A novel Zebrafish model of Alzheimer's disease by Aluminium chloride; involving nitro-oxidative stress, neuroinflammation and cholinergic pathway

European Journal of Pharmacology, Год журнала: 2024, Номер 965, С. 176332 - 176332

Опубликована: Янв. 14, 2024

Язык: Английский

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Multi-target-directed therapeutic strategies for Alzheimer’s disease: controlling amyloid-β aggregation, metal ion homeostasis, and enzyme inhibition

Chemical Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review highlights the potential of multi-target-directed strategies that address amyloid-β aggregation, metal ion dyshomeostasis, and enzyme dysfunction, offering a comprehensive effective approach to treating Alzheimer's disease.

Язык: Английский

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Protective effects of polydatin amphiphilic chitosan nanocarriers against an aluminum chloride-induced model of Alzheimer’s disease in rats: relevance to its anti-inflammatory and antioxidant effects

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Язык: Английский

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Benefits of hesperidin in central nervous system disorders: a review

Anatomy & Cell Biology, Год журнала: 2019, Номер 52(4), С. 369 - 369

Опубликована: Янв. 1, 2019

Citrus species contain significant amounts of flavonoids that possess antioxidant activities; furthermore, dietary citrus is not associated with adverse effects or cytotoxicity in healthy individuals.Hesperidin, which an abundant flavanone glycoside the peel fruits, possesses a variety biological capabilities include and anti-inflammatory actions.Over last few decades, many studies have been investigated actions hesperidin its aglycone, hesperetin, as well their underlying mechanisms.Due to derivatives, cardioprotective anti-cancer these compounds widely reviewed.Although activities neurodegenerative diseases evaluated, potential involvement central nervous system (CNS) disorders, including autoimmune demyelinating disease, requires further investigation terms mechanisms.Thus, present review will focus on role diverse models CNS neuroinflammation, experimental encephalomyelitis, special consideration given disease models.Additionally, current evidence provides information regarding nutraceutical use prevent various disorders.

Язык: Английский

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Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress in the adult rat

Biochemical Pharmacology, Год журнала: 2020, Номер 178, С. 114083 - 114083

Опубликована: Июнь 6, 2020

Язык: Английский

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Attenuation of sodium arsenite-induced cardiotoxicity and neurotoxicity with the antioxidant, anti-inflammatory, and antiapoptotic effects of hesperidin

Environmental Science and Pollution Research, Год журнала: 2020, Номер 28(9), С. 10818 - 10831

Опубликована: Окт. 25, 2020

Язык: Английский

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Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway

Food and Chemical Toxicology, Год журнала: 2021, Номер 157, С. 112591 - 112591

Опубликована: Окт. 4, 2021

Язык: Английский

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The Protective Effects of Melatonin on Aluminum-Induced Hepatotoxicity and Nephrotoxicity in Rats

Oxidative Medicine and Cellular Longevity, Год журнала: 2020, Номер 2020, С. 1 - 12

Опубликована: Окт. 19, 2020

Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity nephrotoxicity following aluminum chloride (AlCl3) treatment rats. Adult male rats were treated AlCl3 (34 mg/kg bwt) eight weeks. Exposure enhanced serum activities liver transaminases (alanine aminotransferase aspartate aminotransferase) increased level bilirubin, addition kidney function markers urea creatinine. intoxication boosted oxidative stress, as evidenced by increases levels lipid peroxidation (LPO) nitric oxide (NO) along simultaneous decreases glutathione (GSH), various antioxidant enzymes, Nrf2 mRNA expression. MEL (5 repressed LPO NO levels, whereas it augmented GSH content. The enzymes GPx, SOD, CAT, GR also restored concomitantly when was administered before AlCl3. suppressed apoptotic effect enhancing Bcl-2 protein expression decreasing proinflammatory cytokines. Histopathological findings tissues confirmed beneficial against toxicity. These indicate that prevents defense system.

Язык: Английский

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Celastrol and thymoquinone alleviate aluminum chloride-induced neurotoxicity: Behavioral psychomotor performance, neurotransmitter level, oxidative-inflammatory markers, and BDNF expression in rat brain

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 151, С. 113072 - 113072

Опубликована: Май 13, 2022

Exposure to aluminum chloride (AlCl3) induces progressive multiregional neurodegeneration in animal models by promoting oxidative stress and neuroinflammation. The current study was designed assess the potential efficacy of natural antioxidants celastrol thymoquinone (TQ) for alleviating AlCl3-induced psychomotor abnormalities oxidative-inflammatory burden male albino rats. Four treatment groups were compared: (i) a vehicle control group, (ii) AlCL3 group receiving daily intraperitoneal (i.p.) injection AlCl3 (10 mg/kg) 6 weeks, (iii) plus TQ mg/kg, i.p.) cotreatment (iv) (1 group. Open-field, rotarod, forced swimming tests conducted locomotor activity, motor coordination, anxiety-like behavior, depressive-like behavior. Acetylcholine (ACh), dopamine, serotonin levels measured brain homogenates. Malondialdehyde (MDA), total antioxidant capacity (TAC), catalase activity as markers, while tumor necrosis factor-α (TNF-α) interlukin-6 (IL-6) expression inflammatory markers. Brain derived neurotrophic factor (BDNF) mRNA an index endogenous neuroprotective response. Daily reduced free ambulation, impaired promoted anxiety- depression-like behaviors, whole-brain ACh, concentrations, increased MDA accumulation, TAC, elevated TNF-α IL-6, suppressed BDNF expression. All these effects significantly reversed or cotreatment. Thus, may be promising treatments neurotoxicity well neurodegenerative diseases involving

Язык: Английский

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Allicin ameliorates aluminium- and copper-induced cognitive dysfunction in Wistar rats: relevance to neuro-inflammation, neurotransmitters and Aβ(1–42) analysis

JBIC Journal of Biological Inorganic Chemistry, Год журнала: 2021, Номер 26(4), С. 495 - 510

Опубликована: Май 22, 2021

Язык: Английский

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