SARC-F
SARC-CalF
questionnaires
were
used
assess
participants'
sarcopenia.
Sarcopenia
identified
using
2019
criteria
Asian
Working
Group
for
(AWGS).
investigated
multivariable
logistic
regression.
18.9%
(95%
CI
13.5-25.4)
33.9%
27.1-41.2)
those
TB,
35.9%
26.7-46.0)
according
AWGS
criteria.
screening
tool
showed
that
27.3%
participants
had
a
positive
having
independent
age,
activity
body
mass
index
(BMI).
For
patients,
significant
Chinese
other
ethnicities,
foreigners,
lower
daily
protein
intake,
BMI.
In
moderate
activity,
BMI
history
heart
failure.
highlighted
burden
TB.
Non-clinical
interventions
such
as
lifestyle
modification
nutritional
support
crucial
maintain
strength
delay
onset
particularly
people
diseases.
World Journal of Hepatology,
Год журнала:
2025,
Номер
17(5)
Опубликована: Май 27, 2025
Cirrhosis
represents
the
end
stage
of
chronic
liver
disease,
significantly
reducing
life
expectancy
as
it
progresses
from
a
compensated
to
decompensated
state,
leading
serious
complications.
Recent
improvements
in
medical
treatment
have
created
shift
cirrhosis
management.
Various
causes,
including
hepatitis
viruses,
alcohol
consumption,
and
fatty
contribute
are
closely
linked
cancer.
The
disease
develops
through
hepatocyte
necrosis
regeneration,
resulting
fibrosis
sinusoidal
capillarization,
portal
hypertension
complications
such
ascites,
hepatic
encephalopathy,
organ
dysfunction.
also
holds
an
increased
risk
hepatocellular
carcinoma.
Diagnosing
involves
assessing
scores
blood
tests
measuring
stiffness
elastography.
Liver
transplantation
is
definitive
for
end-stage
acute
failure.
Nutrients,
Год журнала:
2020,
Номер
12(12), С. 3689 - 3689
Опубликована: Ноя. 30, 2020
Associations
between
dietary
patterns
(DPs)
and
sarcopenia
remain
controversial,
fewer
studies
have
mentioned
the
relationship
energy
composition
sarcopenia.
The
present
cross-sectional
study
was
conducted
in
three
regions
of
China,
to
detect
associations
DPs
sarcopenia,
identify
influencing
nutrients.
Exploratory
factor
analysis
for
DP
identification.
Logistic
regressions
were
performed
explore
Dietary
nutrients
calculated
compared
among
different
DPs.
Three
identified
from
861
community-dwelling
older
people.
"mushrooms-fruits-milk"
pattern
negatively
associated
with
(OR
=
0.33,
95%
CI
0.14~0.77,
p-trend
0.009).
Subjects
highest
quartile
showed
more
abundant
intake
(1.7
g/kg/d)
protein,
lower
percentage
(31%)
fat
(PEF)
than
other
two
Further
analyses
indicated
that
PEF
(<30%)
In
conclusion,
Chinese
This
protein
low
PEF,
which
may
partially
contribute
its
protective
effect
on
Therefore,
besides
also
be
considered
prevention
management
Biology,
Год журнала:
2021,
Номер
10(12), С. 1354 - 1354
Опубликована: Дек. 20, 2021
Sarcopenia
refers
to
a
progressive
and
generalized
weakness
of
skeletal
muscle
as
individuals
age.
usually
occurs
after
the
age
60
years
is
associated
with
persistent
decline
in
strength,
function,
quality.
A
comparison
risk
factors
sarcopenia
based
on
European
Working
Group
(1
2)
Older
People,
Asian
for
2),
International
Sarcopenia,
Foundation
National
Institutes
Health
revealed
no
consistent
patterns.
Accordingly,
identification
single
factor
unpredictable
due
its
"multifactorial"
pathogenesis,
involvement
multitude
factors.
Therefore,
first
aim
this
review
was
outline
propose
that
multiple
need
be
considered
combination
design
new
experimentation
area.
secondary
highlight
biochemical
are
already
identified
subjects
assist
scientists
understanding
biology
pathophysiological
mechanisms
affecting
old
people
sarcopenia.
We
also
briefly
discuss
primary
outcomes
(physical)
(social
financial)
For
future
investigative
purposes,
comprehensive
may
useful
considering
important
utilization
panel
biomarkers
emanating
from
all
pathways
involved
pathogenesis
disease.
This
help
establish
uniform
consensus
screening
defining
Considering
COVID-19
pandemic,
impact
exacerbated
older
populations,
which
requires
immediate
attention.
Here,
we
suggest
strategies
advancing
development
smart
technologies
deliver
exercise
era
an
attempt
regress
onset
These
have
sarcopenia's
outcomes.
Nephrology Dialysis Transplantation,
Год журнала:
2022,
Номер
38(4), С. 1017 - 1026
Опубликована: Сен. 9, 2022
ABSTRACT
Background
Sarcopenia
is
a
clinical
condition
that
common
in
patients
with
chronic
kidney
disease
(CKD),
especially
those
on
dialysis.
However,
the
relatively
complicated
diagnostic
procedure
limits
its
use
situations.
In
this
study
we
aimed
to
establish
simplified
tool
for
diagnosis
of
sarcopenia
hemodialysis
(HD).
Methods
Overall,
757
eligible
from
seven
HD
centers
Shanghai
and
Suzhou,
China,
were
recruited
2020
2021.
The
cross-sectional
data
analyzed.
was
diagnosed
according
Asian
Working
Group
2019
criteria.
Among
them,
511
consecutive
(77
434
without
sarcopenia)
five
included
training
set
establishment
nomogram.
Ten
investigative
parameters
including
characteristics,
body
measurements
physical
performance
used
derive
A
total
246
(47
199
validation
model.
Results
average
age
enrolled
60.4
±
12.1
years,
59.8%
males
90.5%
received
dialysis
using
an
arteriovenous
fistula.
rate
16.4%.
sets
showed
no
significant
differences
(15.1%
19.1%,
respectively;
P
=
.160).
nomogram
derived
sarcopenia,
which
based
only
four
features—age,
sex,
weight
grip
strength—achieved
high
C-indexes
0.929
[95%
confidence
interval
(CI)
0.904–0.953]
0.955
(95%
CI
0.931–0.979)
external
sets,
respectively,
had
well-fitted
calibration
curve.
cut-off
value
0.725,
sensitivity
0.909
specificity
0.816.
accurately
fewer
variables
more
procedures.
Conclusions
good
capability
may
be
convenient
use.
Abstract
Objectives
The
relationship
between
the
number
of
teeth
and
sarcopenia
remains
poorly
investigated.
Although
nutrition
plays
an
important
role
in
maintaining
bone
muscle
health,
complex
pathogenesis
to
be
elucidated.
Methods
A
large
multi-ethnic
sample
4149
participants
aged
over
50
years
old
from
West
China
Health
Aging
Trend
(WCHAT)
study
was
analyzed.
We
examined
associations
with
nutritional
status
sarcopenia,
mediating
association
sarcopenia.
Sarcopenia
defined
according
Asian
Working
Group
for
2019.
assessed
using
Mini
Nutrition
Assessment-Short
Form
(MNA-SF)
scale.
Direct
relationships
teeth,
were
multiple
linear
regression.
Mediation
models
structural
equation
model
(SEM)
pathway
analysis
used
test
Results
Of
or
older,
prevalence
22.5,
9.0%
moderate
13.5%
severe
respectively.
Regression
indicated
a
total
(β
=
−
0.327,
95%
CI
0.471
0.237,
p
<
0.001)
After
adjusted
MNA-SF
scores,
still
significant
0.269,
0.364
0.175,
0.001),
indicating
partial
mediation
effect
nutrition.
verified
partially
mediate
(indirect
estimate
0.0272,
bootstrap
0.0324
0.0222;
direct
0.0899,
0.1049
0.0738).
And
this
through
impacting
SMI
0.0283,
0.0336
0.0232)
grip
strength
0.0067,
0.0094
0.0043).
Structural
framework
confirmed
nutrition,
Conclusions
Our
findings
that
associated
poorer
status,
supported
early
assessment
intervention
oral
health
mitigate
risk
